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Article

Liver Injury in Patients with COVID-19 without Underlying Liver Disease

1
Department of Infectious Disease and Hepatology, Wroclaw Medical University, 50-367 Wroclaw, Poland
2
Department of Infectious Diseases, Regional Specialistic Hospital, 50-149 Wroclaw, Poland
3
Department of Internal Medicine and Geriatrics, Faculty of Medicine, Jagiellonian University Medical College, 31-008 Kraków, Poland
4
Department of Endoscopy, University Hospital in Kraków, 30-688 Kraków, Poland
5
Department of Pharmaceutical Biochemistry, Wroclaw Medical University, 50-556 Wroclaw, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Yasuhito Tanaka
J. Clin. Med. 2022, 11(2), 308; https://doi.org/10.3390/jcm11020308
Received: 1 December 2021 / Revised: 20 December 2021 / Accepted: 31 December 2021 / Published: 8 January 2022
(This article belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
SARS-CoV-2 shows a high affinity for the ACE-2 receptor, present on the epithelial cells of the upper and lower respiratory tract, within the intestine, kidneys, heart, testes, biliary epithelium, and—where it is particularly challenging—on vascular endothelial cells. Liver involvement is a rare manifestation of COVID-19. Material and Methods: We reviewed 450 patients admitted due to the fact of SARS-CoV-2 infection (COVID-19) including 88 with liver injury. Based on medical history and previous laboratory test results, we excluded cases of underlying liver disease. The analysis involved a clinical course of COVID-19 in patients without underlying liver disease as well as the type and course of liver injury. Results: Signs and symptoms of liver injury were present in 20% of patients, mostly presenting as a mixed-type pattern of injury with less common cases of standalone hepatocellular (parenchymal) or cholestatic injury. The liver injury symptoms resolved at the end of inpatient treatment in 20% of cases. Sixteen patients died with no cases where liver injury would be deemed a cause of death. Conclusions: (1) Liver injury secondary to COVID-19 was mild, and in in 20%, the signs and symptoms of liver injury resolved by the end of hospitalization. (2) It seems that liver injury in patients with COVID-19 was not associated with a higher risk of mortality. (3) The underlying mechanism of liver injury as well as its sequelae are not fully known. Therefore, caution and further monitoring are advised, especially in patients whose liver function tests have not returned to normal values. View Full-Text
Keywords: SARS-CoV-2 infection; liver injury; cholestasis SARS-CoV-2 infection; liver injury; cholestasis
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MDPI and ACS Style

Pazgan-Simon, M.; Serafińska, S.; Kukla, M.; Kucharska, M.; Zuwała-Jagiełło, J.; Buczyńska, I.; Zielińska, K.; Simon, K. Liver Injury in Patients with COVID-19 without Underlying Liver Disease. J. Clin. Med. 2022, 11, 308. https://doi.org/10.3390/jcm11020308

AMA Style

Pazgan-Simon M, Serafińska S, Kukla M, Kucharska M, Zuwała-Jagiełło J, Buczyńska I, Zielińska K, Simon K. Liver Injury in Patients with COVID-19 without Underlying Liver Disease. Journal of Clinical Medicine. 2022; 11(2):308. https://doi.org/10.3390/jcm11020308

Chicago/Turabian Style

Pazgan-Simon, Monika, Sylwia Serafińska, Michał Kukla, Marta Kucharska, Jolanta Zuwała-Jagiełło, Iwona Buczyńska, Kamila Zielińska, and Krzysztof Simon. 2022. "Liver Injury in Patients with COVID-19 without Underlying Liver Disease" Journal of Clinical Medicine 11, no. 2: 308. https://doi.org/10.3390/jcm11020308

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