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Article

Adverse Events Associated with BNT162b2 and AZD1222 Vaccines in the Real World: Surveillance Report in a Single Italian Vaccine Center

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Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, 84081 Baronissi, Italy
2
Clinical Pharmacology Unit, University Hospital “San Giovanni di Dio e Ruggi d’Aragona”, 84121 Salerno, Italy
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Department of Medicine and Health Sciences, University of Molise, 86100 Campobasso, Italy
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Italian Society of Gerontology and Geriatrics (SIGG), 50122 Florence, Italy
5
DIIn, University of Salerno, 84084 Fisciano, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Antonio Muro
J. Clin. Med. 2022, 11(5), 1408; https://doi.org/10.3390/jcm11051408
Received: 2 February 2022 / Revised: 23 February 2022 / Accepted: 2 March 2022 / Published: 4 March 2022
Aim: Despite huge efforts in developing specific drugs, vaccination represents the only effective strategy against COVID-19. Efficacy and safety of the COVID-19 vaccines were established during clinical trials. Nonetheless, it is very important to perform continuous surveillance. This observational study aimed to report potential Adverse Events Following Immunization (AEFI) following the first dose of two different COVID-19 vaccines, BNT162b2 and AZD1222. Methods and Results: Subjects who underwent vaccination at the vaccine center of the University Hospital of Salerno, Italy, were interviewed using an ad hoc questionnaire. AZD-vac group (n = 175) who received AZD1222 had a higher number of AEFI than the BNT-vac group (n = 1613) who received BNT162b2 (83% vs. 42%). The most frequent AEFI associated with AZD1222 and BNT162b2 were fever and pain at the injection site, respectively. The AZD-vac group used drugs to contrast AEFI more frequently than the BNT-vac group. In the BNT-vac group, there was a higher incidence of AEFI in women than in men (26.2% vs. 15.8%, p = 0.01), while no gender-related difference was observed in the AZD-vac group. Conclusions: AZD1222 and BNT162b2 vaccines show a good safety profile. Based on our results and literature data, there are no reasons to justify the reluctance that persists towards immunization. View Full-Text
Keywords: COVID-19; vaccine; AEFI; BNT162b2; AZD1222; immunization COVID-19; vaccine; AEFI; BNT162b2; AZD1222; immunization
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MDPI and ACS Style

Costantino, M.; Sellitto, C.; Conti, V.; Corbi, G.; Marongiu, F.; Genovese, G.; Moccia, G.; Capunzo, M.; Borrelli, A.; Pagliano, P.; Farroni, M.; Lombardi, G.M.; Elberti, M.G.; Filippelli, A.; De Caro, F. Adverse Events Associated with BNT162b2 and AZD1222 Vaccines in the Real World: Surveillance Report in a Single Italian Vaccine Center. J. Clin. Med. 2022, 11, 1408. https://doi.org/10.3390/jcm11051408

AMA Style

Costantino M, Sellitto C, Conti V, Corbi G, Marongiu F, Genovese G, Moccia G, Capunzo M, Borrelli A, Pagliano P, Farroni M, Lombardi GM, Elberti MG, Filippelli A, De Caro F. Adverse Events Associated with BNT162b2 and AZD1222 Vaccines in the Real World: Surveillance Report in a Single Italian Vaccine Center. Journal of Clinical Medicine. 2022; 11(5):1408. https://doi.org/10.3390/jcm11051408

Chicago/Turabian Style

Costantino, Maria, Carmine Sellitto, Valeria Conti, Graziamaria Corbi, Francesco Marongiu, Giovanni Genovese, Giuseppina Moccia, Mario Capunzo, Anna Borrelli, Pasquale Pagliano, Mario Farroni, Grazia Maria Lombardi, Maria Giovanna Elberti, Amelia Filippelli, and Francesco De Caro. 2022. "Adverse Events Associated with BNT162b2 and AZD1222 Vaccines in the Real World: Surveillance Report in a Single Italian Vaccine Center" Journal of Clinical Medicine 11, no. 5: 1408. https://doi.org/10.3390/jcm11051408

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