Depressive Symptoms in Patients with Fibromyalgia: Current Evidence and Preventive Approaches
1. Medications: Antidepressants
2. Lifestyle Change: Exercise
3. Nutrient Supplement: Vitamin D
4. Psychological Interventions
Author Contributions
Funding
Data Availability Statement
Conflicts of Interest
References
- Munoz Ladron de Guevara, C.; Reyes Del Paso, G.A.; Fernandez Serrano, M.J.; Montoro, C.I. Fibromyalgia Syndrome and Cognitive Decline: The Role of Body Mass Index and Clinical Symptoms. J. Clin. Med. 2022, 11, 3404. [Google Scholar] [CrossRef] [PubMed]
- Hauser, W.; Ablin, J.; Fitzcharles, M.A.; Littlejohn, G.; Luciano, J.V.; Usui, C.; Walitt, B. Fibromyalgia. Nat. Rev. Dis. Prim. 2015, 1, 15022. [Google Scholar] [PubMed]
- Gau, S.Y.; Lee, Y.H.; Tsou, H.K.; Huang, J.Y.; Chen, X.; Ye, Z.; Wei, J.C. Patients with Ankylosing Spondylitis Are Associated with High Risk of Fibromyalgia: A Nationwide Population-Based Cohort Study. Front. Med. 2021, 8, 618594. [Google Scholar] [CrossRef] [PubMed]
- Gau, S.Y.; Leong, P.Y.; Lin, C.L.; Tsou, H.K.; Wei, J.C. Higher Risk for Sjogren’s Syndrome in Patients With Fibromyalgia: A Nationwide Population-Based Cohort Study. Front. Immunol. 2021, 12, 640618. [Google Scholar] [CrossRef] [PubMed]
- Garrido-Ardila, E.M.; Gonzalez-Lopez-Arza, M.V.; Jimenez-Palomares, M.; Garcia-Nogales, A.; Rodriguez-Mansilla, J. Effects of Physiotherapy vs. Acupuncture in Quality of Life, Pain, Stiffness, Difficulty to Work and Depression of Women with Fibromyalgia: A Randomized Controlled Trial. J. Clin. Med. 2021, 10, 3765. [Google Scholar] [CrossRef]
- Mory, L.N.; de Oliveira Fernandes, D.; Mancini, C.; Mouthon, M.; Chabwine, J.N. The Affective Dimension of Pain Appears to Be Determinant within a Pain-Insomnia-Anxiety Pathological Loop in Fibromyalgia: A Case-Control Study. J. Clin. Med. 2022, 11, 3296. [Google Scholar] [CrossRef]
- Mucci, V.; Demori, I.; Rapallo, F.; Molinari, E.; Losacco, S.; Marinelli, L.; Browne, C.J.; Burlando, B. Vestibular Disability/Handicap in Fibromyalgia: A Questionnaire Study. J. Clin. Med. 2022, 11, 4017. [Google Scholar] [CrossRef] [PubMed]
- Alciati, A.; Atzeni, F.; Caldirola, D.; Perna, G.; Sarzi-Puttini, P. The Co-Morbidity between Bipolar and Panic Disorder in Fibromyalgia Syndrome. J. Clin. Med. 2020, 9, 3619. [Google Scholar] [CrossRef]
- Carta, M.G.; Moro, M.F.; Pinna, F.L.; Testa, G.; Cacace, E.; Ruggiero, V.; Piras, M.; Romano, F.; Minerba, L.; Machado, S.; et al. The impact of fibromyalgia syndrome and the role of comorbidity with mood and post-traumatic stress disorder in worsening the quality of life. Int. J. Soc. Psychiatry 2018, 64, 647–655. [Google Scholar] [CrossRef]
- Loge-Hagen, J.S.; Saele, A.; Juhl, C.; Bech, P.; Stenager, E.; Mellentin, A.I. Prevalence of depressive disorder among patients with fibromyalgia: Systematic review and meta-analysis. J. Affect Disord. 2019, 245, 1098–1105. [Google Scholar] [CrossRef]
- Zhao, S.S.; Holmes, M.V.; Alam, U. Disentangling the relationship between depression and chronic widespread pain: A Mendelian randomisation study. Semin. Arthritis Rheum. 2023, 60, 152188. [Google Scholar] [CrossRef]
- Arnold, L.M.; Fan, J.; Russell, I.J.; Yunus, M.B.; Khan, M.A.; Kushner, I.; Olson, J.M.; Iyengar, S.K. The fibromyalgia family study: A genome-wide linkage scan study. Arthritis Rheum. 2013, 65, 1122–1128. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Janssen, L.P.; Medeiros, L.F.; Souza, A.D.; Silva, J.D. Fibromyalgia: A Review of Related Polymorphisms and Clinical Relevance. An. Acad. Bras. Ciências 2021, 93 (Suppl. S4), e20210618. [Google Scholar] [CrossRef] [PubMed]
- Andres-Rodriguez, L.; Borras, X.; Feliu-Soler, A.; Perez-Aranda, A.; Angarita-Osorio, N.; Moreno-Peral, P.; Montero-Marin, J.; Garcia-Campayo, J.; Carvalho, A.F.; Maes, M.; et al. Peripheral immune aberrations in fibromyalgia: A systematic review, meta-analysis and meta-regression. Brain Behav. Immun. 2020, 87, 881–889. [Google Scholar] [CrossRef] [PubMed]
- Mendieta, D.; De la Cruz-Aguilera, D.L.; Barrera-Villalpando, M.I.; Becerril-Villanueva, E.; Arreola, R.; Hernandez-Ferreira, E.; Perez-Tapia, S.M.; Perez-Sanchez, G.; Garces-Alvarez, M.E.; Aguirre-Cruz, L.; et al. IL-8 and IL-6 primarily mediate the inflammatory response in fibromyalgia patients. J. Neuroimmunol. 2016, 290, 22–25. [Google Scholar] [CrossRef]
- Tsai, S.J. Role of interleukin 8 in depression and other psychiatric disorders. Prog. Neuropsychopharmacol. Biol. Psychiatry 2021, 106, 110173. [Google Scholar]
- Latremoliere, A.; Woolf, C.J. Central sensitization: A generator of pain hypersensitivity by central neural plasticity. J. Pain 2009, 10, 895–926. [Google Scholar] [CrossRef] [Green Version]
- Adams, L.M.; Turk, D.C. Psychosocial factors and central sensitivity syndromes. Curr. Rheumatol. Rev. 2015, 11, 96–108. [Google Scholar] [CrossRef] [Green Version]
- Gracely, R.H.; Geisser, M.E.; Giesecke, T.; Grant, M.A.; Petzke, F.; Williams, D.A.; Clauw, D.J. Pain catastrophizing and neural responses to pain among persons with fibromyalgia. Brain 2004, 127, 835–843. [Google Scholar] [CrossRef] [Green Version]
- Siracusa, R.; Paola, R.D.; Cuzzocrea, S.; Impellizzeri, D. Fibromyalgia: Pathogenesis, Mechanisms, Diagnosis and Treatment Options Update. Int. J. Mol. Sci. 2021, 22, 3891. [Google Scholar] [CrossRef]
- Suzuki, K.; Haruyama, Y.; Kobashi, G.; Sairenchi, T.; Uchiyama, K.; Yamaguchi, S.; Hirata, K. Central Sensitization in Neurological, Psychiatric, and Pain Disorders: A Multicenter Case-Controlled Study. Pain Res. Manag. 2021, 2021, 6656917. [Google Scholar] [CrossRef] [PubMed]
- McKernan, L.C.; Finn, M.T.M.; Carr, E.R. Personality and Affect When the Central Nervous System is Sensitized: An Analysis of Central Sensitization Syndromes in a Substance Use Disorder Population. Psychodyn. Psychiatry 2017, 45, 385–409. [Google Scholar] [CrossRef] [PubMed]
- Hung, C.H.; Lee, Y.H.; Wei, J.C. Amitriptyline for fibromyalgia: Off-label treatment, but non-inferior to approved medication. Int. J. Rheum. Dis. 2023, 26, 607–608. [Google Scholar] [CrossRef] [PubMed]
- Farag, H.M.; Yunusa, I.; Goswami, H.; Sultan, I.; Doucette, J.A.; Eguale, T. Comparison of Amitriptyline and US Food and Drug Administration-Approved Treatments for Fibromyalgia: A Systematic Review and Network Meta-analysis. JAMA Netw. Open 2022, 5, e2212939. [Google Scholar] [CrossRef]
- Bidonde, J.; Busch, A.J.; Schachter, C.L.; Overend, T.J.; Kim, S.Y.; Goes, S.M.; Boden, C.; Foulds, H.J. Aerobic exercise training for adults with fibromyalgia. Cochrane Database Syst. Rev. 2017, 6, CD012700. [Google Scholar] [CrossRef]
- Bidonde, J.; Busch, A.J.; Schachter, C.L.; Webber, S.C.; Musselman, K.E.; Overend, T.J.; Goes, S.M.; Dal Bello-Haas, V.; Boden, C. Mixed exercise training for adults with fibromyalgia. Cochrane Database Syst. Rev. 2019, 5, CD013340. [Google Scholar] [CrossRef] [PubMed]
- Bidonde, J.; Busch, A.J.; Webber, S.C.; Schachter, C.L.; Danyliw, A.; Overend, T.J.; Richards, R.S.; Rader, T. Aquatic exercise training for fibromyalgia. Cochrane Database Syst. Rev. 2014, 10, CD011336. [Google Scholar] [CrossRef]
- Kim, S.Y.; Busch, A.J.; Overend, T.J.; Schachter, C.L.; van der Spuy, I.; Boden, C.; Goes, S.M.; Foulds, H.J.; Bidonde, J. Flexibility exercise training for adults with fibromyalgia. Cochrane Database Syst. Rev. 2019, 9, CD013419. [Google Scholar] [CrossRef] [Green Version]
- Couto, N.; Monteiro, D.; Cid, L.; Bento, T. Effect of different types of exercise in adult subjects with fibromyalgia: A systematic review and meta-analysis of randomised clinical trials. Sci. Rep. 2022, 12, 10391. [Google Scholar] [CrossRef]
- McCabe, P.S.; Pye, S.R.; Beth, J.M.; Lee, D.M.; Tajar, A.; Bartfai, G.; Boonen, S.; Bouillon, R.; Casanueva, F.; Finn, J.D.; et al. Low vitamin D and the risk of developing chronic widespread pain: Results from the European male ageing study. BMC Musculoskelet. Disord. 2016, 17, 32. [Google Scholar] [CrossRef] [Green Version]
- Akar, N.; Sayiner Caglar, N.; Aytekin, E.; Akar, A.; Aksu, O.; Oz, N. Low levels of serum vitamin D3 are associated with fibromyalgia syndrome in pre-menopausal women: A pilot study. Turk. J. Phy.s Med. Rehabil. 2020, 66, 67–72. [Google Scholar] [CrossRef] [PubMed]
- Dogru, A.; Balkarli, A.; Cobankara, V.; Tunc, S.E.; Sahin, M. Effects of Vitamin D Therapy on Quality of Life in Patients with Fibromyalgia. Eurasian J. Med. 2017, 49, 113–117. [Google Scholar] [CrossRef] [PubMed]
- Mirzaei, A.; Zabihiyeganeh, M.; Jahed, S.A.; Khiabani, E.; Nojomi, M.; Ghaffari, S. Effects of vitamin D optimization on quality of life of patients with fibromyalgia: A randomized controlled trial. Med. J. Islam. Repub. Iran. 2018, 32, 29. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Yang, C.C.; Tsai, S.T.; Ting, B.; Cheng, Y.C.; Wang, C.K.; Chang, J.P.; Su, K.P. Psychological Outcomes and Quality of Life of Fibromyalgia Patients with Vitamin D Supplementation-A Meta-Analysis. J. Clin. Med. 2023, 12, 2750. [Google Scholar] [CrossRef]
- Prados, G.; Miro, E.; Martinez, M.P.; Sanchez, A.I.; Pichot, V.; Medina-Casado, M.; Chouchou, F. Effect of Cognitive-Behavioral Therapy on Nocturnal Autonomic Activity in Patients with Fibromyalgia: A Preliminary Study. Brain Sci. 2022, 12, 947. [Google Scholar] [CrossRef]
- Bernardy, K.; Klose, P.; Busch, A.J.; Choy, E.H.; Hauser, W. Cognitive behavioural therapies for fibromyalgia. Cochrane Database Syst. Rev. 2013, 2013, CD009796. [Google Scholar] [CrossRef]
- Aguilera, M.; Paz, C.; Salla, M.; Compan, V.; Medina, J.C.; Medeiros-Ferreira, L.; Feixas, G. Cognitive-Behavioral and Personal Construct Therapies for Depression in Women with Fibromyalgia: A Randomized Controlled Trial. Int. J. Clin. Health Psychol. 2022, 22, 100296. [Google Scholar] [CrossRef]
- Serrat, M.; Sanabria-Mazo, J.P.; Almirall, M.; Muste, M.; Feliu-Soler, A.; Mendez-Ulrich, J.L.; Sanz, A.; Luciano, J.V. Effectiveness of a Multicomponent Treatment Based on Pain Neuroscience Education, Therapeutic Exercise, Cognitive Behavioral Therapy, and Mindfulness in Patients With Fibromyalgia (FIBROWALK Study): A Randomized Controlled Trial. Phys. Ther. 2021, 101, pzab200. [Google Scholar] [CrossRef]
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Gau, S.-Y.; Hung, T.-H.; Chuang, M.-F.; Wei, J.C.-C. Depressive Symptoms in Patients with Fibromyalgia: Current Evidence and Preventive Approaches. J. Clin. Med. 2023, 12, 3987. https://doi.org/10.3390/jcm12123987
Gau S-Y, Hung T-H, Chuang M-F, Wei JC-C. Depressive Symptoms in Patients with Fibromyalgia: Current Evidence and Preventive Approaches. Journal of Clinical Medicine. 2023; 12(12):3987. https://doi.org/10.3390/jcm12123987
Chicago/Turabian StyleGau, Shuo-Yan, Tsung-Hsuan Hung, Min-Fei Chuang, and James Cheng-Chung Wei. 2023. "Depressive Symptoms in Patients with Fibromyalgia: Current Evidence and Preventive Approaches" Journal of Clinical Medicine 12, no. 12: 3987. https://doi.org/10.3390/jcm12123987
APA StyleGau, S.-Y., Hung, T.-H., Chuang, M.-F., & Wei, J. C.-C. (2023). Depressive Symptoms in Patients with Fibromyalgia: Current Evidence and Preventive Approaches. Journal of Clinical Medicine, 12(12), 3987. https://doi.org/10.3390/jcm12123987