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Article

Differences in Atrial Remodeling in Hypertrophic Cardiomyopathy Compared to Hypertensive Heart Disease and Athletes’ Hearts

1
Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland
2
CTU Bern, University of Bern, 3010 Bern, Switzerland
*
Author to whom correspondence should be addressed.
These authors have contributed equally to this work.
Academic Editor: Michele Correale
J. Clin. Med. 2022, 11(5), 1316; https://doi.org/10.3390/jcm11051316
Received: 1 February 2022 / Revised: 18 February 2022 / Accepted: 23 February 2022 / Published: 27 February 2022
(This article belongs to the Section Cardiology)
Background: Hypertrophic cardiomyopathy (HCM), hypertensive heart disease (HHD) and athletes’ heart share an increased prevalence of atrial fibrillation. Atrial cardiomyopathy in these patients may have different characteristics and help to distinguish these conditions. Methods: In this single-center study, we prospectively collected and analyzed electrocardiographic (12-lead ECG, signal-averaged ECG (SAECG), 24 h Holter ECG) and echocardiographic data in patients with HCM and HHD and in endurance athletes. Patients with atrial fibrillation were excluded. Results: We compared data of 27 patients with HCM (70% males, mean age 50 ± 14 years), 324 patients with HHD (52% males, mean age 75 ± 5.5 years), and 215 endurance athletes (72% males, mean age 42 ± 7.5 years). HCM patients had significantly longer filtered P-wave duration (153 ± 26 ms) and PR interval (191 ± 48 ms) compared to HHD patients (144 ± 16 ms, p = 0.012 and 178 ± 31, p = 0.034, respectively) and athletes (134 ± 14 ms, p = 0.001 and 165 ± 26 ms, both p < 0.001, respectively). HCM patients had a mean of 4.9 ± 16 premature atrial complexes per hour. Premature atrial complexes per hour were significantly more frequent in HHD patients (27 ± 86, p < 0.001), but not in athletes (2.7 ± 23, p = 0.639). Left atrial volume index (LAVI) was 43 ± 14 mL/m2 in HCM patients and significantly larger than age- and sex-corrected LAVI in HHD patients 30 ± 10 mL/m2; p < 0.001) and athletes (31 ± 9.5 mL/m2; p < 0.001). A borderline interventricular septum thickness ≥13 mm and ≤15 mm was found in 114 (35%) HHD patients, 12 (6%) athletes and 3 (11%) HCM patients. Conclusions: Structural and electrical atrial remodeling is more advanced in HCM patients compared to HHD patients and athletes. View Full-Text
Keywords: athlete’s heart; left ventricular hypertrophy; atrial cardiomyopathy; signal-averaged ECG; P-wave duration; LAVI athlete’s heart; left ventricular hypertrophy; atrial cardiomyopathy; signal-averaged ECG; P-wave duration; LAVI
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MDPI and ACS Style

Servatius, H.; Raab, S.; Asatryan, B.; Haeberlin, A.; Branca, M.; de Marchi, S.; Brugger, N.; Nozica, N.; Goulouti, E.; Elchinova, E.; Lam, A.; Seiler, J.; Noti, F.; Madaffari, A.; Tanner, H.; Baldinger, S.H.; Reichlin, T.; Wilhelm, M.; Roten, L. Differences in Atrial Remodeling in Hypertrophic Cardiomyopathy Compared to Hypertensive Heart Disease and Athletes’ Hearts. J. Clin. Med. 2022, 11, 1316. https://doi.org/10.3390/jcm11051316

AMA Style

Servatius H, Raab S, Asatryan B, Haeberlin A, Branca M, de Marchi S, Brugger N, Nozica N, Goulouti E, Elchinova E, Lam A, Seiler J, Noti F, Madaffari A, Tanner H, Baldinger SH, Reichlin T, Wilhelm M, Roten L. Differences in Atrial Remodeling in Hypertrophic Cardiomyopathy Compared to Hypertensive Heart Disease and Athletes’ Hearts. Journal of Clinical Medicine. 2022; 11(5):1316. https://doi.org/10.3390/jcm11051316

Chicago/Turabian Style

Servatius, Helge, Simon Raab, Babken Asatryan, Andreas Haeberlin, Mattia Branca, Stefano de Marchi, Nicolas Brugger, Nikolas Nozica, Eleni Goulouti, Elena Elchinova, Anna Lam, Jens Seiler, Fabian Noti, Antonio Madaffari, Hildegard Tanner, Samuel H. Baldinger, Tobias Reichlin, Matthias Wilhelm, and Laurent Roten. 2022. "Differences in Atrial Remodeling in Hypertrophic Cardiomyopathy Compared to Hypertensive Heart Disease and Athletes’ Hearts" Journal of Clinical Medicine 11, no. 5: 1316. https://doi.org/10.3390/jcm11051316

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