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Article

Histocompatibility Leukocyte Antigen-A29-Associated Retinal Vasculitis without Choroidal Lesions: A Report of 4 Cases

by
Estefanía Ramírez-Márquez
1,
Sofía C. Ayala Rodríguez
1,
Alejandra Santiago
1,
Edgar De Jesus
1,
Guillermo A. Requejo Figueroa
1,
Mona M. Riskalla
2,
Meghan E. Ryan
2,
Dara Koozekanani
3 and
Armando L. Oliver
1,*
1
Department of Ophthalmology, School of Medicine, Medical Sciences Campus, University of Puerto Rico, San Juan, PR 00936, USA
2
Division of Pediatric Rheumatology, Allergy, and Immunology, Department of Pediatrics, University of Minnesota Medical School Twin Cities, Minneapolis, MN 55455, USA
3
Department of Ophthalmology and Visual Neurosciences, University of Minnesota Medical School Twin Cities, Minneapolis, MN 55455, USA
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2023, 12(22), 7023; https://doi.org/10.3390/jcm12227023
Submission received: 7 October 2023 / Revised: 27 October 2023 / Accepted: 6 November 2023 / Published: 10 November 2023
(This article belongs to the Section Ophthalmology)
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Abstract

This study describes a cohort of patients presenting with histocompatibility leukocyte antigen (HLA)-A29-associated retinal vasculitis without choroidal lesions that may share clinical features with birdshot retinochoroiditis. The methods include a retrospective chart review of patients presenting with HLA-A29-associated retinal vasculitis without choroidal lesions. The data on the patients were entered retrospectively into a new database and analyzed. Four patients who had HLA-A29-associated retinal vasculitis without choroidal lesions were identified. The median age at presentation was 40 years (range: 14–71); 75% were female. At presentation, all four patients had a visual acuity of 20/50 or better in both eyes. All the eyes had mild vitritis, three eyes (37.5%) had cystoid macular edema, and two eyes (25%) had optic disc edema. All the patients required treatment with systemic steroids and immunosuppressive therapy. HLA-A29-associated retinal vasculitis without choroidal lesions appears to share many clinical features with birdshot chorioretinitis, including the need for systemic immunosuppressive therapy. Whether this entity represents an early form of birdshot retinochoroiditis or a more localized variant of the disease is a topic for additional studies.
Keywords: birdshot retinochoroidopathy; HLA-A29; retinal vasculitis birdshot retinochoroidopathy; HLA-A29; retinal vasculitis

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MDPI and ACS Style

Ramírez-Márquez, E.; Ayala Rodríguez, S.C.; Santiago, A.; De Jesus, E.; Requejo Figueroa, G.A.; Riskalla, M.M.; Ryan, M.E.; Koozekanani, D.; Oliver, A.L. Histocompatibility Leukocyte Antigen-A29-Associated Retinal Vasculitis without Choroidal Lesions: A Report of 4 Cases. J. Clin. Med. 2023, 12, 7023. https://doi.org/10.3390/jcm12227023

AMA Style

Ramírez-Márquez E, Ayala Rodríguez SC, Santiago A, De Jesus E, Requejo Figueroa GA, Riskalla MM, Ryan ME, Koozekanani D, Oliver AL. Histocompatibility Leukocyte Antigen-A29-Associated Retinal Vasculitis without Choroidal Lesions: A Report of 4 Cases. Journal of Clinical Medicine. 2023; 12(22):7023. https://doi.org/10.3390/jcm12227023

Chicago/Turabian Style

Ramírez-Márquez, Estefanía, Sofía C. Ayala Rodríguez, Alejandra Santiago, Edgar De Jesus, Guillermo A. Requejo Figueroa, Mona M. Riskalla, Meghan E. Ryan, Dara Koozekanani, and Armando L. Oliver. 2023. "Histocompatibility Leukocyte Antigen-A29-Associated Retinal Vasculitis without Choroidal Lesions: A Report of 4 Cases" Journal of Clinical Medicine 12, no. 22: 7023. https://doi.org/10.3390/jcm12227023

APA Style

Ramírez-Márquez, E., Ayala Rodríguez, S. C., Santiago, A., De Jesus, E., Requejo Figueroa, G. A., Riskalla, M. M., Ryan, M. E., Koozekanani, D., & Oliver, A. L. (2023). Histocompatibility Leukocyte Antigen-A29-Associated Retinal Vasculitis without Choroidal Lesions: A Report of 4 Cases. Journal of Clinical Medicine, 12(22), 7023. https://doi.org/10.3390/jcm12227023

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