Promising Perinatal Outcome after Using a Simplified Low-Cost IVF Culture System Specifically Designed for Resource-Poor Countries
Abstract
:1. Introduction
2. Materials and Methods
2.1. The Simplified Culture System (SCS)
2.2. Comparative Medical Economics of IVF Systems
2.3. The SCS Patient Cohort: Materials and Methods
2.4. The SCS Patient Cohort: Outcome Parameters
2.5. Comparison with BELRAP Data
2.6. Ethical Committee Approval
2.7. Statistics
3. Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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All IVF/ICSI (BELRAP) | SCS | p Value (Fisher’s Exact Test) | ||
---|---|---|---|---|
Gestational age at delivery | 0.0549 | |||
<37 weeks | 1505 (9.2) | 4 (3.8) | ||
≥37 weeks | 14,783 (91.8) | 101 (96.2) | ||
Birthweight | 0.0399 | |||
< 2.5 kg | 1338 (8.4) | 3 (2.9) | ||
≥2.5 kg | 14,521 (91.6) | 102 (97.1) |
All IVF/ICSI (BELRAP) | SCS | p Value (Fisher’s Exact Test) | ||
---|---|---|---|---|
Gestational age at delivery | 0.6454 | |||
<37 weeks | 1154 (10.1) | 6 (8.4) | ||
≥37 weeks | 10,264 (89.9) | 65 (91.6) | ||
Birthweight | 0.7210 | |||
<2.5 kg | 573 (5.2) | 3 (4.2) | ||
≥2.5 kg | 10,514 (94.8) | 68 (95.8) |
IVF Only (BELRAP) | SCS | p Value (Fisher’s Exact Test) | ||
---|---|---|---|---|
Gestational age at delivery | 0.0296 | |||
<37 weeks | 272 (10.2) | 4 (3.8) | ||
≥37 weeks | 2406 (89.8) | 101 (96.2) | ||
Birthweight | 0.0161 | |||
<2.5 kg | 264 (9.8) | 3 (2.9) | ||
≥2.5 kg | 2431 (90.2) | 102 (97.1) |
OR (95% CI) BELRAP vs. SCS | p Value (Logistic Model) | |
---|---|---|
Gestational age at delivery < 37 w | ||
No correction for risk factors | 2.852 [1.042; 7.803] | 0.0413 |
Correction for risk factors | 2.627 [1.013; 6.816] | 0.0471 |
Birth weight < 2.5 kg | ||
No correction for risk factors Correction for risk factors | 3.692 [1.163; 11.721] 3.267 [1.118; 9.549] | 0.0267 0.0305 |
IVF only (BELRAP) | SCS | p Value | ||
---|---|---|---|---|
Age of mother (years) | 0.7615 | |||
<25 | 64 (2.4) | 3 (2.9) | ||
25–29 | 539 (20.0) | 21 (20.0) | ||
30–34 | 1116 (41.4) | 42 (40.0) | ||
35–39 | 742 (27.5) | 33 (31.4) | ||
≥40 | 234 (8.7) | 6 (5.7) | ||
Day of transfer | 0.0001 | |||
2–3 | 1751 (65.0) | 33 (31.4) | ||
4–5 | 943 (35.0) | 72 (68.6) | ||
Pituitary inhibition | 0.0001 | |||
Agonist long | 1016 (37.8) | 14 (13.3) | ||
Agonist short | 408 (15.2) | 11 (10.5) | ||
Antagonist | 1265 (47.0) | 80 (76.2) | ||
Rank of fresh cycle | 0.1691 | |||
1 | 1445 (53.7) | 49 (46.7) | ||
2 | 696 (25.9) | 30 (28.6) | ||
3 | 292 (10.9) | 18 (17.1) | ||
>3 | 257 (9.6) | 8 (7.6) | ||
Number of oocytes retrieved | 0.0001 | |||
<6 | 761 (28.2) | 4 (3.8) | ||
6–10 | 1083 (40.2) | 50 (47.6) | ||
11–15 | 609 (22.6) | 36 (34.3) | ||
16–20 | 190 (7.1) | 11 (10.5) | ||
>20 | 52 (1.9) | 4 (3.8) | ||
Number of embryos transferred | 0.0029 | |||
1 | 1970 (73.2) | 92 (87.6) | ||
2 | 650 (24.1) | 12 (11.4) | ||
≥3 | 73 (2.7) | 1 (1.0) | ||
Gender of baby | 0.1347 | |||
Male | 1429 (53.3) | 64 (61.0) | ||
Female | 1254 (46.7) | 41 (39.0) |
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Ombelet, W.; Van Blerkom, J.; Bruckers, L.; Dhont, N.; Nargund, G.; Campo, R. Promising Perinatal Outcome after Using a Simplified Low-Cost IVF Culture System Specifically Designed for Resource-Poor Countries. J. Clin. Med. 2023, 12, 2264. https://doi.org/10.3390/jcm12062264
Ombelet W, Van Blerkom J, Bruckers L, Dhont N, Nargund G, Campo R. Promising Perinatal Outcome after Using a Simplified Low-Cost IVF Culture System Specifically Designed for Resource-Poor Countries. Journal of Clinical Medicine. 2023; 12(6):2264. https://doi.org/10.3390/jcm12062264
Chicago/Turabian StyleOmbelet, Willem, Jonathan Van Blerkom, Liesbeth Bruckers, Nathalie Dhont, Geeta Nargund, and Rudi Campo. 2023. "Promising Perinatal Outcome after Using a Simplified Low-Cost IVF Culture System Specifically Designed for Resource-Poor Countries" Journal of Clinical Medicine 12, no. 6: 2264. https://doi.org/10.3390/jcm12062264