Comparison of Fluid Replacement with Sterofundin ISO® vs. Deltajonin® in Infants Undergoing Craniofacial Surgery—A Retrospective Study
Round 1
Reviewer 1 Report
This article is interesting, but here are some comments.
1. In the abstract and materials and methods sections, the research design is not clearly explained. It is recommended to refine these sections, particularly in terms of describing the research design, specifying patient age, outlining inclusion and exclusion criteria, and so on.
2. In line 160-168, although there is no significant difference, it would be better if this section were also displayed in table form.
3. In lines 188-189, the administration of catecholamine support is not included in the existing table. As a suggestion, this information can be added into Table 2, with an additional titled ‘administration of Catecholamine Support’ alongside the original title ‘intraoperative fluid administration’.
4. In lines 159, 229, 316, 341, The frequent use of the phrase 'in conclusion' throughout the article is excessive. Please include this word only at the end of the discussion.
Author Response
See attachment.
Author Response File: 
Author Response.docx
Reviewer 2 Report
Thank you for permitting me to review this manuscript
In this manuscript the authors compared retrospectively two regimens of fluid therapy in craniofacial surgery for children and found that crystalloids such as sterofundin , might induce hyperchloremic acidosis
Line 301 , please describe SIG (may be I missed it before)
Here are my suggestions
Line 48 please precise which country ? I guess Germany?
PLease escribe and elaborate earlier in the introduction the hyperchloremic state and its negative impact
Line 115 , why the target of hb transfusion in 10 ? please explain
as this target is lower elsewhere
Please elaborate the sample size calculation simply setting 50 is not enough
Since there was difference in the two groups within the cohort a matching with propension score would have been useful please explain why no matching was used
figure 1 and 2 the asterisk is bettter to be for sterofundin
Author Response
See attachment.
Author Response File: Author Response.docx
Round 2
Reviewer 2 Report
The authors have responded to my queries
Author Response
Please see attached file
Author Response File: 
Author Response.pdf
