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Background:
Review

Prevalence of Opioid Use Disorder among Patients with Cancer-Related Pain: A Systematic Review

by
Céline Preux
1,
Marion Bertin
1,
Andréa Tarot
1,
Nicolas Authier
2,3,4,
Nathalie Pinol
5,
David Brugnon
1,
Bruno Pereira
6 and
Virginie Guastella
1,2,*
1
Palliative Care Center, CHU Clermont-Ferrand, F-63000 Clermont-Ferrand, France
2
Neuro-Dol, Service Pharmacologie Médicale, Centres d’Addictovigilance et Pharmacovigilance, Centre Evaluation et Traitement de la Douleur, Inserm, CHU Clermont-Ferrand, Université de Clermont Auvergne, F-63001 Clermont-Ferrand, France
3
Institut Analgésia, Faculté de Médecine, BP38, F-63001 Clermont-Ferrand, France
4
Observatoire Français des Médicaments Antalgiques/French Monitoring Centre for Analgesic Drugs, Université Clermont-Ferrand, F-63001 Clermont-Ferrand, France
5
Centre de Documentation et Recherche de la Faculté de Médecine, CHU Clermont-Ferrand, Université de Clermont Auvergne, F-63000 Clermont-Ferrand, France
6
Unité de Biostatistiques, Direction de la Recherche Clinique et de l’Innovation, CHU Clermont-Ferrand, F-63000 Clermont-Ferrand, France
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2022, 11(6), 1594; https://doi.org/10.3390/jcm11061594
Submission received: 26 January 2022 / Revised: 3 March 2022 / Accepted: 10 March 2022 / Published: 14 March 2022
(This article belongs to the Section Anesthesiology)
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Abstract

Background: The opioid use disorder is an international public health problem. Over the past 20 years it has been the subject of numerous publications concerning patients treated for chronic pain other than cancer-related. Patients with cancer-related pain are also at risk of opioid use disorder. The primary objective of this literature review was to determine the prevalence of opioid use disorder in patients with cancer-related chronic pain. Its secondary objective was to identify the characteristics of these opioid users. Methods: This is a literature review of studies published over the last twenty years, from 1 January 2000 to 31 December 2020 identified by searching the three main medical databases: Pubmed, Cochrane, and Embase. A meta-analysis took account of between and within-study variability with the use of random-effects models estimated by the DerSimonian and Laird method. Results: The prevalence of opioid use disorder was 8% (1–20%) and of the risk of use disorder was 23.5% (19.5–27.8%) with I2 values of 97.8% and 88.7%, respectively. Conclusions: Further studies are now needed on the prevalence of opioid use disorder in patients treated for cancer-related chronic pain. A screening scale adapted to this patient population is urgently needed.
Keywords: meta-analysis; systematic review; prevalence; opioid use disorder; cancer; chronic pain meta-analysis; systematic review; prevalence; opioid use disorder; cancer; chronic pain

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MDPI and ACS Style

Preux, C.; Bertin, M.; Tarot, A.; Authier, N.; Pinol, N.; Brugnon, D.; Pereira, B.; Guastella, V. Prevalence of Opioid Use Disorder among Patients with Cancer-Related Pain: A Systematic Review. J. Clin. Med. 2022, 11, 1594. https://doi.org/10.3390/jcm11061594

AMA Style

Preux C, Bertin M, Tarot A, Authier N, Pinol N, Brugnon D, Pereira B, Guastella V. Prevalence of Opioid Use Disorder among Patients with Cancer-Related Pain: A Systematic Review. Journal of Clinical Medicine. 2022; 11(6):1594. https://doi.org/10.3390/jcm11061594

Chicago/Turabian Style

Preux, Céline, Marion Bertin, Andréa Tarot, Nicolas Authier, Nathalie Pinol, David Brugnon, Bruno Pereira, and Virginie Guastella. 2022. "Prevalence of Opioid Use Disorder among Patients with Cancer-Related Pain: A Systematic Review" Journal of Clinical Medicine 11, no. 6: 1594. https://doi.org/10.3390/jcm11061594

APA Style

Preux, C., Bertin, M., Tarot, A., Authier, N., Pinol, N., Brugnon, D., Pereira, B., & Guastella, V. (2022). Prevalence of Opioid Use Disorder among Patients with Cancer-Related Pain: A Systematic Review. Journal of Clinical Medicine, 11(6), 1594. https://doi.org/10.3390/jcm11061594

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