Frailty and Increased Levels of Symptom Burden Can Predict the Presence of Each Other in HNSCC Patients
Abstract
:1. Introduction
2. Patients and Methods
2.1. Statistical Considerations and Sample Size
2.2. Study Cohort
2.3. Assessment of Frailty and Symptom Burden
2.4. Statistical Analysis
3. Results
3.1. Demographic Parameters and Study Cohort
3.2. Symptoms and Symptom Burden
3.3. Correlations and ROC Analysis
4. Discussion
5. Limitations
6. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
AUC | Area under the curve |
CGA | Comprehensive geriatric assessment |
CI | Confidence interval |
CUP | Cancer of unknown primary |
G8 | Geriatric 8 (screening instrument for the assessment of frailty) |
HNSCC | Head and neck squamous cell carcinoma |
IBM | International Business Machines Corporation |
J | Youden’s J |
MIDOS2 | Minimal Documentation System 2 |
n | Sample size |
p | p-value |
ρ | Spearman’s rho |
r | Pearson’s r |
ROC | Receiver operating characteristic (used to assess the accuracy of tests in predictive models) |
SD | Standard deviation |
SPSS | Statistical Package for the Social Sciences |
Zalpha | Standardized distance from mean (according to standard deviation units) |
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n | % | ||
---|---|---|---|
Sex | Male | 49 | 83.1 |
Female | 10 | 16.9 | |
HNSCC site | Oropharynx | 23 | 39.0 |
Larynx | 15 | 25.4 | |
Oral cavity | 13 | 22.0 | |
Hypopharynx | 6 | 10.2 | |
CUP | 2 | 3.4 | |
Frailty (G8) | Robust | 18 | 30.5 |
Frail | 41 | 69.5 | |
Increased symptom burden | Yes | 27 | 45.8 |
(MIDOS2) | No | 32 | 54.2 |
Age | MIDOS2 Score | G8 | |
Mean | 62.53 | 3.86 | 12.47 |
SD | 10.23 | 3.27 | 2.70 |
Minimum | 35 | 0 | 6 |
Maximum | 81 | 12 | 17 |
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Kunz, V.; Wichmann, G.; Wald, T.; Dietz, A.; Wiegand, S. Frailty and Increased Levels of Symptom Burden Can Predict the Presence of Each Other in HNSCC Patients. J. Clin. Med. 2024, 13, 212. https://doi.org/10.3390/jcm13010212
Kunz V, Wichmann G, Wald T, Dietz A, Wiegand S. Frailty and Increased Levels of Symptom Burden Can Predict the Presence of Each Other in HNSCC Patients. Journal of Clinical Medicine. 2024; 13(1):212. https://doi.org/10.3390/jcm13010212
Chicago/Turabian StyleKunz, Viktor, Gunnar Wichmann, Theresa Wald, Andreas Dietz, and Susanne Wiegand. 2024. "Frailty and Increased Levels of Symptom Burden Can Predict the Presence of Each Other in HNSCC Patients" Journal of Clinical Medicine 13, no. 1: 212. https://doi.org/10.3390/jcm13010212
APA StyleKunz, V., Wichmann, G., Wald, T., Dietz, A., & Wiegand, S. (2024). Frailty and Increased Levels of Symptom Burden Can Predict the Presence of Each Other in HNSCC Patients. Journal of Clinical Medicine, 13(1), 212. https://doi.org/10.3390/jcm13010212