Next Article in Journal
Unraveling the Signaling Secretome of Platelet-Rich Plasma: Towards a Better Understanding of Its Therapeutic Potential in Knee Osteoarthritis
Previous Article in Journal
XR (Extended Reality: Virtual Reality, Augmented Reality, Mixed Reality) Technology in Spine Medicine: Status Quo and Quo Vadis

Correlates of Treatment and Disease Burden in People Living with HIV (PLHIV) in Italy

Infectious Diseases Unit, Fondazione Policlinico Universitario A. Gemelli—Università Cattolica Del Sacro Cuore, 00168 Rome, Italy
Icona Foundation, 20145 Milan, Italy
Division of Infectious Diseases, ASST Papa Giovanni XXIII, 24127 Bergamo, Italy
For CAB Icona Associazione Arcobaleno AIDS ODV, 10135 Torino, Italy
Clinic of Infectious Diseases, Department of Biomedical Sciences and Human Oncology, University of Bari “Aldo Moro”, 70124 Bari, Italy
Infectious Diseases Unit 1, Santa Maria Annunziata Hospital, Azienda USL Toscana Centro, 50012 Florence, Italy
Department of Infectious Diseases, IRCCS San Raffaele Scientific Institute, University Vita-Salute San Raffaele, 20127 Milan, Italy
Department of Infectious Diseases, University Hospital of Modena, 41125 Modena, Italy
University Department of Infectious and Tropical Diseases, University of Brescia, ASST Spedali Civili, 25123 Brescia, Italy
HIV/AIDS Department, INMI, L. Spallanzani, IRCCS, 00149 Rome, Italy
Clinic of Infectious Diseases, Department of Health Sciences, University of Milan, ASST Santi Paolo e Carlo, 20142 Milan, Italy
Author to whom correspondence should be addressed.
Membership of the Icona Foundation Study Group is provided in the Supplementary Material.
Academic Editor: Georgios Nikolopoulos
J. Clin. Med. 2022, 11(2), 471;
Received: 5 November 2021 / Revised: 5 January 2022 / Accepted: 13 January 2022 / Published: 17 January 2022
(This article belongs to the Section Infectious Diseases)
Treatment burden is a multidimensional concept, including several aspects of life of patients affected by chronic conditions. It has been poorly explored in people living with HIV (PLHIV). An online anonymous survey of PLHIV taking antiretroviral therapy (ART) was conducted, in order to investigate the self-reported correlates of disease burden. HIV Treatment and Diseases Burden (TDB) was investigated with a questionnaire containing 31 items in 7 domains. Respondents were stratified in high burden (H-TDB)/low burden (L-TDB) according to overall HIV TDB mean + 1 standard deviation. Factors associated with H-TDB has been evaluated with a logistic regression model. In total, 531 PLHIV completed the questionnaire. 99 PLHIV had a H-TDB (18.6%). PLHIV with H-TDB were younger (p < 0.001), less frequently on current two drug antiretroviral (ARV) regimens (p = 0.01) and more frequently with plasma HIV-RNA >50 copies/mL (p = 0.04). At multivariable regression analysis, younger age (aOR 1.43, 95%CI 1.14–1.80; p = 0.002), not fully treatment satisfaction (aOR 2.19, 95%CI 1.28–3.74; p = 0.004), the need of a more accurate dialogue with treating physician (aOR 2.29, 95%CI 1.21–4.36, p = 0.01) and a self-declared lower overall Health Status (aOR 1.75, 95%CI 1.33–2.32; p = 0.002) were all associated with a H-TDB. One out of five PLHIV showed a high level of treatment and disease burden. Younger age, not fully satisfaction with ART and need of interaction with a tailored health system should be taken into consideration as correlates of treatment and disease burden in a patient-centered approach, to reduce the negative impact that it can produce on the overall perceived health status of the person. View Full-Text
Keywords: treatment burden; HIV; antiretroviral; long acting treatment burden; HIV; antiretroviral; long acting
MDPI and ACS Style

Cingolani, A.; Tavelli, A.; Maggiolo, F.; Perziano, A.; Saracino, A.; Vichi, F.; Cernuschi, M.; Guaraldi, G.; Quiros-Roldan, E.; Castagna, A.; Antinori, A.; d’Arminio Monforte, A.; on behalf of Icona Foundation Study Group. Correlates of Treatment and Disease Burden in People Living with HIV (PLHIV) in Italy. J. Clin. Med. 2022, 11, 471.

AMA Style

Cingolani A, Tavelli A, Maggiolo F, Perziano A, Saracino A, Vichi F, Cernuschi M, Guaraldi G, Quiros-Roldan E, Castagna A, Antinori A, d’Arminio Monforte A, on behalf of Icona Foundation Study Group. Correlates of Treatment and Disease Burden in People Living with HIV (PLHIV) in Italy. Journal of Clinical Medicine. 2022; 11(2):471.

Chicago/Turabian Style

Cingolani, Antonella, Alessandro Tavelli, Franco Maggiolo, Annalisa Perziano, Annalisa Saracino, Francesca Vichi, Massimo Cernuschi, Giovanni Guaraldi, Eugenia Quiros-Roldan, Antonella Castagna, Andrea Antinori, Antonella d’Arminio Monforte, and on behalf of Icona Foundation Study Group. 2022. "Correlates of Treatment and Disease Burden in People Living with HIV (PLHIV) in Italy" Journal of Clinical Medicine 11, no. 2: 471.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop