Ethnicity, Race and Skin Color: Challenges and Opportunities for Atopic Dermatitis Clinical Trials
Abstract
:1. Reporting of Ethnicity, Race and Skin of Color in Clinical Trials
2. Diagnostic Challenges
3. Challenges in Measuring Treatment Efficacy
4. Challenges in Evaluating Treatment Safety
5. Challenges of Generating Information from Patient Populations where the Drug Is Intended to Be Used
6. Conclusions and Recommendations
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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AD in Lighter Skin Patients | AD in Darker Skin Patients |
---|---|
Mostly flexural involvement | Extensor involvement often present |
Psoriasiform morphology rarely present | Psoriasiform morphology often present (Asian patients) |
Inflamed skin appears red | Inflammation often translates into greyish or violaceous (purple) color |
Less lichenification | More lichenification |
Excoriations are easily visible | Excoriations are often less visible |
Xerosis is often less visible | Xerosis is usually more visible |
Dyschromia is usually less present | Dyschromia if often the predominant feature |
Prurigo nodularis is less frequent | Prurigo nodularis is more often present |
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Bissonnette, R.; Jankicevic, J.; Saint-Cyr Proulx, E.; Maari, C. Ethnicity, Race and Skin Color: Challenges and Opportunities for Atopic Dermatitis Clinical Trials. J. Clin. Med. 2023, 12, 3805. https://doi.org/10.3390/jcm12113805
Bissonnette R, Jankicevic J, Saint-Cyr Proulx E, Maari C. Ethnicity, Race and Skin Color: Challenges and Opportunities for Atopic Dermatitis Clinical Trials. Journal of Clinical Medicine. 2023; 12(11):3805. https://doi.org/10.3390/jcm12113805
Chicago/Turabian StyleBissonnette, Robert, Jasmina Jankicevic, Etienne Saint-Cyr Proulx, and Catherine Maari. 2023. "Ethnicity, Race and Skin Color: Challenges and Opportunities for Atopic Dermatitis Clinical Trials" Journal of Clinical Medicine 12, no. 11: 3805. https://doi.org/10.3390/jcm12113805