Neurologic Urinary Incontinence, Lower Urinary Tract Symptoms and Sexual Dysfunctions in Multiple Sclerosis: Expert Opinions Based on the Review of Current Evidences
Abstract
:1. Introduction
2. The Neurologist’s Role
3. The Urologist’s Role
4. The Gynecologist’s Role
5. Strengths and Limitations
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
- Compston, A.; Coles, A. Multiple sclerosis. Lancet 2002, 359, 1221–1231. [Google Scholar] [CrossRef]
- De Sèze, M.; Ruffion, A.; Denys, P.; Joseph, P.A.; Perrouin-Verbe, B. International Francophone Neuro-Urological expert study group (GENULF). The neurogenic bladder in multiple sclerosis: Review of the literature and proposal of management guidelines. Mult. Scler. J. 2007, 13, 915–928. [Google Scholar] [CrossRef] [PubMed]
- Phé, V.; Chartier–Kastler, E.; Panicker, J.N. Management of neurogenic bladder in patients with multiple sclerosis. Nat. Rev. Urol. 2016, 13, 275–288. [Google Scholar] [CrossRef] [PubMed]
- Mahajan, S.; Patel, P.; Marrie, R.A. Under Treatment of Overactive Bladder Symptoms in Patients with Multiple Sclerosis: An Ancillary Analysis of the NARCOMS Patient Registry. J. Urol. 2010, 183, 1432–1437. [Google Scholar] [CrossRef] [PubMed]
- Bientinesi, R.; Coluzzi, S.; Gavi, F.; Nociti, V.; Gandi, C.; Marino, F.; Moretto, S.; Mirabella, M.; Bassi, P.; Sacco, E. The Impact of Neurogenic Lower Urinary Tract Symptoms and Erectile Dysfunctions on Marital Relationship in Men with Multiple Sclerosis: A Single Cohort Study. J. Clin. Med. 2022, 11, 5639. [Google Scholar] [CrossRef] [PubMed]
- Fowler, C.J.; Panicker, J.N.; Drake, M.; Harris, C.; Harrison, S.C.W.; Kirby, M.; Lucas, M.; MacLeod, N.; Mangnall, J.; North, A.; et al. A UK consensus on the management of the bladder in multiple sclerosis. Postgrad. Med. J. 2009, 85, 552–559. [Google Scholar] [CrossRef]
- Thompson, A.J.; Baranzini, S.E.; Geurts, J.; Hemmer, B.; Ciccarelli, O. Multiple sclerosis. Lancet 2018, 391, 1622–1636. [Google Scholar] [CrossRef]
- Lublin, F.D.; Reingold, S.C.; Cohen, J.A.; Cutter, G.R.; Sørensen, P.S. Defining the clinical course of multiple sclerosis. Neurology 2014, 9, 907–911. [Google Scholar]
- Lemack, G.E.; Hawker, K.; Frohman, E. Incidence of upper tract abnormalities in patients with neurovesical dysfunction secondary to multiple sclerosis: Analysis of risk factors at initial urologic evaluation. Urology 2005, 65, 854–857. [Google Scholar] [CrossRef]
- Bientinesi, R.; Gandi, C.; Bassi, P. Managing Urological Disorders in Multiple Sclerosis Patients: A Review of Available and Emerging Therapies. Int. Neurourol. J. 2020, 24, 118–126. [Google Scholar] [CrossRef]
- De Ridder, D.; Van der Aa, F.; Debruyne, J.; D’hooghe, M.B.; Dubois, B.; Guillaume, D.; Heerings, M.; Ilsbroukx, S.; Medaer, R.; Nagels, G.; et al. Consensus guidelines on the neurologist’s role in the management of neurogenic lower urinary tract dysfunction in multiple sclerosis. Clin. Neurol. Neurosurg. 2013, 115, 2033–2040. [Google Scholar] [CrossRef] [PubMed]
- Averbeck, M.A.; Iacovelli, V.; Panicker, J.; Schurch, B.; Agrò, E.F. Urodynamics in patients with multiple sclerosis: A consensus statement from a urodynamic experts working group. Neurourol. Urodyn. 2020, 39, 73–82. [Google Scholar] [CrossRef] [PubMed]
- Litwiller, S.E.; Frohman, E.M.; Zimmern, P.E. Multiple sclerosis and the urologist. J. Urol. 1999, 161, 743–757. [Google Scholar] [CrossRef]
- Panicker, J.N.; Fowler, C.J.; Kessler, T.M. Lower urinary tract dysfunction in the neurological patient: Clinical assessment and management. Lancet Neurol. 2015, 14, 720–732. [Google Scholar] [CrossRef]
- Bientinesi, R.; Campetella, M.; Nociti, V.; Bassi, P.; Sacco, E. Identification of Brain Structures Involved in Lower Urinary Tract Symptoms and Sexual Dysfunctions in Patients with Multiple Sclerosis. Glob. J. Med. Res. 2021, 8. [Google Scholar]
- Madersbacher, H. The various types of neurogenic bladder dysfunction: An update of current therapeutic concepts. Spinal Cord 1990, 28, 217–229. [Google Scholar] [CrossRef]
- Minassian, V.A.; Drutz, H.P.; Al-Badr, A. Urinary incontinence as a worldwide problem. Int. J. Gynecol. Obstet. 2003, 82, 327–338. [Google Scholar] [CrossRef]
- Browne, C.; Salmon, N.; Kehoe, M. Bladder dysfunction and quality of life for people with multiple sclerosis. Disabil. Rehabil. 2015, 37, 2350–2358. [Google Scholar] [CrossRef]
- Medina-Polo, J.; Adot, J.M.; Allué, M.; Arlandis, S.; Blasco, P.; Casanova, B.; Matías-Guiu, J.; Madurga, B.; Meza-Murillo, E.; Müller-Arteaga, C.; et al. Consensus document on the multidisciplinary management of neurogenic lower urinary tract dysfunction in patients with multiple sclerosis. Neurourol. Urodyn. 2020, 39, 762–770. [Google Scholar] [CrossRef]
- Sacco, E.; Bientinesi, R. Innovative pharmacotherapies for women with overactive bladder: Where are we now and what is in the pipeline? Int. Urogynecol. J. 2015, 26, 629–640. [Google Scholar] [CrossRef]
- Schmidt, E.Z.; Hofmann, P.; Niederwieser, G.; Kapfhammer, H.-P.; Bonelli, R.M. Sexuality in multiple sclerosis. J. Neural Transm. 2005, 112, 1201–1211. [Google Scholar] [CrossRef] [PubMed]
- Bientinesi, R.; Sacco, E. Managing urinary incontinence in women—A review of new and emerging pharmacotherapy. Expert Opin. Pharmacother. 2018, 19, 1989–1997. [Google Scholar] [CrossRef] [PubMed]
- van Ophoven, A.; Engelberg, S.; Lilley, H.; Sievert, K.-D. Systematic Literature Review and Meta-Analysis of Sacral Neuromodulation (SNM) in Patients with Neurogenic Lower Urinary Tract Dysfunction (nLUTD): Over 20 Years’ Experience and Future Directions. Adv. Ther. 2021, 38, 1987–2006. [Google Scholar] [CrossRef] [PubMed]
- Cantone, E.; Massanova, M.; Crocetto, F.; Barone, B.; Esposito, F.; Arcaniolo, D.; Corlianò, F.; Romano, L.; Motta, G.; Celia, A. The relationship between obstructive sleep apnoea and erectile dysfunction: An underdiagnosed link? A prospective cross-sectional study. Andrologia 2022, 54, e14504. [Google Scholar] [CrossRef] [PubMed]
- Tepavcevic, D.K.; Kostic, J.; Basuroski, I.D.; Stojsavljevic, N.; Pekmezovic, T.; Drulovic, J. The impact of sexual dysfunction on the quality of life measured by MSQoL-54 in patients with multiple sclerosis. Mult. Scler. J. 2008, 14, 1131–1136. [Google Scholar] [CrossRef]
- Foley, F.W.; LaRocca, N.G.; Sanders, A.S.; Zemon, V. Rehabilitation of intimacy and sexual dysfunction in couples with multiple sclerosis. Mult. Scler. J. 2001, 7, 417–421. [Google Scholar] [CrossRef]
- Kessler, T.M.; Fowler, C.J.; Panicker, J.N. Sexual dysfunction in multiple sclerosis. Expert Rev. Neurother. 2009, 9, 341–350. [Google Scholar] [CrossRef]
- Li, V.; Haslam, C.; Pakzad, M.; Brownlee, W.J.; Panicker, J.N. A practical approach to assessing and managing sexual dysfunction in multiple sclerosis. Pract. Neurol. 2020, 20, 122–131. [Google Scholar] [CrossRef]
- Basson, R.; Rees, P.; Wang, R.; Montejo, A.L.; Incrocci, L. Sexual Function in Chronic Illness. J. Sex. Med. 2010, 7, 374–388. [Google Scholar] [CrossRef]
- Salonia, A.; Munarriz, R.; Naspro, R.; Nappi, R.; Briganti, A.; Chionna, R.; Federghini, F.; Mirone, V.; Rigatti, P.; Goldstein, I.; et al. Women’s sexual dysfunction: A pathophysiological review. Br. J. Urol. 2004, 93, 1156–1164. [Google Scholar] [CrossRef]
- Rosen, C.; Brown, J.; Heiman, S.; Leib, R. The Female Sexual Function Index (FSFI): A Multidimensional Self-Report Instrument for the Assessment of Female Sexual Function. J. Sex Marital. Ther. 2000, 26, 191–208. [Google Scholar] [CrossRef] [PubMed]
- Hulter, B.M.; Lundberg, O.P. Sexual function in women with advanced multiple sclerosis. J. Neurol. Neurosurg. Psychiatry 1995, 59, 83–86. [Google Scholar] [CrossRef] [PubMed]
- Alarcia-Alejos, R.; Ara-Callizo, J.R.; Martín-Martínez, J.; García-Gomara, M.J. Sexual dysfunction management in multiple scle-rosis. Rev. Neurol. 2007, 44, 524–526. [Google Scholar] [PubMed]
- Zivadinov, R.; Zorzon, M.; Bosco, A.; Bragadin, L.M.; Moretti, R.; Bonfigli, L.; Iona, L.G.; Cazzato, G. Sexual dysfunction in multiple sderosis: II. Correlation analysis. Mult. Scler. J. 1999, 5, 428–431. [Google Scholar] [CrossRef] [PubMed]
- Gava, G.; Visconti, M.; Salvi, F.; Bartolomei, I.; Seracchioli, R.; Meriggiola, M.C. Prevalence and Psychopathological Determinants of Sexual Dysfunction and Related Distress in Women with and Without Multiple Sclerosis. J. Sex. Med. 2019, 16, 833–842. [Google Scholar] [CrossRef] [PubMed]
- Mazzariol, C.; Di Tonno, F.; Piazza, N.; Pianon, C. Sexual Dysfunctions in Female with Neurological Disorders. Urol. J. 2010, 77, 21–27. [Google Scholar] [CrossRef]
- Christopherson, J.M.; Moore, K.; Foley, F.W.; Warren, K.G. A comparison of written materials vs. materials and counselling for women with sexual dysfunction and multiple sclerosis. J. Clin. Nurs. 2006, 15, 742–750. [Google Scholar] [CrossRef]
- Demirkiran, M.; Sarica, Y.; Uguz, S.; Yerdelen, D.; Aslan, K. Multiple sclerosis patients with and without sexual dysfunction: Are there any differences? Mult. Scler. J. 2006, 12, 209–211. [Google Scholar] [CrossRef]
- Borello-France, D.; Leng, W.; O’Leary, M.; Xavier, M.; Erickson, J.; Chancellor, M.B.; Cannon, T.W. Bladder and sexual function among women with multiple sclerosis. Mult. Scler. J. 2004, 10, 455–461. [Google Scholar] [CrossRef]
- Blackmore, D.E.; Hart, S.L.; Albiani, J.J.; Mohr, D.C. Improvements in partner support predict sexual satisfaction among individuals with multiple sclerosis. Rehabil. Psychol. 2011, 56, 117–122. [Google Scholar] [CrossRef] [Green Version]
- Hatzichristou, D.; Kirana, P.-S.; Banner, L.; Althof, S.E.; Lonnee-Hoffmann, R.; Dennerstein, L.; Rosen, R.C. Diagnosing Sexual Dysfunction in Men and Women: Sexual History Taking and the Role of Symptom Scales and Questionnaires. J. Sex. Med. 2016, 13, 1166–1182. [Google Scholar] [CrossRef] [PubMed]
- Drulovic, J.; Kisic-Tepavcevic, D.; Pekmezovic, T. Epidemiology, diagnosis and management of sexual dysfunction in multiple sclerosis. Acta Neurol. Belg. 2020, 120, 791–797. [Google Scholar] [CrossRef] [PubMed]
- Altmann, P.; Leithner, K.; Leutmezer, F.; Monschein, T.; Ponleitner, M.; Stattmann, M.; Rommer, P.S.; Zrzavy, T.; Zulehner, G.; Berek, K.; et al. Sexuality and Multiple Sclerosis: Patient and Doctor Perspectives. J. Sex. Med. 2021, 18, 743–749. [Google Scholar] [CrossRef] [PubMed]
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Bientinesi, R.; Gavi, F.; Coluzzi, S.; Nociti, V.; Marturano, M.; Sacco, E. Neurologic Urinary Incontinence, Lower Urinary Tract Symptoms and Sexual Dysfunctions in Multiple Sclerosis: Expert Opinions Based on the Review of Current Evidences. J. Clin. Med. 2022, 11, 6572. https://doi.org/10.3390/jcm11216572
Bientinesi R, Gavi F, Coluzzi S, Nociti V, Marturano M, Sacco E. Neurologic Urinary Incontinence, Lower Urinary Tract Symptoms and Sexual Dysfunctions in Multiple Sclerosis: Expert Opinions Based on the Review of Current Evidences. Journal of Clinical Medicine. 2022; 11(21):6572. https://doi.org/10.3390/jcm11216572
Chicago/Turabian StyleBientinesi, Riccardo, Filippo Gavi, Simone Coluzzi, Viviana Nociti, Monia Marturano, and Emilio Sacco. 2022. "Neurologic Urinary Incontinence, Lower Urinary Tract Symptoms and Sexual Dysfunctions in Multiple Sclerosis: Expert Opinions Based on the Review of Current Evidences" Journal of Clinical Medicine 11, no. 21: 6572. https://doi.org/10.3390/jcm11216572
APA StyleBientinesi, R., Gavi, F., Coluzzi, S., Nociti, V., Marturano, M., & Sacco, E. (2022). Neurologic Urinary Incontinence, Lower Urinary Tract Symptoms and Sexual Dysfunctions in Multiple Sclerosis: Expert Opinions Based on the Review of Current Evidences. Journal of Clinical Medicine, 11(21), 6572. https://doi.org/10.3390/jcm11216572