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Journal of Clinical Medicine, Volume 12, Issue 22

2023 November-2 - 241 articles

Cover Story: Sodium-glucose cotransporter 2 inhibitors (SGLT2is) are a class of antidiabetic agents known to exert cardioprotective, renoprotective, and hypoglycemic effects. To obtain maximal benefits, uninterrupted SGLT2i therapy is essential. However, these agents have been associated with adverse effects, which results in drug discontinuation. Herein, we aimed to determine the reasons for discontinuing treatment with SGLT2is among Japanese patients with diabetes. This retrospective cohort study enrolled 766 patients. The follow-up period was 2 years from the initiation of the SGLT2is. Overall, 97 patients (12.7%) discontinued the SGLT2is. The most common reasons for discontinuation were frequent urination (19.6%), followed by genital infection (11.3%), and renal dysfunction (8.2%). To avoid discontinuation, precautions against various factors that may cause frequent urination must be implemented. View this paper
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Articles (241)

  • Review
  • Open Access
4 Citations
3,559 Views
22 Pages

Trend of Outcome Metrics in Recent Out-of-Hospital-Cardiac-Arrest Research: A Narrative Review of Clinical Trials

  • Natalie N. Htet,
  • Daniel Jafari,
  • Jennifer A. Walker,
  • Ali Pourmand,
  • Anna Shaw,
  • Khai Dinh and
  • Quincy K. Tran

20 November 2023

Cardiopulmonary resuscitation (CPR) research traditionally focuses on survival. In 2018, the International Liaison Committee on Resuscitation (ILCOR) proposed more patient-centered outcomes. Our narrative review assessed clinical trials after 2018 to...

(This article belongs to the Special Issue Cardiopulmonary Resuscitation in Emergency Medicine: What Have We Learned and How Do We Move On?)
  • Article
  • Open Access
4 Citations
2,349 Views
10 Pages

Do Barrier Films Impact Long-Term Skin Toxicity following Whole-Breast Irradiation? Objective Follow-Up of Two Randomised Trials

  • Cas Stefaan Dejonckheere,
  • Kira Lindner,
  • Anne Bachmann,
  • Alina Abramian,
  • Katharina Layer,
  • Teresa Anzböck,
  • Julian Philipp Layer,
  • Gustavo Renato Sarria,
  • Davide Scafa and
  • Leonard Christopher Schmeel
  • + 4 authors

20 November 2023

Purpose: Hydrofilm, a polyurethane-based barrier film, can be used to prevent acute radiation dermatitis (RD) in adjuvant whole-breast irradiation (WBI) for breast cancer. This cost-effective prophylactic measure is currently being recommended to a g...

(This article belongs to the Special Issue Prevention and Treatment of Skin Pigmentation Disorders)
  • Systematic Review
  • Open Access
59 Citations
13,657 Views
23 Pages

Treatment Approaches to Molar Incisor Hypomineralization: A Systematic Review

  • Angelo Michele Inchingolo,
  • Alessio Danilo Inchingolo,
  • Fabio Viapiano,
  • Anna Maria Ciocia,
  • Irene Ferrara,
  • Anna Netti,
  • Gianna Dipalma,
  • Andrea Palermo and
  • Francesco Inchingolo

20 November 2023

Aim: This systematic review aimed to comprehensively evaluate the available literature on treating molar incisor hypomineralization (MIH) or enamel hypomineralization published between 2013 and 2023, focusing on identifying relevant studies and their...

(This article belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
  • Article
  • Open Access
4 Citations
3,198 Views
9 Pages

Validity of a Mobile Application to Diagnose Temporomandibular Disorders

  • Yoo-Ree Hong,
  • Na-Kyung Hwangbo,
  • Alec-Hyung Kim and
  • Seong-Taek Kim

20 November 2023

This study aimed to assess the diagnostic accuracy of a mobile application by comparing its diagnoses to those of Orofacial Pain and Oral Medicine specialists and further imaging results (CBCT and MRI) in 500 patients with temporomandibular disorder...

(This article belongs to the Special Issue Clinical Management of Oral Healthcare in Diverse Patient Populations)
  • Article
  • Open Access
7 Citations
3,282 Views
12 Pages

Oral Health-Related Quality of Life in Adult Patients with Depression or Attention Deficit Hyperactivity Disorder (ADHD)

  • Stephan Gemp,
  • Dirk Ziebolz,
  • Rainer Haak,
  • Nicole Mauche,
  • Madlen Prase,
  • Ezgi Dogan-Sander,
  • Frauke Görges,
  • Maria Strauß and
  • Gerhard Schmalz

20 November 2023

The aim of this cross-sectional study was the evaluation of the oral health-related quality of life (OHRQoL) in patients with depression or attention-deficit/hyperactivity disorder (ADHD) in comparison with a group of mentally healthy individuals. Pa...

(This article belongs to the Section Mental Health)
  • Article
  • Open Access
4 Citations
2,761 Views
12 Pages

Low Energy Intake Diagnosed Using the Harris–Benedict Equation Is Associated with Poor Prognosis in Elderly Heart Failure Patients

  • Akira Taruya,
  • Tsuyoshi Nishiguchi,
  • Shingo Ota,
  • Motoki Taniguchi,
  • Manabu Kashiwagi,
  • Yasutsugu Shiono,
  • Ke Wan,
  • Yasushi Ino and
  • Atsushi Tanaka

20 November 2023

Introduction: Insufficient nutrient intake is a strong independent predictor of mortality in elderly patients with heart failure. However, it is unclear to what extent energy intake affects their prognosis. This study investigated the association bet...

(This article belongs to the Special Issue Acute Heart Failure: Risk Prediction, Diagnosis, and Clinical Management)
  • Article
  • Open Access
2 Citations
2,451 Views
10 Pages

20 November 2023

Background: By using outcome prediction scores, it is possible to distinguish between good and poor performers with cochlear implants (CI) after CI implantation. The reasons for poor performance, despite good basic conditions, can be manifold. On the...

(This article belongs to the Special Issue Clinical Management of Audiological Disorders: Outcome Measure in Demanding Listening Situation after CI Provision)
  • Article
  • Open Access
1 Citations
2,382 Views
11 Pages

The Association between Direct Oral Anticoagulants Prescribing Behavior and Non-Valvular Atrial Fibrillation Outcomes: An Instrumental Variable Analysis of Real-World Data

  • Nipun Atreja,
  • Stevan Geoffrey Severtson,
  • Jenny Jiang,
  • Chuan Gao,
  • Dionne M. Hines,
  • Dong Cheng,
  • Melissa Hagan,
  • Janis L. Breeze,
  • Jessica K. Paulus and
  • Eric A. Secemsky

20 November 2023

Several observational studies have compared apixaban with rivaroxaban in patients with non-valvular atrial fibrillation (NVAF), but these analyses may be confounded by unmeasured characteristics. This study used provider prescribing preference (PPP)...

(This article belongs to the Section Cardiovascular Medicine)
  • Article
  • Open Access
4 Citations
4,998 Views
9 Pages

20 November 2023

Background: It is not clear whether rehabilitation after surgery for trigger finger is effective. The aim of this study was to reveal its effectiveness for trigger finger. Methods: This study was a randomized, controlled trial that included patients...

(This article belongs to the Special Issue Hand and Wrist Surgery: Challenges and New Perspectives)
  • Article
  • Open Access
24 Citations
17,156 Views
11 Pages

Detection of Periodontal Bone Loss on Periapical Radiographs—A Diagnostic Study Using Different Convolutional Neural Networks

  • Patrick Hoss,
  • Ole Meyer,
  • Uta Christine Wölfle,
  • Annika Wülk,
  • Theresa Meusburger,
  • Leon Meier,
  • Reinhard Hickel,
  • Volker Gruhn,
  • Marc Hesenius and
  • Helena Dujic
  • + 1 author

20 November 2023

Interest in machine learning models and convolutional neural networks (CNNs) for diagnostic purposes is steadily increasing in dentistry. Here, CNNs can potentially help in the classification of periodontal bone loss (PBL). In this study, the diagnos...

(This article belongs to the Special Issue Stomatognathic Diseases: State of the Art and Future Perspectives)
  • Article
  • Open Access
9 Citations
4,079 Views
12 Pages

The Comparison of Endovascular and Open Surgical Treatment for Ruptured Abdominal Aortic Aneurysm in Terms of Safety and Efficacy on the Basis of a Single-Center 30-Year Experience

  • Mansur Duran,
  • Amir Arnautovic,
  • Cem Kilic,
  • Julian-Dario Rembe,
  • Joscha Mulorz,
  • Hubert Schelzig,
  • Markus Udo Wagenhäuser and
  • Waseem Garabet

20 November 2023

Objective: Ruptured abdominal aortic aneurysm (rAAA) is a critical condition with a high mortality rate. Over the years, endovascular aortic repair (EVAR) has evolved as a viable treatment option in addition to open repair (OR). The primary objective...

(This article belongs to the Section Vascular Medicine)
  • Review
  • Open Access
8 Citations
6,542 Views
23 Pages

Pediatric Bone Marrow Failure: A Broad Landscape in Need of Personalized Management

  • Lotte T. W. Vissers,
  • Mirjam van der Burg,
  • Arjan C. Lankester,
  • Frans J. W. Smiers,
  • Marije Bartels and
  • Alexander B. Mohseny

20 November 2023

Irreversible severe bone marrow failure (BMF) is a life-threatening condition in pediatric patients. Most important causes are inherited bone marrow failure syndromes (IBMFSs) and (pre)malignant diseases, such as myelodysplastic syndrome (MDS) and (i...

(This article belongs to the Section Hematology)
  • Review
  • Open Access
2 Citations
7,562 Views
16 Pages

Evolution of a Pathogenic Microbiome

  • Pui Yin Wong,
  • Carmen Yip,
  • Daniel A. Lemberg,
  • Andrew S. Day and
  • Steven T. Leach

20 November 2023

The process of microbiome development arguably begins before birth. Vertical transmission of bacteria from the mother to the infant is a keystone event in microbiome development. Subsequent to birth, the developing microbiome is vulnerable to influen...

(This article belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
  • Article
  • Open Access
8 Citations
2,549 Views
14 Pages

Cardiac Magnetic Resonance Identifies Responders to Cardiac Resynchronization Therapy with an Assessment of Septal Scar and Left Ventricular Dyssynchrony

  • Camilla Kjellstad Larsen,
  • Otto A. Smiseth,
  • Jürgen Duchenne,
  • Elena Galli,
  • John Moene Aalen,
  • Mathieu Lederlin,
  • Jan Bogaert,
  • Erik Kongsgaard,
  • Cecilia Linde and
  • Einar Hopp
  • + 3 authors

20 November 2023

Background: The response to cardiac resynchronization therapy (CRT) depends on septal viability and correction of abnormal septal motion. This study investigates if cardiac magnetic resonance (CMR) as a single modality can identify CRT responders wit...

(This article belongs to the Special Issue Advances in Clinical Cardiovascular Magnetic Resonance Imaging)
  • Article
  • Open Access
9 Citations
2,970 Views
12 Pages

The “Aging Effect” of BMI on Cardiorespiratory Fitness: A New Insight on Functional Evaluation in Obesity

  • Francesca Battista,
  • Daniel Neunhaeuserer,
  • Anna Centanini,
  • Andrea Gasperetti,
  • Giulia Quinto,
  • Marco Vecchiato,
  • Elia Bianchi,
  • Anna Chiara Frigo,
  • Silvia Bettini and
  • Andrea Ermolao
  • + 2 authors

20 November 2023

Cardiorespiratory fitness (CRF) is a strong predictor of morbidity and mortality in patients with obesity. This study investigates the CRF range and its clinical determinants in patients with obesity. Moreover, a practical proposal for CRF interpreta...

(This article belongs to the Section Sports Medicine)
  • Comment
  • Open Access
2 Citations
1,338 Views
3 Pages

20 November 2023

We read with interest the recent article by Killian et al. regarding the characteristics and treatment of brain vascular malformations (VMs) in children and adults with hereditary hemorrhagic telangiectasia (HHT) [...]

(This article belongs to the Special Issue Hereditary Hemorrhagic Telangiectasia: Diagnosis and Management—Part II)
  • Article
  • Open Access
24 Citations
10,195 Views
22 Pages

Nutrition and Mental Well-Being: Exploring Connections and Holistic Approaches

  • Theodora Claudia Gheonea,
  • Carmen-Nicoleta Oancea,
  • Magdalena Mititelu,
  • Elena Carmen Lupu,
  • Corina-Bianca Ioniță-Mîndrican and
  • Ion Rogoveanu

20 November 2023

Quality of life, well-being, and psycho-emotional balance are closely related to the quality of the diet, the level of physical activity, the quality of rest, but also the absence of the consumption of narcotic substances and tobacco, or alcohol abus...

(This article belongs to the Special Issue Updates in Liver Cirrhosis)
  • Article
  • Open Access
5 Citations
2,385 Views
13 Pages

Nutritional Risk Assessment and Adverse Events in Patients Undergoing Left Ventricular Assist Device Implantation—A Retrospective Cohort Study Using Hospital Information System

  • Irena Milaniak,
  • Lucyna Tomaszek,
  • Sylwia Wiśniowska-Śmiałek,
  • Izabela Górkiewicz-Kot,
  • Grzegorz Wasilewski,
  • Paulina Kurleto,
  • Michał Kaleta,
  • Dorota Sobczyk and
  • Karol Wierzbicki

20 November 2023

Clinical or subclinical malnutrition occurs in 30% to 70% of patients with advanced heart failure and increases the risk of postoperative adverse events. The main objective of this study was to assess the nutritional status of patients prior to left...

(This article belongs to the Topic Mechanical Circulatory Support in Heart Failure)
  • Case Report
  • Open Access
5 Citations
7,417 Views
13 Pages

Tenofovir-Induced Fanconi Syndrome Presenting with Life-Threatening Hypokalemia: Review of the Literature and Recommendations for Early Detection

  • Efstathia Liatsou,
  • Ioanna Tatouli,
  • Andreas Mpozikas,
  • Maria-Markella Pavlou,
  • Hariklia Gakiopoulou,
  • Ioannis Ntanasis-Stathopoulos,
  • Maria Gavriatopoulou,
  • Sofoklis Kontogiannis and
  • Meletios Athanasios Dimopoulos

20 November 2023

Tenofovir disoproxil fumarate (TDF) is a nucleotide reverse transcriptase inhibitor that has been widely used for the treatment of patients with human immunodeficiency virus (HIV) and hepatitis B virus (HBV) infections. Despite the excellent safety r...

(This article belongs to the Special Issue Acute Kidney Injury: Advances in Clinical Management)
  • Article
  • Open Access
11 Citations
3,306 Views
14 Pages

Recurrent Atrial Fibrillation Ablation after Initial Successful Pulmonary Vein Isolation

  • Julian Müller,
  • Karin Nentwich,
  • Artur Berkovitz,
  • Kai Sonne,
  • Olena Kozlova,
  • Sebastian Barth,
  • Alexandru Deacanu,
  • Christian Waechter,
  • Philipp Halbfass and
  • Thomas Deneke
  • + 1 author

19 November 2023

Background: Pulmonary vein isolation (PVI) is an effective treatment option for patients with symptomatic atrial fibrillation (AF). However, the electrical recovery of pulmonary veins (PVs) is the main trigger for AF recurrences. This study investiga...

(This article belongs to the Section Cardiology)
  • Review
  • Open Access
21 Citations
33,238 Views
14 Pages

Endo Belly: What Is It and Why Does It Happen?—A Narrative Review

  • Renata Voltolini Velho,
  • Franziska Werner and
  • Sylvia Mechsner

19 November 2023

Endometriosis is a chronic inflammatory disease where endometrial-like lesions settle outside the uterus, resulting in extensive inflammatory reactions. It is a complex disease that presents with a range of symptoms, with pain and infertility being t...

(This article belongs to the Section Obstetrics & Gynecology)
  • Article
  • Open Access
4 Citations
2,178 Views
17 Pages

Topographical Correlation between Structural and Functional Impairment of the Macular Inner Retinal Layers in Multiple Sclerosis Eyes with a History of Optic Neuropathy

  • Vincenzo Parisi,
  • Lucilla Barbano,
  • Giulio Antonelli,
  • Carolina Gabri Nicoletti,
  • Doriana Landi,
  • Giorgia Mataluni,
  • Antonio Di Renzo,
  • Fabio Buttari,
  • Girolama Alessandra Marfia and
  • Lucia Ziccardi
  • + 1 author

19 November 2023

We investigated the potential correlation between morphological and functional parameters describing the rarefaction and dysfunction of retinal ganglion cells (RGCs), located in the macula, in multiple sclerosis eyes with a history of optic neuritis...

(This article belongs to the Section Ophthalmology)
  • Article
  • Open Access
12 Citations
3,524 Views
14 Pages

Dynamic Assessment of Plasma von Willebrand Factor and ADAMTS13 Predicts Mortality in Hospitalized Patients with SARS-CoV-2 Infection

  • Quan Zhang,
  • Antonia Bignotti,
  • Noritaka Yada,
  • Zhan Ye,
  • Szumam Liu,
  • Zhe Han and
  • X. Long Zheng

19 November 2023

Background: Plasma levels of von Willebrand factor (VWF) are significantly elevated in patients with coronavirus disease 2019 (COVID-19). However, dynamic changes and prognostic value of this biomarker in hospitalized patients with COVID-19 have not...

(This article belongs to the Topic Advances in COVID-19 and Cancer)
  • Review
  • Open Access
4 Citations
2,658 Views
11 Pages

19 November 2023

Heparin and derivatives are commonly used for thrombophylaxis in surgical colorectal cancer (CRC) patients. Recent studies have suggested that, besides its protective effect on the incidence of venous thromboembolism, heparin has an anti-cancer effec...

(This article belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
  • Article
  • Open Access
7 Citations
2,051 Views
13 Pages

Factors Affecting the Duration of Surgery in the Management of Condylar Head Fractures

  • Simon Patrik Pienkohs,
  • Axel Meisgeier,
  • Johannes Herrmann,
  • Leontine Graf,
  • Clarissa S. Reichert,
  • Guilherme Trento and
  • Andreas Neff

19 November 2023

Prolonged operation times should be avoided due to the associated complications and negative effects on the efficiency of the use of operating room resources. Surgical treatment of mandibular condylar head fractures is a well-established routine proc...

(This article belongs to the Special Issue Updates and Challenges in Maxillo-Facial Surgery)
  • Article
  • Open Access
4 Citations
5,729 Views
15 Pages

Clinical Aspects in Subacute Thyroiditis: A Real-Life Study on 226 Cases in Greece Amid the COVID-19 Pandemic

  • Nikolaos Angelopoulos,
  • Dimitrios P. Askitis,
  • Ioannis Androulakis,
  • Nicolas Valvis,
  • Rodis Paparodis,
  • Valentina Petkova,
  • Anastasios Boniakos,
  • Dimitra Zianni,
  • Ilias Perogamvros and
  • Ioannis Iakovou
  • + 2 authors

18 November 2023

Purpose: This study aimed to evaluate various therapeutic approaches, identify potential predictive factors for the recurrence and development of hypothyroidism, and examine specific clinical and laboratory characteristics of patients with subacute t...

(This article belongs to the Section Endocrinology & Metabolism)
  • Article
  • Open Access
2 Citations
2,391 Views
14 Pages

Stress Dynamics in Families with Children with Neuropsychiatric Disorders during the COVID-19 Pandemic: A Three-Year Longitudinal Assessment

  • Ada Claudia Silvana Gruescu,
  • Calin Popoiu,
  • Mihaela Codrina Levai,
  • Sonia Roxana Burtic,
  • Isabella Ionela Sanda,
  • Oana Neda-Stepan,
  • Ovidiu Rosca,
  • Roxana Manuela Fericean,
  • Catalin Dumitru and
  • Lavinia Stelea

18 November 2023

Background and Objectives: This study explores the impact of the COVID-19 pandemic on families with children diagnosed with neuropsychiatric disorders, focusing on stress dynamics and quality of life. Materials and Methods: A longitudinal survey was...

(This article belongs to the Special Issue Global Burden and New Trends in Emotional, Behavioral and Relational Problems of Children, Adolescents and Young Adults)
  • Article
  • Open Access
4 Citations
3,115 Views
10 Pages

The CHANGED Score—A New Tool for the Prediction of Insulin Dependency in Gestational Diabetes

  • Paul Rostin,
  • Selina Balke,
  • Dorota Sroka,
  • Laura Fangmann,
  • Petra Weid,
  • Wolfgang Henrich and
  • Josefine Theresia Königbauer

18 November 2023

Gestational diabetes (GDM) is a frequent complication during pregnancy. We aimed to develop a score to predict future insulin dependency in gestational diabetes (GDM). Data from 1611 patients from Charité Berlins gestational diabetes clinic fr...

(This article belongs to the Section Obstetrics & Gynecology)
  • Article
  • Open Access
1 Citations
3,332 Views
14 Pages

External Validation and Recalibration of a Mortality Prediction Model for Patients with Ischaemic Stroke

  • Juan Manuel García-Torrecillas,
  • María Carmen Lea-Pereira,
  • Laura Amaya-Pascasio,
  • Carmen Rosa-Garrido,
  • Miguel Quesada-López,
  • Fernando Reche-Lorite,
  • Mar Iglesias-Espinosa,
  • Adrián Aparicio-Mota,
  • José Galván-Espinosa and
  • Miguel Rodríguez-Barranco
  • + 1 author

18 November 2023

Background: Stroke is a highly prevalent disease that can provoke severe disability. We evaluate a predictive model based on the Minimum Basic Data Set (MBDS) compiled by the Spain Health Ministry, obtained for the period 2008–2012 for patients...

(This article belongs to the Section Clinical Neurology)
  • Article
  • Open Access
14 Citations
2,686 Views
12 Pages

Pulmonary Lobectomy for Early-Stage Lung Cancer with Uniportal versus Three-Portal Video-Assisted Thoracic Surgery: Results from a Single-Centre Randomized Clinical Trial

  • Davide Tosi,
  • Alessandra Mazzucco,
  • Valeria Musso,
  • Gianluca Bonitta,
  • Lorenzo Rosso,
  • Paolo Mendogni,
  • Ilaria Righi,
  • Rosaria Carrinola,
  • Francesco Damarco and
  • Alessandro Palleschi

18 November 2023

Video-assisted thoracic surgery (VATS) is a consolidated approach; however, there is no consensus on the number of ports leading to less postoperative pain. We compared early postoperative pain after uniportal and three-portal VATS lobectomy for earl...

(This article belongs to the Section Respiratory Medicine)
  • Article
  • Open Access
4,368 Views
10 Pages

Intra-Observer and Inter-Observer Reliability of Ankle Circumference Measurement in Patients with Diabetic Foot: A Prospective Observational Study

  • David Montoro-Cremades,
  • Aroa Tardáguila-García,
  • David Navarro-Pérez,
  • Yolanda García-Álvarez,
  • Mateo López-Moral and
  • José Luis Lázaro-Martínez

18 November 2023

Inflammation, being a typical response to vascular tissue alterations, induces variations in tissue oxygen diffusion pressure. Diabetic microangiopathy, an inflammatory process, is characterized by an increase in vascular flow at rest, reduced venous...

(This article belongs to the Section Endocrinology & Metabolism)
  • Article
  • Open Access
12 Citations
4,210 Views
10 Pages

Biomarkers for Monitoring of Changes in Disease Activity in Ulcerative Colitis

  • Yoshihiro Tatsumi,
  • Kazuki Kakimoto,
  • Azusa Hara,
  • Noboru Mizuta,
  • Keijiro Numa,
  • Naohiko Kinoshita,
  • Kei Nakazawa,
  • Ryoji Koshiba,
  • Yuki Hirata and
  • Hiroki Nishikawa
  • + 6 authors

18 November 2023

Background: In recent years, various biomarkers of ulcerative colitis (UC) have emerged; however, few studies have simultaneously examined the utility of multiple biomarkers for monitoring disease activity. Additionally, serum leucine-rich alpha-2 gl...

(This article belongs to the Special Issue Inflammatory Bowel Disease: From Diagnosis to Treatment)
  • Article
  • Open Access
4 Citations
2,555 Views
14 Pages

Multivariable Risk Modelling and Survival Analysis with Machine Learning in SARS-CoV-2 Infection

  • Andrea Ciarmiello,
  • Francesca Tutino,
  • Elisabetta Giovannini,
  • Amalia Milano,
  • Matteo Barattini,
  • Nikola Yosifov,
  • Debora Calvi,
  • Maurizo Setti,
  • Massimiliano Sivori and
  • Giampiero Giovacchini
  • + 5 authors

18 November 2023

Aim: To evaluate the performance of a machine learning model based on demographic variables, blood tests, pre-existing comorbidities, and computed tomography(CT)-based radiomic features to predict critical outcome in patients with acute respiratory s...

(This article belongs to the Section Infectious Diseases)
  • Article
  • Open Access
13 Citations
2,734 Views
10 Pages

Musculoskeletal Rehabilitation: New Perspectives in Postoperative Care Following Total Knee Arthroplasty Using an External Motion Sensor and a Smartphone Application for Remote Monitoring

  • Mirjam Victoria Neumann-Langen,
  • Björn Gunnar Ochs,
  • Jörg Lützner,
  • Anne Postler,
  • Julia Kirschberg,
  • Khosrow Sehat,
  • Marius Selig and
  • Thomas M. Grupp

18 November 2023

Background: The number of total knee replacements performed annually is steadily increasing. Parallel options for postoperative care are decreasing, which reduces patient satisfaction. External devices to support physical rehabilitation and health mo...

(This article belongs to the Special Issue Musculoskeletal Rehabilitation: Current Challenges and New Perspectives)
  • Article
  • Open Access
4 Citations
2,954 Views
14 Pages

Expression of miRNAs in Pre-Schoolers with Autism Spectrum Disorders Compared with Typically Developing Peers and Its Effects after Probiotic Supplementation

  • Letizia Guiducci,
  • Manuela Cabiati,
  • Elisa Santocchi,
  • Margherita Prosperi,
  • Maria Aurora Morales,
  • Filippo Muratori,
  • Emioli Randazzo,
  • Giovanni Federico,
  • Sara Calderoni and
  • Silvia Del Ry

18 November 2023

Alteration of the microbiota–gut–brain axis has been recently recognized as a possible contributor to the physiopathology of autism spectrum disorder (ASD). In this context, microRNA (miRNAs) dysfunction, implicated both in several neurop...

(This article belongs to the Special Issue Advances in Autism Spectrum Disorder: Etiopathogenesis, Clinical Phenotypes, Diagnosis and Treatment)
  • Article
  • Open Access
13 Citations
3,089 Views
12 Pages

Male and Female Discrepancies in Anxiety, Depressive Symptoms, and Coping Strategies among Orthognathic Patients: A Cross-Sectional Analysis

  • Robert Avramut,
  • Serban Talpos,
  • Camelia Szuhanek,
  • Marius Pricop,
  • Roxana Talpos,
  • Tareq Hajaj,
  • Nicoleta Nikolajevic-Stoican,
  • Raluca Maracineanu,
  • Roxana Ghircau-Radu and
  • Malina Popa

18 November 2023

With an increasing understanding of the differences between men and women’s psychological experiences, this study aimed to probe the sex-based differences in anxiety, depressive symptoms, and coping strategies among orthognathic patients. The s...

(This article belongs to the Special Issue Orthodontics: Current Clinical Status and Future Challenges)
  • Article
  • Open Access
5 Citations
2,978 Views
13 Pages

Women with Metabolic Syndrome and Unhealthy Lifestyle Factors Are at a Higher Risk for Hyperuricemia

  • Seonyoung Kang,
  • Kyungdo Han,
  • Jinhyoung Jung,
  • Yeonghee Eun,
  • In Young Kim,
  • Eun-Mi Koh,
  • Seulkee Lee,
  • Hoon-Suk Cha,
  • Hyungjin Kim and
  • Jaejoon Lee

18 November 2023

Hyperuricemia (HUA) has become a significant medical concern due to its complications and links to metabolic syndrome (MetS) and cardiovascular disease (CVD), which result in increased mortality. The pathogenic processes associated with unhealthy beh...

(This article belongs to the Section Endocrinology & Metabolism)
  • Article
  • Open Access
10 Citations
2,783 Views
9 Pages

Self-Reported Physical Inactivity and Mood Disturbances in End-Stage Kidney Disease (ESKD) Patients on Chronic Dialysis Treatment

  • Michela Musolino,
  • Pierangela Presta,
  • Paola Cianfrone,
  • Maria Antonietta Errante,
  • Michele Andreucci,
  • Giuseppe Coppolino and
  • Davide Bolignano

18 November 2023

Background: Physical inactivity and mood disturbances are key issues in individuals with end-stage kidney disease (ESKD) and may lead to poor clinical outcomes. Methods: We performed a pilot, observational study to explore the possible relationships...

(This article belongs to the Special Issue New Insights into Peritoneal Dialysis and Hemodialysis)
  • Article
  • Open Access
3 Citations
4,672 Views
15 Pages

The Influence of Rheumatoid Arthritis and Osteoarthritis on the Occurrence of Arterial Hypertension: An 8-Year Prospective Clinical Observational Cohort Study

  • Dražen Bedeković,
  • Damir Kirner,
  • Ivica Bošnjak,
  • Aleksandar Kibel,
  • Sandra Šarić,
  • Srđan Novak and
  • Višnja Prus

18 November 2023

Rheumatoid arthritis (RA) increases the risk of cardiovascular mortality and morbidity, including a 50–60% increased risk of cardiovascular disease (CVD). Arterial hypertension (HT) is considered the major contributing risk factor for CVD devel...

(This article belongs to the Special Issue Targeted Treatment in Rheumatoid Arthritis)
  • Article
  • Open Access
1 Citations
2,801 Views
12 Pages

A Quick and Practical Approach to Secure a Chronic Fatigue Syndrome Diagnosis: The Novel Functional Limitation Index

  • Juan Antonio Corbalán,
  • Gisela Feltes,
  • Daniela Silva,
  • Eduardo Gómez-Utrero and
  • Iván J. Núñez-Gil

17 November 2023

Chronic Fatigue Syndrome (CFS) is a serious, clinical, long-term condition with an unclear etiology and a difficult diagnosis. Our aim is to propose an objective physiological parameter (Functional Limitation Index, FLI) that describes the degree of...

(This article belongs to the Section Clinical Neurology)
  • Article
  • Open Access
25 Citations
5,409 Views
16 Pages

Development and Validation of Deep-Learning-Based Sepsis and Septic Shock Early Prediction System (DeepSEPS) Using Real-World ICU Data

  • Taehwa Kim,
  • Yunwon Tae,
  • Hye Ju Yeo,
  • Jin Ho Jang,
  • Kyungjae Cho,
  • Dongjoon Yoo,
  • Yeha Lee,
  • Sung-Ho Ahn,
  • Younga Kim and
  • Woo Hyun Cho
  • + 1 author

17 November 2023

Background: Successful sepsis treatment depends on early diagnosis. We aimed to develop and validate a system to predict sepsis and septic shock in real time using deep learning. Methods: Clinical data were retrospectively collected from electronic m...

(This article belongs to the Special Issue Advancing Clinical Medicine through Artificial Intelligence (AI) and Digital Technology)
  • Systematic Review
  • Open Access
8 Citations
4,489 Views
13 Pages

The Efficacy and Safety of Rebamipide Ophthalmic Suspension (OPC-12759) in Patients with Dry Eye Disease: A Systematic Review of Randomized Controlled Trials

  • Antonio Ballesteros-Sánchez,
  • María Carmen Sánchez-González,
  • Concepción De-Hita-Cantalejo,
  • Estanislao Gutiérrez-Sánchez,
  • Carlos Rocha-de-Lossada and
  • José-María Sánchez-González

17 November 2023

The aim of this paper is to evaluate the efficacy and safety of Rebamipide (REB) ophthalmic suspension in dry eye disease (DED). A systematic review that only included full-length randomized controlled studies (RCTs) reporting the effects of REB opht...

(This article belongs to the Special Issue Advances in Dry Eye Disease Treatment)
  • Systematic Review
  • Open Access
6 Citations
4,032 Views
38 Pages

17 November 2023

Background: The use of inert gas rebreathing for the non-invasive cardiac output measurement has produced measurements comparable to those obtained by various other methods. However, there are no guidelines for the inert gas rebreathing method during...

(This article belongs to the Special Issue (Cardio-)Vascular System in Health and Disease: Current Update and Perspectives—Volume II)
  • Article
  • Open Access
6 Citations
2,915 Views
19 Pages

17 November 2023

Background: Mood disorders, especially depression, and emotional difficulties such as anxiety are very common problems among patients with spinal cord injuries (SCIs). The lack of physical training may deteriorate their mental state, which, in turn,...

(This article belongs to the Special Issue Spinal Cord Injuries: Advances in Rehabilitation)
  • Review
  • Open Access
23 Citations
4,889 Views
16 Pages

Perioperative Right Ventricular Dysfunction and Abnormalities of the Tricuspid Valve Apparatus in Patients Undergoing Cardiac Surgery

  • Alessia Mattei,
  • Alessandro Strumia,
  • Maria Benedetto,
  • Antonio Nenna,
  • Lorenzo Schiavoni,
  • Raffaele Barbato,
  • Ciro Mastroianni,
  • Omar Giacinto,
  • Mario Lusini and
  • Massimiliano Carassiti
  • + 1 author

17 November 2023

Right ventricular (RV) dysfunction frequently occurs after cardiac surgery and is linked to adverse postoperative outcomes, including mortality, reintubation, stroke, and prolonged ICU stays. While various criteria using echocardiography and hemodyna...

(This article belongs to the Special Issue Mitral and Tricuspid Valve Disease and Imaging Techniques)
  • Feature Paper
  • Article
  • Open Access
6 Citations
3,704 Views
17 Pages

Biologic Treatment Modification Efficacy in Concurrent Inflammatory Bowel Disease and Ankylosing Spondylitis: A Retrospective Cohort Study at a Single Tertiary Center

  • Einat Savin,
  • Niv Ben-Shabat,
  • Asaf Levartovsky,
  • Adi Lahat,
  • Mahmud Omar,
  • Omer Gendelman,
  • Merav Lidar,
  • Abdulla Watad,
  • Shomron Ben-Horin and
  • Kassem Sharif
  • + 1 author

17 November 2023

Background: The link between ankylosing spondylitis (AS) and inflammatory bowel disease (IBD) is well-established, with concurrent prevalence estimates ranging from 5–10%. However, there are still significant gaps in our understanding, and a comprehe...

(This article belongs to the Section Immunology & Rheumatology)
  • Communication
  • Open Access
1,933 Views
10 Pages

Novel Genetic Microvascular Dysplasia Causing Hypoperfusion of Cardiac, Renal, and Cerebral Circulation

  • Andrea Frustaci,
  • Rosario Cianci,
  • Romina Verardo,
  • Bruna Cerbelli,
  • Maria Cecilia D’Asdia and
  • Alessandro De Luca

17 November 2023

Background: Microvascular disorders represent an uncommon site of tissue hypo-perfusion and damage. Various genetic and acquired causes can be involved. A 65-year-old man was admitted because of refractory angina, which he had had since the age of 30...

(This article belongs to the Special Issue Cardiomyopathy: Clinical Diagnosis and Treatment: Part II)
  • Article
  • Open Access
3 Citations
4,697 Views
12 Pages

17 November 2023

In patients with right heart failure (RHF) and pulmonary hypertension (PH), classical teaching often advises cautious diuresis in the setting of ‘preload dependence’ to avoid renal injury and hemodynamic compromise. However, while this ph...

(This article belongs to the Special Issue Pulmonary Hypertension: Updates in Diagnosis and Management)
  • Article
  • Open Access
4 Citations
2,978 Views
8 Pages

17 November 2023

Purpose: Acquired defects of the central face pose significant challenges in achieving acceptable cosmetic and functional outcomes. The site, size, and depth of tissue loss often render local tissues inadequate for the repair of major nasal defects....

(This article belongs to the Section Otolaryngology)
  • Systematic Review
  • Open Access
8 Citations
3,092 Views
10 Pages

17 November 2023

Goals: To assess the characteristics and prognosis-influencing factors of phlegmonous esophagitis, a rare condition marked by suppurative inflammation of the esophageal submucosa and muscular layers. Background: Effective management strategies for ph...

(This article belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

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J. Clin. Med. - ISSN 2077-0383