Pandemic Preparedness: The Importance of Adequate Immune Fitness
Abstract
:1. Introduction
2. Methods
3. Results
3.1. CLOFIT Study
3.2. COTEST Study
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Variable | Overall | Men | Women | p-Value |
---|---|---|---|---|
n (%) | 1415 (100%) | 503 (35.5%) | 912 (64.5%) | <0.001 * |
Age (year) | 45.0 (18.5) | 49.7 (18.4) | 42.4 (18.0) | <0.001 * |
Height (m) | 1.73 (0.09) | 1.80 (0.08) | 1.69 (0.07) | <0.001 * |
Weight (kg) | 79.3 (18.8) | 87.6 (17.4) | 74.8 (17.9) | <0.001 * |
BMI (kg/m2) | 26.4 (5.8) | 26.9 (5.3) | 26.2 (6.1) | <0.001 * |
Underlying disease (% yes) | 65.5 | 60.4 | 68.3 | 0.003 * |
Immune fitness (2019) | 7.1 (2.4) | 7.8 (2.3) | 6.8 (2.5) | <0.001 * |
Immune fitness (DL) | 7.1 (2.0) | 7.4 (1.8) | 6.9 (2.1) | <0.001 * |
Number of COVID-19 Symptoms | 2.7 (2.2) | 2.4 (2.1) | 2.8 (2.3) | 0.010 * |
Severity of COVID-19 Symptoms | 0.44 (0.5) | 0.38 (0.4) | 0.48 (0.5) | 0.001 * |
Variable | Tested Positive | Tested Negative | p-Value |
---|---|---|---|
n | 88 | 837 | <0.001 * |
Male/female (%) | 60.2/39.8 | 54.5/45.5 | 0.313 |
Age (year) | 46.3 (13.3) | 47.0 (14.5) | 0.697 |
BMI (kg/m2) | 26.1 (4.4) | 26.0 (4.3) | 0.848 |
Underlying diseases (% yes) | 58.0 | 54.1 | 0.502 |
Immune fitness (2019) | 8.1 (1.7) | 7.8 (2.0) | 0.466 |
Immune fitness (T) | 7.3 (1.7) | 7.5 (1.6) | 0.714 |
Number of COVID-19 symptoms | 5.2 (3.2) | 3.4 (3.0) | <0.001 * |
Severity of COVID-19 symptoms | 0.46 (0.4) | 0.29 (0.3) | <0.001 * |
Correlations with Immune Fitness (2019) | |||||||
---|---|---|---|---|---|---|---|
Correlation with COVID-19 Symptoms | Overall | Tested Positive | Tested Negative | Comparison | |||
r | p-Value | r | p-Value | r | p-Value | p-Value | |
Number of symptoms | −0.431 | <0.001 * | −0.461 | <0.001 * | −0.442 | <0.001 * | 0.834 |
Severity of symptoms | −0.432 | <0.001 * | −0.482 | <0.001 * | −0.440 | <0.001 * | 0.638 |
Correlations with immune fitness (T) | |||||||
Number of symptoms | −0.451 | <0.001 * | −0.278 | 0.011 * | −0.473 | <0.001 * | 0.044 * |
Severity of symptoms | −0.459 | <0.001 * | −0.262 | 0.017 * | −0.481 | <0.001 * | 0.024 * |
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Kiani, P.; Balikji, J.; Kraneveld, A.D.; Garssen, J.; Bruce, G.; Verster, J.C. Pandemic Preparedness: The Importance of Adequate Immune Fitness. J. Clin. Med. 2022, 11, 2442. https://doi.org/10.3390/jcm11092442
Kiani P, Balikji J, Kraneveld AD, Garssen J, Bruce G, Verster JC. Pandemic Preparedness: The Importance of Adequate Immune Fitness. Journal of Clinical Medicine. 2022; 11(9):2442. https://doi.org/10.3390/jcm11092442
Chicago/Turabian StyleKiani, Pantea, Jessica Balikji, Aletta D. Kraneveld, Johan Garssen, Gillian Bruce, and Joris C. Verster. 2022. "Pandemic Preparedness: The Importance of Adequate Immune Fitness" Journal of Clinical Medicine 11, no. 9: 2442. https://doi.org/10.3390/jcm11092442
APA StyleKiani, P., Balikji, J., Kraneveld, A. D., Garssen, J., Bruce, G., & Verster, J. C. (2022). Pandemic Preparedness: The Importance of Adequate Immune Fitness. Journal of Clinical Medicine, 11(9), 2442. https://doi.org/10.3390/jcm11092442