MRI-Based Quantification of Pan-Alimentary Function and Motility in Subjects with Diabetes and Gastrointestinal Symptoms
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Subject Selection
2.2. Study Design
2.3. Questionnaire Data
2.4. Image Acquisition
2.5. MRI
2.6. Quality Assessment
2.7. Image Processing
2.8. Patient Classification Using Machine Learning
2.9. Statistical Analysis
3. Results
3.1. Demography
3.2. Questionnaires
3.2.1. Symptoms Assessed at Baseline
3.2.2. Symptom Scores in Response to a Test Meal
3.3. Gastric Volumes Distribution and Compartmental Analysis
3.4. Gastric Motility and Emptying
3.5. Small Bowel Volume and Motility
3.6. Colonic Volume and Motility
3.7. Colonic Water Content
3.8. Association between Symptoms Scores and Multi-Segmental MRI Measures
3.9. Elastic Net Regression and Linear Discriminant Analysis
4. Discussion
4.1. Overview of Findings and Comparison with Recent Literature
4.1.1. Stomach
4.1.2. Small Bowel
4.1.3. Colon
4.2. Limitations and Future Perspectives
4.3. New Directions
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Patients with DM and GI Symptoms (n = 46) | Healthy (n = 40) | |
---|---|---|
Age (years) | 62 ± 12 | 57 ± 10 |
Gender (M/F) | 28:18 | 27:13 |
BMI * (kg/m2) | 30 ± 6 | 27 ± 5 |
Smokers (%) | 9.5 (n = 4) | 8.1 (n = 3) |
Mean systolic pressure (mmHg) | 134 ± 15 | 141 ± 21 |
Mean diastolic pressure * | 78 ± 9 | 85 ± 11 |
Diabetes (type1/type2) | 9:36 | - |
Diabetes duration (years) | 20 ± 14 | - |
Charlson Comorbidity index | 1.8 ± 1.0 | - |
Questionnaires-GCSI | ||
Nausea score * | 0.7 ± 0.8 | 0 ± 0 |
Satiety score * | 1.5 ± 0.9 | 0.3 ± 0.5 |
Bloating score * | 1.9 ± 1.5 | 0.3 ± 0.6 |
Total GCSI score * | 1.4 ± 0.9 | 0.3 ± 0.4 |
Questionnaires-GSRS | ||
Reflux score * | 2.1 ± 1.0 | 1.3 ± 0.6 |
Abdominal pain score * | 2.5 ± 1.0 | 1.1 ± 0.2 |
Indigestion score * | 3.2 ± 1.4 | 1.3 ± 0.4 |
Diarrhea score * | 3.0 ± 1.6 | 1.1 ± 0.3 |
Constipation score * | 3.3 ± 1.4 | 1.1 ± 0.2 |
Total GSRS score * | 2.8 ± 0.8 | 1.2 ± 0.2 |
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Bertoli, D.; Mark, E.B.; Liao, D.; Okdahl, T.; Nauser, S.; Daugberg, L.H.; Brock, C.; Brock, B.; Knop, F.K.; Krogh, K.; et al. MRI-Based Quantification of Pan-Alimentary Function and Motility in Subjects with Diabetes and Gastrointestinal Symptoms. J. Clin. Med. 2023, 12, 5968. https://doi.org/10.3390/jcm12185968
Bertoli D, Mark EB, Liao D, Okdahl T, Nauser S, Daugberg LH, Brock C, Brock B, Knop FK, Krogh K, et al. MRI-Based Quantification of Pan-Alimentary Function and Motility in Subjects with Diabetes and Gastrointestinal Symptoms. Journal of Clinical Medicine. 2023; 12(18):5968. https://doi.org/10.3390/jcm12185968
Chicago/Turabian StyleBertoli, Davide, Esben Bolvig Mark, Donghua Liao, Tina Okdahl, Serena Nauser, Louise Hostrup Daugberg, Christina Brock, Birgitte Brock, Filip Krag Knop, Klaus Krogh, and et al. 2023. "MRI-Based Quantification of Pan-Alimentary Function and Motility in Subjects with Diabetes and Gastrointestinal Symptoms" Journal of Clinical Medicine 12, no. 18: 5968. https://doi.org/10.3390/jcm12185968