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10.3390/jcm13030756
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Review

Endotypes of Paediatric Cough—Do They Exist and Finding New Techniques to Improve Clinical Outcomes

by
Hannah E. O’Farrell
1,2,*,
Hing Cheong Kok
1,3,
Suhani Goel
2,
Anne B. Chang
1,2,4 and
Stephanie T. Yerkovich
1,2
1
NHMRC Centre for Research Excellence in Paediatric Bronchiectasis (AusBREATHE), Child and Maternal Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT 0810, Australia
2
Australian Centre for Health Services Innovation, Queensland University of Technology, Brisbane, QLD 4000, Australia
3
Department of Paediatrics, Sabah Women and Children’s Hospital, Kota Kinabalu 88996, Sabah, Malaysia
4
Department of Respiratory and Sleep Medicine, Queensland Children’s Hospital, Brisbane, QLD 4101, Australia
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2024, 13(3), 756; https://doi.org/10.3390/jcm13030756
Submission received: 20 December 2023 / Revised: 23 January 2024 / Accepted: 23 January 2024 / Published: 28 January 2024
(This article belongs to the Section Respiratory Medicine)
Versions Notes

Abstract

Chronic cough is a common symptom of many childhood lung conditions. Given the phenotypic heterogeneity of chronic cough, better characterization through endotyping is required to provide diagnostic certainty, precision therapies and to identify pathobiological mechanisms. This review summarizes recent endotype discoveries in airway diseases, particularly in relation to children, and describes the multi-omic approaches that are required to define endotypes. Potential biospecimens that may contribute to endotype and biomarker discoveries are also discussed. Identifying endotypes of chronic cough can likely provide personalized medicine and contribute to improved clinical outcomes for children.
Keywords: cough; children; review; endotypes; multi-omics; biomarkers cough; children; review; endotypes; multi-omics; biomarkers

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MDPI and ACS Style

O’Farrell, H.E.; Kok, H.C.; Goel, S.; Chang, A.B.; Yerkovich, S.T. Endotypes of Paediatric Cough—Do They Exist and Finding New Techniques to Improve Clinical Outcomes. J. Clin. Med. 2024, 13, 756. https://doi.org/10.3390/jcm13030756

AMA Style

O’Farrell HE, Kok HC, Goel S, Chang AB, Yerkovich ST. Endotypes of Paediatric Cough—Do They Exist and Finding New Techniques to Improve Clinical Outcomes. Journal of Clinical Medicine. 2024; 13(3):756. https://doi.org/10.3390/jcm13030756

Chicago/Turabian Style

O’Farrell, Hannah E., Hing Cheong Kok, Suhani Goel, Anne B. Chang, and Stephanie T. Yerkovich. 2024. "Endotypes of Paediatric Cough—Do They Exist and Finding New Techniques to Improve Clinical Outcomes" Journal of Clinical Medicine 13, no. 3: 756. https://doi.org/10.3390/jcm13030756

APA Style

O’Farrell, H. E., Kok, H. C., Goel, S., Chang, A. B., & Yerkovich, S. T. (2024). Endotypes of Paediatric Cough—Do They Exist and Finding New Techniques to Improve Clinical Outcomes. Journal of Clinical Medicine, 13(3), 756. https://doi.org/10.3390/jcm13030756

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