Letermovir Rescue Therapy in Kidney Transplant Recipients with Refractory/Resistant CMV Disease
Abstract
:1. Introduction
2. Materials and Methods
3. Results
3.1. Case 1
3.2. Case 2
3.3. Case 3
3.4. Case 4
3.5. Case 5
3.6. Case 6
3.7. Case 7
3.8. Case 8
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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GFR after CMV | Best GFR before CMV | LTV Resistance | Additional/Parallel Therapy | LTV to Clearing (w) | LTV to <2000 cop/mL (w) | LTV (w) | VGCV/GCV Resistance | VGCV/GCV Treatment to LTV (w) | VGCV Prophylaxis Discontinued | CMV under Prophylaxis | CMV > 2000 cop/mL after Tx (w) | CMV Infection | Serostatus Prior to CMV | Rejection | IS Prior to r/r CMV | Intensified IS | DD/LD | Initial IS | Age at Tx (y) | Sex | Case | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
50 mL/min | 38 mL/min | No | Yes, LTV + VGCV | 30.7 | 1.4 | 34.4 | Yes, UL97:C603W | 35.1 | No | Yes | 27.0 | 1° | D+/R− | No | Belatacept, MMF 2 g/d, Urbason | No | LD | Basiliximab, CNI, MMF, Urbason | 30 | M | 1 | |
36 mL/min | 30 mL/min | No | No | No clearing | 6.0 | 6.0 | Yes, UL97:H520Q | 9.1 | No | Yes | 18.0 | 1° | D+/R− | No | CNI, MMF 2 g/d, Urbason | No | DD | Basiliximab, CNI, MMF, Urbason | 71 | W | 2 | |
20 mL/min | 16 mL/min | No | No | No clearing | 19.7 | 24.4 | Yes, UL97:A594T | 4.7 | No | Yes | 18.4 | 1° | D+/R− | No | CNI, MMF 1 g/d, Urbason | No | DD | Basiliximab, CNI MMF, Urbason | 52 | M | 3 | |
70 mL/min | 25 mL/min | No | Yes, LTV + VGCV | 38.9 | 14.7 | 41.1 | Yes, UL97:C603W | 13.1 | No | Yes | 9.4 | 1° | D+/R− | No | CNI, MMF 2 g/d, Urbason | No | DD | Basiliximab, CNI, MMF, Urbason | 44 | M | 4 | |
18 mL/min | 20 mL/min | No | Yes, VGCV + | Cytotect | 16.3 | - | 16.4 | Yes, UL97:H469Y, L595F | 2.7 | Yes, 3 w | No | 274.6 | 2° | D+/R− | No | CSA, Urbason | No | DD | Basiliximab, CSA, MMF, Urbason | 74 | M | 5 |
36 mL/min | 40 mL/min | No | No | 16.7 | - | 8.1 | Yes, UL97:A594V | 14.9 | No | Yes | 8.3 | 1° | D+/R− | No | CNI, MMF 1 g/d, Urbason | No | DD | Basiliximab, CNI, MMF, Urbason | 63 | M | 6 | |
<15 mL/min | <15 mL/min | Yes, UL56:C325Y, C325F | Yes, VGCV + Cytotect | - | - | 7.6 | No | 9.3 | No | Yes | 22.6 | 1° | D+/R− | Yes | Belatacept, MMF 2 g/d, Urbason | Yes, Methylprednisolone bolus | DD | Basiliximab, CNI, MMF, Urbason | 53 | W | 7 | |
60 mL/min | 51 mL/min | Yes | Yes, VGCV + Cytotect | - | - | 9.7 | Yes, UL97:A594V | 15.1 | No | Yes | 79.7 | Recurrent infection | D−R+ | Yes | Belatacept, MMF 1 g/d, Urbason | Yes, Methylprednisolone bolus, ATG | DD | Basiliximab, CNI, MMF, Urbason | 52 | W | 8 |
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von Hoerschelmann, E.; Münch, J.; Gao, L.; Lücht, C.; Naik, M.G.; Schmidt, D.; Pitzinger, P.; Michel, D.; Avaniadi, P.; Schrezenmeier, E.; et al. Letermovir Rescue Therapy in Kidney Transplant Recipients with Refractory/Resistant CMV Disease. J. Clin. Med. 2024, 13, 100. https://doi.org/10.3390/jcm13010100
von Hoerschelmann E, Münch J, Gao L, Lücht C, Naik MG, Schmidt D, Pitzinger P, Michel D, Avaniadi P, Schrezenmeier E, et al. Letermovir Rescue Therapy in Kidney Transplant Recipients with Refractory/Resistant CMV Disease. Journal of Clinical Medicine. 2024; 13(1):100. https://doi.org/10.3390/jcm13010100
Chicago/Turabian Stylevon Hoerschelmann, Ellen, Johannes Münch, Linde Gao, Christian Lücht, Marcel G. Naik, Danilo Schmidt, Paul Pitzinger, Detlef Michel, Parthenopi Avaniadi, Eva Schrezenmeier, and et al. 2024. "Letermovir Rescue Therapy in Kidney Transplant Recipients with Refractory/Resistant CMV Disease" Journal of Clinical Medicine 13, no. 1: 100. https://doi.org/10.3390/jcm13010100
APA Stylevon Hoerschelmann, E., Münch, J., Gao, L., Lücht, C., Naik, M. G., Schmidt, D., Pitzinger, P., Michel, D., Avaniadi, P., Schrezenmeier, E., Choi, M., Halleck, F., & Budde, K. (2024). Letermovir Rescue Therapy in Kidney Transplant Recipients with Refractory/Resistant CMV Disease. Journal of Clinical Medicine, 13(1), 100. https://doi.org/10.3390/jcm13010100