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Article

Secukinumab May Be an Effective Treatment Option for Axial Spondyloarthritis and Psoriatic Arthritis Patients with a History of Malignancy: Multicenter Real-Life Experience from Turkey

by
Tuğba Ocak
1,*,
Burcu Yağız
1,
Birol Ocak
2,
Özge Yoğurtçu
3,
Fatma Başıbüyük
4,
Dilek Tezcan
5,
Selime Ermurat
6,
Elif İnanç
7,
Gülşah Yamancan
8,
Fatih Albayrak
9,
Rabia Pişkin Sağır
10,
Ayşe Nur Bayındır Akbaş
11,
Osman Cüre
12,
Belkıs Nihan Coşkun
1,
Servet Yolbaş
7,
Uğur Karasu
11,
Bünyamin Kısacık
13,
Süleyman Serdar Koca
8,
İsmail Sarı
4,
Servet Akar
3,
Ediz Dalkılıç
1 and
Yavuz Pehlivan
1add Show full author list remove Hide full author list
1
Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Uludağ University, 16285 Bursa, Turkey
2
Department of Medical Oncology, Bursa Yüksek İhtisas Training and Research Hospital, 16140 Bursa, Turkey
3
Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, İzmir Katip Çelebi University, 35620 İzmir, Turkey
4
Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Dokuz Eylül University, 35340 İzmir, Turkey
5
Division of Rheumatology, Department of Internal Medicine, Gülhane Faculty of Medicine, University of Health Sciences, 06018 Ankara, Turkey
6
Department of Rheumatology, Bursa Yüksek İhtisas Training and Research Hospital, 16140 Bursa, Turkey
7
Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, İnönü University, 44000 Malatya, Turkey
8
Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Fırat University, 23119 Elazığ, Turkey
9
Department of Rheumatology, Gaziantep City Hospital, 27470 Gaziantep, Turkey
10
Department of Rheumatology, Bitlis Tatvan State Hospital, 13200 Bitlis, Turkey
11
Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Pamukkale University, 20070 Denizli, Turkey
12
Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Recep Tayyip Erdoğan University, 53100 Rize, Turkey
13
Department of Rheumatology, Sanko University Medical Faculty Hospital, 16049 Gaziantep, Turkey
 
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*
Author to whom correspondence should be addressed.
J. Clin. Med. 2024, 13(20), 6216; https://doi.org/10.3390/jcm13206216
Submission received: 13 September 2024 / Revised: 14 October 2024 / Accepted: 16 October 2024 / Published: 18 October 2024
(This article belongs to the Section Dermatology)
Versions Notes

Abstract

:
Background: Secukinumab is a monoclonal antibody against interleukin 17 approved for patients with axial spondyloarthritis (axSpA), psoriatic arthritis (PsA), and psoriasis. Treating axSpA and PsA patients with a history of malignancy is a challenge. While initial results on the applicability of secukinumab in this patient group are positive, the number of studies on this topic remains limited. This study aimed to investigate the drug’s survival time and the efficacy and safety of secukinumab treatment in this specific patient group. Methods: This retrospective study included 30 patients with a history of malignancy who were followed up in rheumatology outpatient clinics in 12 centers throughout Turkey and treated with secukinumab between May 2018 and March 2024 with a diagnosis of axSpA and PsA. Results: The mean follow-up time was 29.8 ± 19.3 months. The drug retention rate was 89.7% after 12 months and 80.6% after 24 months. The most common tumor in our study was papillary thyroid carcinoma (n = 5, 16.7%). During follow-up, local tumor recurrence was observed in a patient with urothelial carcinoma of the bladder. Conclusions: In the largest cohort reported to date, treatment with secukinumab in axSpA and PsA patients with a history of malignancy was not shown to cause oncologic recurrence except for one local tumor recurrence. Drug retention rates were also high, and disease activation and function improved compared to baseline. Therefore, secukinumab could be a safe and effective option for this patient group.

1. Introduction

Axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) are chronic inflammatory diseases within the spondyloarthritis group [1,2]. Nonsteroidal anti-inflammatory drugs and tumor necrosis factor (TNF) inhibitors have been used for many years to treat these diseases in cases of resistance to conventional treatments [3,4]. In recent years, interleukin-17 (IL-17) inhibitors have become an alternative treatment to TNF inhibitors and are also used as first-line biological disease-modifying antirheumatic drugs (bDMARDs). Secukinumab, a fully human immunoglobulin G1 monoclonal antibody targeting IL-17A, has been shown to improve patient symptoms and signs [5]. Our country approved it in May 2018 for treating axSpA and PsA.
When AxSpA and PsA patients have a history of malignancy, treatment management is challenging due to concerns about the impact of biological therapies on cancer recurrence and progression. Although the results are conflicting, TNF and Janus kinase inhibitors should be used with caution in the presence of malignancy as they may affect oncologic prognosis [6,7]. In particular, studies have reported that about half of the patients using biological agents in real life would not meet the inclusion criteria of pivotal randomized controlled trials [8]. A history of malignancy is one of the exclusion criteria in randomized controlled trials. Therefore, the description of the use of biologics such as secukinumab in patients with a history of malignancy is of utmost importance. Although there are few studies on secukinumab, studies have shown that long-term treatment is not associated with an increased risk of cancer development [9,10]. No cancer recurrence was observed in a study conducted with psoriasis patients with malignancy [11]. Similarly, in a study of 22 SpA patients with a history of malignancy, no tumor recurrence was observed [12]. Interestingly, many studies have even found that IL-17A plays an important role in developing various types of cancer [13,14,15]. The inhibition of IL-17 in animal models has shown promising results in preventing tumor progression [16].
AxSpA and PsA patients with a history of malignancy constitute a special population that requires follow-up for both malignant and rheumatologic diseases. Studies on practical experience in this area are limited to a few case series and small patient groups [12,17]. Our multicenter study aimed to investigate the malignancy prognosis, survival, and treatment efficacy of secukinumab in axSpA and PsA patients with a history of cancer.

2. Materials and Methods

2.1. Data Source and Study Design

Twelve rheumatology centers in Turkey participated in this retrospective study. These centers treated 947 outpatients aged 18 and above, diagnosed with axSpA or PsA according to the Assessment of SpondyloArthritis International Society (ASAS) [18] and the Classification Criteria for Psoriatic Arthritis (CASPAR) [19], with secukinumab between May 2018 and March 2024. The status of the primary tumor (T), regional lymph nodes (N), and distant metastases (M) in solid organ malignancies was determined using the TNM classification of the American Joint Committee on Cancer (AJCC) [20]. Lymphoma staging was performed according to the Lugano classification [21]. Patients with AxSpA received 150 mg secukinumab subcutaneously (once a week for four weeks, then every four weeks), and patients with PsA received 300 mg (once a week for four weeks, then every four weeks). The patients’ data were analyzed retrospectively via the hospitals’ electronic system.

2.2. Study Population

Thirty-seven patients were diagnosed with malignancy before secukinumab treatment. Patients were included in this study if they had a history of malignancy, were over 18 years of age, had been treated with secukinumab for axSpA or PsA for at least six months, and had an outpatient follow-up every three months. Seven patients whose duration of treatment with secukinumab had not yet reached six months and who switched to another center for follow-up were excluded from the study. A total of 30 patients were therefore included in the study. Patients who had not received biologic therapy before treatment with secukinumab were defined as bionaive, and patients who had received biologic therapy before treatment with secukinumab were defined as bioexperienced. Both bionaive and bioexperienced patients were included in this study.

2.3. Study Outcomes

Gender, age, body mass index, comorbidities, human leukocyte antigen (HLA) B27 positivity status, number of previous biologic therapies for axSpA and PsA, type of biologic therapies, pathologic information, diagnostic stage, and type of cancer treatment were reviewed. The primary endpoint of this study was tumor recurrence and a new cancer diagnosis during treatment with secukinumab. The primary endpoint was assessed at 3-, 6-, and 12-month visits. The secondary endpoint of this study was the duration of treatment with secukinumab and the efficacy of the treatment. The effectiveness of secukinumab was assessed by erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), 10 cm visual analog scale (VAS) [22], Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) [23], Bath Ankylosing Spondylitis Functional Index (BASFI) [24], and Ankylosing Spondylitis Disease Activity Score (ASDAS) CRP [25] in axSpA and PsA patients with axial involvement. Disease Activity Score-28 (DAS 28) CRP [26] markers were used in PsA patients with only peripheral involvement. The secondary endpoint was assessed at 3-, 6-, and 12-month visits. The survival of secukinumab was quantified as the time from the start of secukinumab until the end of treatment (definitive discontinuation) or until the end of data collection in those patients who continued on treatment. Treatment persistence was defined as information in the retrospectively reviewed outpatient clinic records, showing that the patient was treated with secukinumab at the last outpatient visit and that a secukinumab prescription was issued.

2.4. Statistical Analysis

Statistical analysis was conducted using SPSS (Statistical Package for Social Sciences) version 26.0. Categorical and continuous variables are reported as absolute numbers, percentages, and mean with standard deviation, respectively. The normality of variables was assessed using the Shapiro–Wilk and Kolmogorov–Smirnov tests. The Wilcoxon test was used to compare the change in BASDAI, BASFI, ASDAS CRP, and VAS between the treatment start and the month 12 visit. A paired-samples test was used to compare the change in ESR between the treatment start and the month 12 visit. Kaplan–Meier analysis was used to study the survival of secukinumab.

3. Results

3.1. General Characteristics of Patients

Of the 30 patients included in this study, 20 (66.7%) were male. Their demographic and rheumatologic characteristics are shown in Table 1. The number of patients who were currently smoking and drinking alcohol was four. In 16 patients, comorbidities accompanied the malignancy, and hypertension was the most common comorbidity (n = 8, 26.7%). The age at diagnosis of AxSpA or PsA was 42.4 ± 11.5 years; 20 (66.7%) patients had AxSpA, 8 (26.7%) had PsA with axial involvement, and 2 (6.6%) had PsA with peripheral involvement. Nineteen of the patients were bioexperienced. Ten used two different biologics, eight used one biologic, and one used four different biologics. The most commonly used biologic among experienced patients was adalimumab (n = 12, 63.2%).

3.2. Malignancy Characteristics of Patients

The characteristics of the tumors and the treatments applied are listed in Table 2. The most common tumor was papillary thyroid carcinoma (n = 5, 16.7%), followed by invasive ductal carcinoma of the breast (n = 4, 13.3%), renal cell carcinoma (n = 3, 10%), and prostate adenocarcinoma (n = 3, 10%). Patient 16 had three primary tumors (adenocarcinoma of the colon, renal cell carcinoma, and papillary thyroid carcinoma), and patient 18 had two primary tumors (adenocarcinoma of the lung and basal cell carcinoma). The most common treatment was surgery (n = 28, 93.3%). Twenty-nine patients were in remission when treatment with secukinumab was started. Patient 30, who had differentiated thyroid carcinoma, was being treated with sorafenib for progressive disease at the time of initiation of secukinumab treatment. The median number of months between the diagnosis of malignancy and the start of treatment with secukinumab was 27.5 (2.7–21.8) months. During treatment with secukinumab, no tumor recurrence and no new cancer were observed at 3, 6, and 12 months. During follow-up with secukinumab, a local recurrence was detected in patient 25 after 51.5 months of secukinumab treatment, and the patient underwent reoperation.

3.3. Drug Retention Rates and Effectiveness of Secukinumab Treatment

The mean follow-up time of all patients was 29.8 ± 19.3 months, and the median was 25.3 (7.1–71.3). The drug retention rates of the patients amounted to 89.7% after 12 months and 80.6% after 24 months. The median follow-up time was 26.9 months (9.2–58.4) for bionaive patients and 23.7 months (7.1–71.3) for bioexperienced patients. The secukinumab dose administered was 150 mg for patients with axSpA (n = 20, 66.7%) and 300 mg for patients with PsA (n = 10, 33.3%). Secukinumab treatment was discontinued in five patients due to ineffectiveness; four were bioexperienced. No significant drug-related adverse events were observed in any patients. The duration of secukinumab follow-up for the discontinued patients (patient 6, patient 17, patient 22, patient 23, and patient 28) was 7.1, 11.7, 9.2, 23.7, and 13.2 months, respectively.
When treatment efficacy was assessed after 3 months, ESR was 23.5 (3−70) mm/h, CRP 6.7 (2–30) mg/L, BASDAI 4.2 (1.4–8), BASFI 2.7 (1–7.5), VAS 6 (2–9), and ASDAS CRP 3.3 (1.4–4.17); after 6 months, ESR was 20 (6–56) mm/h, CRP 5.25 (2–23) mg/L, BASDAI 2.7 (1–7.5), BASFI 2.1 (1–24), VAS 4 (1–9), and ASDAS CRP 2.2 ± 0.7; and ESR was 20 ± 9 mm/h, CRP 5 (2–46) mg/L, BASDAI 1.8 (1–6.6), BASFI 1.4 (1–6.9), VAS 2 (0–5), and ASDAS CRP 1.3 (1.1–2.8) at 12 months. The comparison of inflammatory markers and disease activity between the secukinumab baseline and the month 12 visit is shown in Table 3. The ESR, CRP, and VAS values of all patients significantly decreased in the 12th month of secukinumab treatment compared to the baseline visit (p < 0.001, p = 0.001, and p < 0.001, respectively). The ASDAS-CRP scores of patients with axial involvement decreased from 4.3 (range: 3.1–5.2, indicating very high disease activity) to 1.3 (range: 1.1–2.8, indicating remission), and BASDAI scores decreased from 6.2 (range: 5.4–8.2, indicating active disease) to 1.8 (range: 1–6.6, indicating inactive disease). Patients with axial involvement, BASDAI, BASFI, and ASDAS-CRP scores decreased significantly at the month 12 visit following secukinumab treatment compared to the baseline visit (p < 0.001, p < 0.001 and p < 0.001, respectively). There were two PsA patients with peripheral involvement. When evaluating the DAS28-CRP values at baseline and the month 12 visit in these patients, the DAS28-CRP value decreased from 5.2 (indicating very high disease activity) to 2.7 (indicating low disease activity) in one patient and from 5.5 (indicating very high disease activity) to 3.1 (indicating low disease activity) in the other patient.

4. Discussion

This study is the largest real-life experience with axSpA and PsA patients with a history of malignancy. No recurrence was observed during the median follow-up time of 29.8 months, except for local tumor recurrence in one patient. Local tumor recurrence has been observed in early-stage urothelial carcinoma of the bladder. The rate of local tumor recurrence is higher in this early-stage cancer than in many other cancers [27]. Significant improvements in disease activity and functional status were observed, as evidenced by decreased disease activity markers and laboratory parameters. These results suggest that treatment with secukinumab may be a good option for this particular patient group with difficult treatment management.
Studies of patients with a history of malignancy treated with secukinumab have generally been conducted with a small number of patients. The study which had the largest number of patients on this subject was conducted with 44 psoriasis patients. In that study, by Pellegrini et al., no tumor recurrence or new tumor development was observed during treatment with secukinumab, although the mean follow-up time was short [12]. In a study by Tekgöz et al. in SpA patients with a history of malignancy, secukinumab was preferred in seven patients, and no malignant progression was observed during the follow-up period. However, their study was not specific to secukinumab, and the start of treatment with secukinumab and follow-up time were not reported [17]. The study with the highest number of patients related to spondyloarthritis included 22 patients and was conducted recently [12]. Similar to our study, the follow-up time in this study by Farina et al. was more prolonged than in previous studies, with a median of 30 months. Tumor recurrence was not observed, and ASDAS scores improved at the last visit compared to the baseline [12]. In our study, in addition to the study by Farina et al., detailed information on tumor stage at diagnosis was provided, and ASDAS CRP and other activity indices, laboratory parameters, and drug retention rates were evaluated. As two different diseases were treated in this patient group, evaluating tumor progression and rheumatologic disease activity with an oncologic–rheumatologic multidisciplinary approach is important.
The results of our study and previous studies on the use of secukinumab in patients with malignant diseases are favorable. Even in two patients with multiple primary tumors and one patient with active disease before treatment with secukinumab, no tumor progression was observed. In our study, one patient with differentiated thyroid carcinoma with active disease received sorafenib in addition to secukinumab for oncologic treatment. Examples of secukinumab treatment in combination with malignancy treatment can be found in case studies in inflammatory arthritis due to immune checkpoint inhibitors [28]. In two patients with active melanoma who were treated with immune checkpoint inhibitors, inflammatory arthritis developed, and they were treated with secukinumab. In that study, by Vincent et al., no tumor progression developed, and the inflammatory arthritis was controlled with secukinumab [28]. In recent years, the emphasis on the pro-inflammatory and pro-mitogenic role of IL17 has paved the way for the combined use of IL17 inhibitors in inflammatory arthritis [17]. IL-17 activates the tumor microenvironment, characterized by proangiogenic and immunosuppressive properties, and induces inflammatory mediators that can lead to cell growth and metastasis [15]. Consistent with these data, the inhibition of IL 17 has been shown to inhibit tumor progression in animal models [16]. Consistent with all these reassuring results, secukinumab is not thought to confer an increased risk of cancer recurrence.
In our study, survival rates were higher with secukinumab treatment compared with phase III clinical trials and real-world studies [29,30,31,32,33,34,35,36]. In the evaluation of previous studies, bionaive patients showed higher drug retention rates compared to patients with bioexperience [34,35,37,38,39,40]. The reason for the higher drug retention rate in our study compared to previous studies may be the higher proportion of bionaive patients due to a history of malignancy in our inclusion criteria. In addition to high drug retention rates, improvement was found in disease activity indices and inflammation markers at the month 12 visit compared to baseline. Furthermore, secukinumab was well tolerated, and no significant side effects were observed in our study. According to our research and previous studies, secukinumab treatment can be used safely to improve disease activity in patients with axSpA and PsA [34,35,37,38,39,40].
Our study offers valuable insights. Nonetheless, some limitations may impact the generalizability of the results, particularly in assessing cancer recurrence, drug survival, and treatment efficacy. Only descriptive statistics could be provided when evaluating neoplasms due to the heterogeneity of the patients’ cancer types. The small number of patients and the group selected due to the study design may limit the survival and treatment efficacy evaluation. In addition, the retrospective design, including only the Turkish population, and the short follow-up period could affect the generalizability of our results. Despite these limitations, the strengths of our study are that it is multicenter, shows real-life data, has a more extended follow-up period compared to many previous studies, and includes the largest cohort.

5. Conclusions

Our study found no new tumor development and only one instance of local tumor recurrence in urothelial carcinoma of the urinary bladder treated with secukinumab. Survival rates during treatment were high, and there was an observed improvement in disease activation markers compared to baseline at the month 12 visit. Treatment with secukinumab could be an effective and safe option for axSpA and PsA patients with a history of malignancy. Further real-life studies are warranted in this specific patient group, particularly as neoplasms may become more prevalent with the aging population.

Author Contributions

Conceptualization, T.O., B.Y., B.O. and Y.P.; methodology, T.O., B.O. and Y.P.; software, T.O., B.O. and Y.P.; validation, T.O., B.Y., B.O. and Y.P.; formal analysis, T.O. and B.O.; investigation, T.O., B.Y., B.O., B.N.C., E.D. and Y.P.; resources, T.O., B.Y., B.O., B.N.C., E.D. and Y.P.; data curation, T.O., Ö.Y., F.B., D.T., S.E., E.İ., G.Y., F.A., R.P.S., A.N.B.A. and O.C.; writing—original draft preparation, T.O. and B.O.; writing—review and editing, T.O., B.Y., B.O., Ö.Y., F.B., D.T., S.E., E.İ., G.Y., F.A., R.P.S., A.N.B.A., O.C., B.N.C., S.Y., U.K., B.K., S.S.K., İ.S., S.A., E.D. and Y.P.; visualization, T.O., B.Y., B.O., Ö.Y., F.B., E.İ., G.Y., F.A., R.P.S., A.N.B.A., O.C. and U.K.; supervision, T.O., B.Y., B.O., D.T., S.E., F.A., O.C., B.N.C., S.Y., U.K., B.K., S.S.K., İ.S., S.A., E.D. and Y.P.; project administration, T.O. and Y.P. All authors have read and agreed to the published version of the manuscript.

Funding

This research received no external funding.

Institutional Review Board Statement

Our study was conducted in accordance with the 1964 Declaration of Helsinki. The Bursa Uludag University Faculty of Medicine Clinical Research Ethics Committee approved this study (approval no. 2024-7/12, approval date: 8 May 2024).

Informed Consent Statement

The requirement for written informed consent was waived by the Institutional Review Board due to the retrospective nature of this study.

Data Availability Statement

The data presented in this study are available on request from the corresponding author.

Conflicts of Interest

The authors declare no conflicts of interest.

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Table 1. Demographic and rheumatologic features of the study population at the start of secukinumab treatment.
Table 1. Demographic and rheumatologic features of the study population at the start of secukinumab treatment.
Male sex n (%)20 (66.7)
BMI kg/m2 median (minimum–maximum)27.1 (21.4–46.9)
Smoking n (%)
    Current4 (13.3)
    Previous8 (26.7)
    Never18 (60)
Alcohol
    Current4 (13.3)
    Previous1 (3.3)
    Never25 (83.3)
Comorbidity, n (%)
        Hypertension8 (26.7)
        Diabetes mellitus7 (23.3)
        Dyslipidemia5 (16.7)
        Cardiovascular disease2 (6.7)
        Chronic obstructive pulmonary disease1 (3.3)
        Hypothyroidism3 (10)
        Multiple sclerosis1 (3.3)
        Chronic renal failure3 (10)
Spondyloarthritis characteristics
        Diagnosis age of axSpA/PsA years (mean ± std deviation)42.4 ± 11.5
        HLA B27 n (%)17 (56.7)
        AxSpA n (%)20 (66.7)
        PsA with axial involvement n (%)8 (26.7)
        PsA with peripheral involvement n (%)2 (6.6)
        Enthesitis n (%)4 (13.3)
        Dactylitis n (%)3 (10)
        Uveitis n (%)2 (6.7)
        Disease duration, years median (minimum–maximum)12 (1.2–38.1)
Biological therapies
        Bionaive11(36.7)
        Bioexperienced *19(63.3)
                Adalimumab12 (63.2)
                Etanercept7 (36.8)
                Certolizumab4 (21)
                Infliximab4 (21)
                Golilumab4 (21)
                Ustekinumab1 (5.2)
BMI = body mass index, HLA = human leucocyte antigen, AxSpA = axial spondyloarthritis, PsA = psoriatic arthritis. * Some patients received several different biological therapies before treatment with secukinumab.
Table 2. Clinical characteristics of tumors and treatment in our study population.
Table 2. Clinical characteristics of tumors and treatment in our study population.
PatientsSexAge at axSpA/PSA DiagnosisType of CancerAge at Tumor DiagnosisTNM Staging ClassificationType of TherapyTime Between Tumor Diagnosis and Treatment with Secukinumab (Months)Relapse in Cancer During
Secukinumab Treatment		Secukinumab Treatment Duration (Months)
1f30.6Papillary thyroid carcinoma43.5T1N0M0Surgery4.2No50.2
2f32.1Papillary thyroid carcinoma37.8T1N0M0Surgery26.5No14.4
3m40Papillary thyroid carcinoma49T1N0M0Surgery12.2No53
4f65.9Papillary thyroid carcinoma64T1N1M0Surgery
RAI		79.8No58.4
5f37Papillary thyroid carcinoma44.1T1N1M0Surgery11.3No16.5
6f34.6Breast invasive ductal carcinoma45.9T1N1M0Surgery
Chemotherapy
Radiotherapy
Hormonotherapy		59.7No7.1
7m63Breast invasive ductal carcinoma71T1N0M0Surgery
Radiotherapy
Hormonotherapy		118.1No32.3
8f25.1Breast invasive ductal carcinoma49.1T1N0M0Surgery
Radiotherapy
Hormonotherapy		171.7No15.3
9f45.4Breast invasive ductal carcinoma47.4T1N0M0Surgery
Radiotherapy
Hormonotherapy		111.4No26.9
10m20.9Renal cell carcinoma40.1T1N0M0Surgery3.4No11.3
11m39.3Renal cell carcinoma52T1N0M0Surgery2.7No17.5
12m49.8Renal cell carcinoma56.9T1N0M0Surgery14.4No37.7
13m54.3Prostate adenocarcinoma66.3T2N0M0Surgery98.6No15.3
14m49.4Prostate adenocarcinoma62.5T2N0M0Surgery5No71.3
15m65.8Prostate adenocarcinoma68.6T1N0M0Surgery28.6No51.4
16m47.8Colon adenocarcinoma54.4T4N0M0Surgery
Chemotherapy
Radiotherapy		95.4No10.6
Renal cell carcinoma54.4T1N0M0Surgery95.4No
Papillary thyroid carcinoma55.1T1N0M0Surgery86.9No
17m37.2Colon adenocarcinoma32.2T3N1M0Surgery
Chemotherapy		218No11.7
18m56.6Lung adenocarcinoma66.6T1N0M0Surgery18.5No46.6
Basal-cell carcinoma60.6T1N0M0Surgery90.5No
19m54Lung adenocarcinoma66T1N0M0Surgery59.2No18.1
20m51.1Lung squamous-cell carcinoma65.1T2N2M0Surgery
Chemotherapy
Radiotherapy		28.6No12.3
21m45.9Rectum adenocarcinoma48.9T1N0M0Surgery12.2No40.8
22f39.9Uterine endometrioid carcinoma45.9T1N0M0Surgery
Brachytherapy		136.7No9.2
23f39.8Cervix squamous-cell carcinoma39.4T1N0M0Surgery105.7No23.7
24f37.2Mucinous ovarian carcinoma46.7T1N0M0Surgery15.4No67
25m52Bladder urothelial carcinoma53.9T1N0M0Surgery17.6Yes61.4
26m50.3Jejunoileal gastrointestinal stromal tumors53.3T2N0M0Surgery25.4No15.5
27m33Liposarcoma41.2T2N0M0Surgery
Radiotherapy		58.5No29
28f28.9Diffuse large B-cell lymphoma38.3Stage 2Chemotherapy10.4No13.2
29f32.8Diffuse large B-cell lymphoma29.2Stage 2Chemotherapy58.6No26.9
30m34.8Differentiated thyroid carcinoma47.1T3N1M0Surgery
RAI
Sorafenib after recurrence		21.6No28.3
T = tumor, N = node, M = metastasis, m = male, f = female, RAI = radioactive iodine.
Table 3. Comparison of inflammatory markers and disease activity between secukinumab baseline and 12th-month visit.
Table 3. Comparison of inflammatory markers and disease activity between secukinumab baseline and 12th-month visit.
Baseline Visit12th-Month Visitp-Value
ESR (mm/h)39.3 ± 2020 ± 9<0.001 a
CRP (mg/L)20.6 (2–73)5 (2–46)0.001 b
BASDAI6.2 (5.4–8.2)1.8 (1–6.6)<0.001 b
BASFI5.5 (3.2–8.1)1.4 (1–6.9)<0.001 b
VAS (0–10)8 (6–10)2 (0–5)<0.001 b
ASDAS CRP4.3 (3.1–5.2)1.3 (1.1–2.8)<0.001 b
ESR = erythrocyte sedimentation rate, CRP = C-reactive protein, BASDAI = Bath Ankylosing Spondylitis Disease Activity Index, BASFI = Bath Ankylosing Spondylitis Functional Index, VAS = visual analog scale, ASDAS = Ankylosing Spondylitis Disease Activity Score. a Paired-samples test; b Wilcoxon test.
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Ocak, T.; Yağız, B.; Ocak, B.; Yoğurtçu, Ö.; Başıbüyük, F.; Tezcan, D.; Ermurat, S.; İnanç, E.; Yamancan, G.; Albayrak, F.; et al. Secukinumab May Be an Effective Treatment Option for Axial Spondyloarthritis and Psoriatic Arthritis Patients with a History of Malignancy: Multicenter Real-Life Experience from Turkey. J. Clin. Med. 2024, 13, 6216. https://doi.org/10.3390/jcm13206216

AMA Style

Ocak T, Yağız B, Ocak B, Yoğurtçu Ö, Başıbüyük F, Tezcan D, Ermurat S, İnanç E, Yamancan G, Albayrak F, et al. Secukinumab May Be an Effective Treatment Option for Axial Spondyloarthritis and Psoriatic Arthritis Patients with a History of Malignancy: Multicenter Real-Life Experience from Turkey. Journal of Clinical Medicine. 2024; 13(20):6216. https://doi.org/10.3390/jcm13206216

Chicago/Turabian Style

Ocak, Tuğba, Burcu Yağız, Birol Ocak, Özge Yoğurtçu, Fatma Başıbüyük, Dilek Tezcan, Selime Ermurat, Elif İnanç, Gülşah Yamancan, Fatih Albayrak, and et al. 2024. "Secukinumab May Be an Effective Treatment Option for Axial Spondyloarthritis and Psoriatic Arthritis Patients with a History of Malignancy: Multicenter Real-Life Experience from Turkey" Journal of Clinical Medicine 13, no. 20: 6216. https://doi.org/10.3390/jcm13206216

APA Style

Ocak, T., Yağız, B., Ocak, B., Yoğurtçu, Ö., Başıbüyük, F., Tezcan, D., Ermurat, S., İnanç, E., Yamancan, G., Albayrak, F., Sağır, R. P., Bayındır Akbaş, A. N., Cüre, O., Coşkun, B. N., Yolbaş, S., Karasu, U., Kısacık, B., Koca, S. S., Sarı, İ., ... Pehlivan, Y. (2024). Secukinumab May Be an Effective Treatment Option for Axial Spondyloarthritis and Psoriatic Arthritis Patients with a History of Malignancy: Multicenter Real-Life Experience from Turkey. Journal of Clinical Medicine, 13(20), 6216. https://doi.org/10.3390/jcm13206216

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