Effect of Coenzyme Q10 Supplementation on Cardiac Function and Quality of Life in Patients with Heart Failure: A Randomized Controlled Trial

Bodea, Olivia; Boia, Eugen Radu; Craciun, Laura Maria; Valcovici, Mihaela Daniela; Motofelea, Alexandru Catalin; Munteanu, Andreea Mara; Streian, Caius Glad; Pop, Gheorghe Nicusor; Dragan, Simona Ruxanda

doi:10.3390/jcm14113675

This is an early access version, the complete PDF, HTML, and XML versions will be available soon.

Open AccessArticle

Effect of Coenzyme Q10 Supplementation on Cardiac Function and Quality of Life in Patients with Heart Failure: A Randomized Controlled Trial

by

Olivia Bodea

^1,2,

Eugen Radu Boia

^3,*,

Laura Maria Craciun

²,

Mihaela Daniela Valcovici

⁴,

Alexandru Catalin Motofelea

⁵

,

Andreea Mara Munteanu

⁶

,

Caius Glad Streian

⁴,

Gheorghe Nicusor Pop

⁷

and

Simona Ruxanda Dragan

²

¹

Department of Doctoral Studies, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania

²

Discipline of Internal Medicine and Ambulatory Care, Prevention and Cardiovascular Recovery, Department VI-Cardiology, “Victor Babes” University of Medicine and Pharmacy, 3000041 Timisoara, Romania

³

Department of Ear, Nose and Throat, Faculty of Medicine, “Victor Babeș” University of Medicine and Pharmacy Timisoara, 2 Eftimie Murgu Sq., 300041 Timisoara, Romania

⁴

Department of Cardiology, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania

⁵

Center for Molecular Research in Nephrology and Vascular Disease, Faculty of Medicine, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania

⁶

Department V, Internal Medicine I—Discipline of Internal Medicine IV, Center of Advanced Research in Cardiology and Hemostasology, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timisoara, Romania

⁷

Center for Modeling Biological Systems and Data Analysis (CMSBAD), “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania

^*

Author to whom correspondence should be addressed.

J. Clin. Med. 2025, 14(11), 3675; https://doi.org/10.3390/jcm14113675

Submission received: 8 April 2025 / Revised: 11 May 2025 / Accepted: 20 May 2025 / Published: 23 May 2025

(This article belongs to the Special Issue Clinical Management of Patients with Heart Failure—2nd Edition)

Download Versions Notes

Abstract

Background/Objectives: Heart failure remains a complex syndrome with high morbidity and mortality, highlighting the urgent need for alternative treatments that address underlying bioenergetic impairments. CoQ10, which plays a crucial role in mitochondrial ATP production, has shown promising results in small studies, although larger trials are needed to confirm its efficacy. Results: This randomized controlled trial investigated the effects of coenzyme Q10 (CoQ10) supplementation on cardiac function and quality of life in heart failure patients. A total of 120 patients were randomly assigned to receive either CoQ10 (2 × 60 mg daily) or a placebo for six months. Baseline characteristics were similar between groups. The primary outcomes were changes in global longitudinal strain (GLS) and left ventricular ejection fractions (LVEFs), while secondary outcomes included improvements in functional capacity and quality of life. At the 6-month endpoint, the CoQ10 group showed significant improvements in GLS (−11.7% to −14.9%, p < 0.001), NT-proBNP levels (815.6 vs. 1378.5 pg/mL, p = 0.012), blood pressure, and 6 min walk test distance (349.3 vs. 267.0 m, p = 0.008) compared to the placebo group. LVEFs improved slightly in the CoQ10 group (38.9% to 40.6%, p = 0.170) but remained unchanged in the placebo group. Conclusions: These findings suggest that CoQ10 supplementation may improve cardiac function, reduce cardiac stress, and enhance functional capacity and quality of life in heart failure patients. Further research is needed to optimize dosage and identify the subgroups that may benefit most from CoQ10 therapy.

Keywords: heart failure; coenzyme Q10 supplementation; MLHFQ; quality of life; global longitudinal strain

Share and Cite

MDPI and ACS Style

Bodea, O.; Boia, E.R.; Craciun, L.M.; Valcovici, M.D.; Motofelea, A.C.; Munteanu, A.M.; Streian, C.G.; Pop, G.N.; Dragan, S.R. Effect of Coenzyme Q10 Supplementation on Cardiac Function and Quality of Life in Patients with Heart Failure: A Randomized Controlled Trial. J. Clin. Med. 2025, 14, 3675. https://doi.org/10.3390/jcm14113675

AMA Style

Bodea O, Boia ER, Craciun LM, Valcovici MD, Motofelea AC, Munteanu AM, Streian CG, Pop GN, Dragan SR. Effect of Coenzyme Q10 Supplementation on Cardiac Function and Quality of Life in Patients with Heart Failure: A Randomized Controlled Trial. Journal of Clinical Medicine. 2025; 14(11):3675. https://doi.org/10.3390/jcm14113675

Chicago/Turabian Style

Bodea, Olivia, Eugen Radu Boia, Laura Maria Craciun, Mihaela Daniela Valcovici, Alexandru Catalin Motofelea, Andreea Mara Munteanu, Caius Glad Streian, Gheorghe Nicusor Pop, and Simona Ruxanda Dragan. 2025. "Effect of Coenzyme Q10 Supplementation on Cardiac Function and Quality of Life in Patients with Heart Failure: A Randomized Controlled Trial" Journal of Clinical Medicine 14, no. 11: 3675. https://doi.org/10.3390/jcm14113675

APA Style

Bodea, O., Boia, E. R., Craciun, L. M., Valcovici, M. D., Motofelea, A. C., Munteanu, A. M., Streian, C. G., Pop, G. N., & Dragan, S. R. (2025). Effect of Coenzyme Q10 Supplementation on Cardiac Function and Quality of Life in Patients with Heart Failure: A Randomized Controlled Trial. Journal of Clinical Medicine, 14(11), 3675. https://doi.org/10.3390/jcm14113675

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Menu

Effect of Coenzyme Q10 Supplementation on Cardiac Function and Quality of Life in Patients with Heart Failure: A Randomized Controlled Trial

Abstract

Share and Cite

Article Metrics

Article Access Statistics

Further Information

Guidelines

MDPI Initiatives

Follow MDPI