The Utility of Novel pH-Impedance Monitoring Parameters (PSPW Index and MNBI) in Pediatric Gastroesophageal Reflux Disease Phenotypes—A Systematic Review
Abstract
1. Introduction
2. Materials and Methods
3. Results
4. Discussion
4.1. MNBI
4.2. PSPW
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Author, Publication Year | GERD Spectrum | PSPW Index % | MNBI (ohms) |
---|---|---|---|
Blasi, 2023 [29] (median, IQR) | NERD | 42.6 (29.6–45.8) | 1315 (1018–2832) |
RH | 56.3 (38.7–67.2) | 2724 (2273–3403) | |
FH | 52 (35.9–69.1) | 2576 (2115–3014) | |
Eiamkulbutr, 2023 [25] (mean, SD) | extraesophageal GERD | 56.11 (15.70) | 1300.48 (600.31) |
no extraesophageal GERD | 53.57 (27.59) | 1897.69 (806.89) | |
Tortoriello, 2023 [30] (mean, SD) | GERD | 20.11 (28.84) | 1673.11 (598.67) |
RH | 47 (29.23) | 2303 (837.8) | |
FH | 52 (43.85) | 2417 (656.23) | |
Rosado-Arias, 2022 [31] | pathological AET | 2195 | |
normal AET | 1997 | ||
Sabban, 2021 [32] (mean, SD) | RH | 48.4 ± 20.84 | 1286 ± 514.68 |
FH | 64.6 ± 38.84 | 2168 ± 449.03 | |
Rosado-Arias, 2021 [33] (mean, SD) | severe esophagitis | 1829.5 (246.7) | |
non-severe esophagitis | 2218.6 (1042.6) | ||
Sabban, 2021 [34] (median, IQR) | GER with respiratory symptoms | 47.0 (37.0–54.0) | 2461.0 (2129.0–2887.0) |
GER with digestive symptoms | 50.0 (40.6–70.6) | 2183.0 (1780.5–2527.5) | |
Di Chio, 2019 [35] (mean, SD) | GERD | 26.4 ± 18.9 | 834.3 ± 473.3 |
without evidence of GERD | 48.4 ± 22.1 | 2608.2 ± 830.9 |
Author, Publication Year | Period of Time | Number of Patients | Age: Mean ± SD or Interval | Number of Pediatric Centers | Location | Endoscopy/Histology | MII Duration (Hours) | Statistical Result | Clinical Results (Study Conclusion) |
---|---|---|---|---|---|---|---|---|---|
Blasi, 2023 [29] | Jan. 2014–Apr. 2019 | 68 | 5–17 years | 6 | Italy | yes/yes | NM |
|
|
Eiamkulbutr, 2023 [25] | Feb. 2019–Dec. 2022 | 51 | 2.24 (1.11–7.67) years | 1 | Thailand | yes/yes | 22.09 (20.20–2.41) |
|
|
Tortoriello, 2023 [30] | NM | 32 | NM | 2 | Mexico | NM | NM |
|
|
Rosado-Arias, 2022 [31] | 2015–2020 | 68 | 45 (2–216) months | 1 | Mexico | yes/yes | 22 (16–33) |
|
|
Sabban, 2021 [32] | Jan. 2017–Nov. 2020 | 60 | 11.15 (5–17) years | 1 | Argentina | yes/yes | NM |
|
|
Rosado-Arias, 2021 [33] | 2015–2020 | 68 | 45 (2–216) months | 1 | Mexico | yes/NM | NM |
|
|
Sabban, 2021 [34] | May 2018–Apr. 2021 | 92 | 8 (6.0–11.2) years | 2 | Argentina | NM | NM |
|
|
Di Chio, 2019 [35] | NM | 40 | 7.9 ± 4.2 years | 1 | NM | yes/yes | NM |
|
|
Total/mean ± SD/n (%) | 2014–2022 | 479 | 2 months–17 years | 12 | Europe, Asia, North America, South America |
Gastroesophageal Reflux Phenotype | Study | PSPW Index % | MNBI (ohms) |
---|---|---|---|
GERD | Tortoriello, 2023 [30] (mean ± SD) | 20.11 ± 28.84 | 1673.11 ± 598.67 |
Di Chio, 2019 [35] (mean ± SD) | 26.4 ± 18.9 | 834.3 ± 473.3 | |
Overall | 23.25 ± 23.87 | 1253.7 ± 535.98 | |
NERD | Blasi, 2023 [29] (median, IQR) | 42.6 (29.6–45.8) | 1315 (1018–2832) |
RH | Blasi, 2023 [29] (median, IQR) | 56.3 (38.7–67.2) | 2724 (2273–3403) |
Tortoriello, 2023 [30] (mean ± SD) | 47 ± 29.23 | 2303 ± 837.8 | |
Sabban, 2021 [32] (mean ± SD) | 48.4 ± 20.84 | 1286 ± 514.68 | |
Overall | 47.7 ± 25.03 | 1794.5 ± 676.24 | |
FH | Blasi, 2023 [29] (median, IQR) | 52 (35.9–69.1) | 2576 (2115–3014) |
Tortoriello, 2023 [30] (mean ± SD) | 52 ± 43.85 | 2417 ± 656.23 | |
Sabban, 2021 [32] (mean ± SD) | 64.6 ± 38.84 | 2168 ± 449.03 | |
Overall | 58.3 ± 41.34 | 2292.5 ± 552.63 |
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Pop, R.S.; Farcău, D.; Chiperi, L.E.; Dumitrașcu, D.L. The Utility of Novel pH-Impedance Monitoring Parameters (PSPW Index and MNBI) in Pediatric Gastroesophageal Reflux Disease Phenotypes—A Systematic Review. J. Clin. Med. 2024, 13, 3351. https://doi.org/10.3390/jcm13113351
Pop RS, Farcău D, Chiperi LE, Dumitrașcu DL. The Utility of Novel pH-Impedance Monitoring Parameters (PSPW Index and MNBI) in Pediatric Gastroesophageal Reflux Disease Phenotypes—A Systematic Review. Journal of Clinical Medicine. 2024; 13(11):3351. https://doi.org/10.3390/jcm13113351
Chicago/Turabian StylePop, Radu Samuel, Dorin Farcău, Lăcrămioara Eliza Chiperi, and Dan Lucian Dumitrașcu. 2024. "The Utility of Novel pH-Impedance Monitoring Parameters (PSPW Index and MNBI) in Pediatric Gastroesophageal Reflux Disease Phenotypes—A Systematic Review" Journal of Clinical Medicine 13, no. 11: 3351. https://doi.org/10.3390/jcm13113351
APA StylePop, R. S., Farcău, D., Chiperi, L. E., & Dumitrașcu, D. L. (2024). The Utility of Novel pH-Impedance Monitoring Parameters (PSPW Index and MNBI) in Pediatric Gastroesophageal Reflux Disease Phenotypes—A Systematic Review. Journal of Clinical Medicine, 13(11), 3351. https://doi.org/10.3390/jcm13113351