Longitudinal Analysis of Diabetes Mellitus Risk: Smoking Status and Smoking Cessation
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Population
2.2. Data Collection
2.3. Statistical Analysis
3. Results
4. Discussion
4.1. Study Strengths and Limitations
4.2. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
- Choi, J.W.; Han, E.; Kim, T.H. Association of smoking cessation after new-onset type 2 diabetes with overall and cause-specific mortality among Korean men: A nationwide population-based cohort study. BMJ Open Diabetes Res. Care 2020, 8, e001249. [Google Scholar] [CrossRef] [PubMed]
- Yu, B.; Sun, Y.; Yu, Y.; Yu, Y.; Wang, Y.; Wang, B.; Tan, X.; Wang, Y.; Lu, Y.; Wang, N. Cardiovascular health, sleeping duration, and risk of mortality in current and former smokers. Nutr. Metab. Cardiovasc. Dis. 2024, 34, 1257–1266. [Google Scholar] [CrossRef] [PubMed]
- Kim, S.H.; Park, M.; Kim, G.R.; Joo, H.J.; Jang, S.I. Association of Mixed Use of Electronic and Conventional Cigarettes and Exposure to Secondhand Smoke with Prediabetes. J. Clin. Endocrinol. Metab. 2022, 107, e44–e56. [Google Scholar] [CrossRef] [PubMed]
- Willi, C.; Bodenmann, P.; Ghali, W.A.; Faris, P.D.; Cornuz, J. Active smoking and the risk of type 2 diabetes: A systematic review and meta-analysis. JAMA 2007, 298, 2654–2664. [Google Scholar] [CrossRef]
- Lycett, D.; Nichols, L.; Ryan, R.; Farley, A.; Roalfe, A.; Mohammed, M.A.; Szatkowski, L.; Coleman, T.; Morris, R.; Farmer, A.; et al. The association between smoking cessation and glycaemic control in patients with type 2 diabetes: A THIN database cohort study. Lancet Diabetes Endocrinol. 2015, 3, 423–430. [Google Scholar] [CrossRef] [PubMed]
- Akter, S.; Okazaki, H.; Kuwahara, K.; Miyamoto, T.; Murakami, T.; Shimizu, C.; Shimizu, M.; Tomita, K.; Nagahama, S.; Eguchi, M.; et al. Smoking, Smoking Cessation, and the Risk of Type 2 Diabetes among Japanese Adults: Japan Epidemiology Collaboration on Occupational Health Study. PLoS ONE 2015, 10, e0132166. [Google Scholar] [CrossRef]
- Yeh, H.C.; Duncan, B.B.; Schmidt, M.I.; Wang, N.Y.; Brancati, F.L. Smoking, smoking cessation, and risk for type 2 diabetes mellitus: A cohort study. Ann. Intern. Med. 2010, 152, 10–17. [Google Scholar] [CrossRef] [PubMed]
- Hu, Y.; Zong, G.; Liu, G.; Wang, M.; Rosner, B.; Pan, A.; Willett, W.C.; Manson, J.E.; Hu, F.B.; Sun, Q. Smoking Cessation, Weight Change, Type 2 Diabetes, and Mortality. N. Engl. J. Med. 2018, 379, 623–632. [Google Scholar] [CrossRef]
- Wu, L.; Wang, X.; Dong, J.Y.; Zhao, Y.T.; Lou, H. Smoking Cessation, Weight Gain, and Risk for Type 2 Diabetes: A Prospective Study. Int. J. Public Health 2022, 67, 1604654. [Google Scholar] [CrossRef]
- Luo, J.; Rossouw, J.; Tong, E.; Giovino, G.A.; Lee, C.C.; Chen, C.; Ockene, J.K.; Qi, L.; Margolis, K.L.O. Smoking and diabetes: Does the increased risk ever go away? Am. J. Epidemiol. 2013, 178, 937–945. [Google Scholar] [CrossRef]
- Yoo, T.K.; Oh, B.K.; Lee, M.Y.; Sung, K.C. Association between physical activity and insulin resistance using the homeostatic model assessment for insulin resistance independent of waist circumference. Sci. Rep. 2022, 12, 6002. [Google Scholar] [CrossRef] [PubMed]
- Choi, J.H.; Lee, K.A.; Moon, J.H.; Chon, S.; Kim, D.J.; Kim, H.J.; Kim, N.H.; Seo, J.A.; Kim, M.K.; Lim, J.H.; et al. 2023 Clinical Practice Guidelines for Diabetes Mellitus of the Korean Diabetes Association. Diabetes Metab. J. 2023, 47, 575–594. [Google Scholar] [CrossRef] [PubMed]
- Blauw, L.L.; Boon, M.R.; Rosendaal, F.R.; de Mutsert, R.; Gast, K.B.; van Dijk, K.W.; Rensen, P.C.; Dekkers, O.M. Smoking is associated with increased resting energy expenditure in the general population: The NEO study. Metabolism 2015, 64, 1548–1555. [Google Scholar] [CrossRef] [PubMed]
- Nicklas, B.J.; Tomoyasu, N.; Muir, J.; Goldberg, A.P. Effects of cigarette smoking and its cessation on body weight and plasma leptin levels. Metabolism 1999, 48, 804–808. [Google Scholar] [CrossRef]
- Campagna, D.; Alamo, A.; Di Pino, A.; Russo, C.; Calogero, A.E.; Purrello, F.; Polosa, R. Smoking and diabetes: Dangerous liaisons and confusing relationships. Diabetol. Metab. Syndr. 2019, 11, 85. [Google Scholar] [CrossRef]
- Agarwal, R. Smoking, oxidative stress and inflammation: Impact on resting energy expenditure in diabetic nephropathy. BMC Nephrol. 2005, 6, 13. [Google Scholar] [CrossRef] [PubMed]
- Bergman, B.C.; Perreault, L.; Hunerdosse, D.; Kerege, A.; Playdon, M.; Samek, A.M.; Eckel, R.H. Novel and reversible mechanisms of smoking-induced insulin resistance in humans. Diabetes 2012, 61, 3156–3166. [Google Scholar] [CrossRef] [PubMed]
- Bakhru, A.; Erlinger, T.P. Smoking cessation and cardiovascular disease risk factors: Results from the Third National Health and Nutrition Examination Survey. PLoS Med. 2005, 2, e160. [Google Scholar] [CrossRef] [PubMed]
- Gonseth, S.; Locatelli, I.; Bize, R.; Nusslé, S.; Clair, C.; Pralong, F.; Cornuz, J. Leptin and smoking cessation: Secondary analyses of a randomized controlled trial assessing physical activity as an aid for smoking cessation. BMC Public Health 2014, 14, 911. [Google Scholar] [CrossRef]
- Kryfti, M.; Dimakou, K.; Toumbis, M.; Daniil, Z.; Hatzoglou, C.; Gourgoulianis, K.I. Effects of smoking cessation on serum leptin and adiponectin levels. Tob. Induc. Dis. 2015, 13, 30. [Google Scholar] [CrossRef]
- Jang, J.H.; Kim, W.; Moon, J.S.; Roh, E.; Kang, J.G.; Lee, S.J.; Ihm, S.H.; Huh, J.H. Association between Sleep Duration and Incident Diabetes Mellitus in Healthy Subjects: A 14-Year Longitudinal Cohort Study. J. Clin. Med. 2023, 12, 2899. [Google Scholar] [CrossRef] [PubMed]
- Lee, S.B.; Jo, M.K.; Moon, J.E.; Lee, H.J.; Kim, J.K. Relationship between Handgrip Strength and Incident Diabetes in Korean Adults According to Gender: A Population-Based Prospective Cohort Study. J. Clin. Med. 2024, 13, 627. [Google Scholar] [CrossRef] [PubMed]
- Sung, K.C. Arterial Stiffness and Incident Diabetes. Pulse 2024, 12, 12–18. [Google Scholar] [CrossRef] [PubMed]
- Bajaj, M. 21. Nicotine and insulin resistance: When the smoke clears. Diabetes 2012, 61, 3078–3080. [Google Scholar] [CrossRef] [PubMed]
- Driva, S.; Korkontzelou, A.; Tonstad, S.; Tentolouris, N.; Katsaounou, P. The Effect of Smoking Cessation on Body Weight and Other Metabolic Parameters with Focus on People with Type 2 Diabetes Mellitus. Int. J. Environ. Res. Public Health 2022, 19, 13222. [Google Scholar] [CrossRef]
- Stadler, M.; Tomann, L.; Storka, A.; Wolzt, M.; Peric, S.; Bieglmayer, C.; Pacini, G.; Dickson, S.L.; Brath, H.; Bech, P.; et al. Effects of smoking cessation on β-cell function, insulin sensitivity, body weight, and appetite. Eur. J. Endocrinol. 2014, 170, 219–227. [Google Scholar] [CrossRef]
- Oba, S.; Noda, M.; Waki, K.; Nanri, A.; Kato, M.; Takahashi, Y.; Poudel-Tandukar, K.; Matsushita, Y.; Inoue, M.; Mizoue, T.; et al. Smoking cessation increases short-term risk of type 2 diabetes irrespective of weight gain: The Japan Public Health Center-Based Prospective Study. PLoS ONE 2012, 7, e17061. [Google Scholar] [CrossRef]
Total | Non-DM | DM | p-Value | |
---|---|---|---|---|
Number | 386,558 (100.0%) | 367,508 (95.1%) | 19,050 (4.9%) | |
Age, years | 36.81 ± 8.12 | 36.67 ± 8.05 | 39.48 ± 8.94 | <0.001 |
Male, n (%) | 208,733 (54.0%) | 194,243 (52.9%) | 14,490 (76.1%) | <0.001 |
BMI, kg/m2 | 23.18 ± 3.28 | 23.05 ± 3.21 | 25.68 ± 3.53 | <0.001 |
Higher education, n (%) | 242,607 (62.8%) | 231,921 (63.1%) | 10,686 (56.1%) | <0.001 |
Regular exercise, n (%) | 54,109 (14.0%) | 51,163 (13.9%) | 2946 (15.5%) | <0.001 |
Alcohol intake, g/day | 5.00 (1.00–14.00) | 5.00 (1.00–14.00) | 8.00 (2.00–20.00) | <0.001 |
High alcohol intake, n (%) | 42,901 (11.1%) | 39,965 (10.9%) | 2936 (15.4%) | <0.001 |
Fasting glucose, mg/dL | 92.00 (87.00–98.00) | 92.00 (87.00–97.00) | 102.00 (94.00–110.00) | <0.001 |
Total cholesterol, mg/dL | 190.74 ± 33.28 | 190.11 ± 33.03 | 202.87 ± 35.56 | <0.001 |
LDL-C, mg/dL | 114.61 ± 30.82 | 114.12 ± 30.67 | 124.12 ± 32.04 | <0.001 |
HDL-C, mg/dL | 57.86 ± 14.69 | 58.24 ± 14.72 | 50.51 ± 11.91 | <0.001 |
Triglycerides, mg/dL | 91.00 (64.00–134.00) | 89.00 (64.00–131.00) | 139.00 (95.00–201.00) | <0.001 |
HbA1C | 5.45 ± 0.29 | 5.44 ± 0.28 | 5.71 ± 0.36 | <0.001 |
SBP, mmHg | 110.42 ± 13.28 | 110.03 ± 13.11 | 118.06 ± 14.17 | <0.001 |
DBP, mmHg | 71.00 ± 9.79 | 70.71 ± 9.68 | 76.66 ± 10.22 | <0.001 |
HTN | 39,151 (10.1%) | 34,484 (9.4%) | 4667 (24.5%) | <0.001 |
Smoking status | <0.001 | |||
Never smoker | 237,151 (61.3%) | 229,993 (62.6%) | 7158 (37.6%) | |
Former smoker | 68,443 (17.7%) | 63,324 (17.2%) | 5119 (26.9%) | |
Current smoker | 80,964 (20.9%) | 74,191 (20.2%) | 6773 (35.6%) |
Number | Event * | HR (Model 1) | HR (Model 2) | HR (Model 3) | HR (Model 4) | |
---|---|---|---|---|---|---|
Smoking status | ||||||
Never smoker | 237,151 | 7158 | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) |
Former smoker | 68,443 | 5119 | 1.1 (1.06–1.15) | 1.07 (1.03–1.12) | 1.04 (0.999–1.09) | 1.04 (0.999–1.08) |
Current smoker | 80,964 | 6773 | 1.39 (1.34–1.45) | 1.29 (1.24–1.34) | 1.29 (1.24–1.35) | 1.29 (1.24–1.35) |
Smoking status | ||||||
Never smoker | 237,151 | 7158 | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) |
Former smoker (0–2 years) | 17,890 | 1206 | 1.3 (1.22–1.39) | 1.21 (1.13–1.3) | 1.22 (1.15–1.31) | 1.21 (1.13–1.29) |
Former smoker (3–5 years) | 13,729 | 948 | 1.22 (1.14–1.31) | 1.15 (1.07–1.23) | 1.11 (1.04–1.2) | 1.11 (1.03–1.19) |
Former smoker (6–8 years) | 9225 | 673 | 1.16 (1.07–1.26) | 1.09 (1.001–1.18) | 1.07 (0.98–1.16) | 1.06 (0.98–1.15) |
Former smoker (9–11 years) | 11,019 | 888 | 1.08 (1–1.16) | 1.05 (0.98–1.13) | 0.98 (0.91–1.05) | 0.98 (0.91–1.06) |
Former smoker (12–46 years) | 16,580 | 1404 | 0.92 (0.86–0.98) | 0.95 (0.9–1.02) | 0.92 (0.86–0.98) | 0.92 (0.86–0.98) |
Current smoker (0–9 years) | 6583 | 284 | 1.34 (1.19–1.52) | 1.22 (1.08–1.38) | 1.29 (1.14–1.46) | 1.28 (1.13–1.44) |
Current smoker (10–14 years) | 16,889 | 817 | 1.34 (1.24–1.45) | 1.19 (1.1–1.29) | 1.2 (1.11–1.29) | 1.17 (1.08–1.26) |
Current smoker (15–19 years) | 20,017 | 1453 | 1.41 (1.32–1.5) | 1.25 (1.18–1.33) | 1.24 (1.16–1.32) | 1.22 (1.14–1.3) |
Current smoker (20–24 years) | 20,811 | 2098 | 1.46 (1.38–1.54) | 1.33 (1.26–1.41) | 1.37 (1.29–1.45) | 1.37 (1.3–1.45) |
Current smoker (25–50 years) | 16,664 | 2121 | 1.37 (1.3–1.45) | 1.34 (1.27–1.42) | 1.32 (1.25–1.4) | 1.33 (1.26–1.41) |
Smoking Status | Number | Baseline | Change (Slope) | |||||||
---|---|---|---|---|---|---|---|---|---|---|
BMI, kg/m2 | Weight, kg | Waist, cm | BMI | Weight | Waist | |||||
Number | beta | Number | beta | Number | beta | |||||
Never smoker | 237,151 (61.3%) | 22.44 ± 3.19 | 60.89 ± 11.63 | 77.51 ± 9.27 | 237,136 | 0.18 ± 0.82 | 237,136 | 0.47 ± 2.23 | 229,400 | 0.40 ± 2.96 |
Former smoker (0–2 years) | 17,890 (4.6%) | 24.39 ± 3.12 | 73.24 ± 11.33 | 85.11 ± 8.69 | 17,890 | 0.22 ± 0.79 | 17,890 | 0.65 ± 2.39 | 17,890 | 0.49 ± 2.59 |
Former smoker (3–5 years) | 13,729 (3.6%) | 24.28 ± 3.07 | 72.35 ± 11.32 | 84.53 ± 8.61 | 13,729 | 0.17 ± 0.73 | 13,729 | 0.51 ± 2.17 | 13,729 | 0.43 ± 2.45 |
Former smoker (6–8 years) | 9225 (2.4%) | 24.13 ± 3.04 | 71.60 ± 11.16 | 84.13 ± 8.54 | 9225 | 0.14 ± 0.64 | 9225 | 0.40 ± 1.90 | 9225 | 0.33 ± 2.19 |
Former smoker (9–11 years) | 11,019 (2.9%) | 24.15 ± 2.89 | 71.40 ± 10.63 | 84.19 ± 8.21 | 11,018 | 0.10 ± 0.55 | 11,018 | 0.27 ± 1.66 | 11,018 | 0.29 ± 1.96 |
Former smoker (12–46 years) | 16,580 (4.3%) | 24.10 ± 2.83 | 70.64 ± 10.34 | 84.25 ± 8.00 | 16,580 | 0.06 ± 0.56 | 16,580 | 0.13 ± 1.65 | 16,580 | 0.21 ± 2.04 |
Current smoker (0–9 years) | 6583 (1.7%) | 23.98 ± 3.38 | 71.35 ± 12.84 | 83.24 ± 9.47 | 6583 | 0.35 ± 0.99 | 6583 | 1.05 ± 2.95 | 6583 | 0.79 ± 3.07 |
Current smoker (10–14 years) | 16,889 (4.4%) | 24.32 ± 3.29 | 73.51 ± 11.90 | 84.68 ± 9.00 | 16,889 | 0.29 ± 0.77 | 16,889 | 0.89 ± 2.36 | 16,888 | 0.72 ± 2.57 |
Current smoker (15–19 years) | 20,017 (5.2%) | 24.54 ± 3.22 | 74.23 ± 11.45 | 85.58 ± 8.67 | 20,017 | 0.18 ± 0.64 | 20,017 | 0.53 ± 1.96 | 20,015 | 0.46 ± 2.21 |
Current smoker (20–24 years) | 20,811 (5.4%) | 24.56 ± 3.05 | 73.64 ± 10.72 | 85.48 ± 8.25 | 20,811 | 0.11 ± 0.54 | 20,811 | 0.32 ± 1.63 | 20,810 | 0.35 ± 1.87 |
Current smoker (25–50 years) | 16,664 (4.3%) | 24.47 ± 2.85 | 72.17 ± 9.89 | 85.58 ± 7.76 | 16,664 | 0.08 ± 0.54 | 16,664 | 0.18 ± 1.59 | 16,664 | 0.36 ± 2.07 |
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Sung, D.-E.; Lee, S.-J.; Lee, M.-Y.; Rhee, E.-J.; Sung, K.-C. Longitudinal Analysis of Diabetes Mellitus Risk: Smoking Status and Smoking Cessation. J. Clin. Med. 2024, 13, 3927. https://doi.org/10.3390/jcm13133927
Sung D-E, Lee S-J, Lee M-Y, Rhee E-J, Sung K-C. Longitudinal Analysis of Diabetes Mellitus Risk: Smoking Status and Smoking Cessation. Journal of Clinical Medicine. 2024; 13(13):3927. https://doi.org/10.3390/jcm13133927
Chicago/Turabian StyleSung, Da-Eun, Seung-Jae Lee, Mi-Yeon Lee, Eun-Jung Rhee, and Ki-Chul Sung. 2024. "Longitudinal Analysis of Diabetes Mellitus Risk: Smoking Status and Smoking Cessation" Journal of Clinical Medicine 13, no. 13: 3927. https://doi.org/10.3390/jcm13133927
APA StyleSung, D.-E., Lee, S.-J., Lee, M.-Y., Rhee, E.-J., & Sung, K.-C. (2024). Longitudinal Analysis of Diabetes Mellitus Risk: Smoking Status and Smoking Cessation. Journal of Clinical Medicine, 13(13), 3927. https://doi.org/10.3390/jcm13133927