Initial Vestibular Function May Be Associated with Future Postural Instability in Parkinson’s Disease
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patients
2.2. VEMP Recordings and Measurements
2.3. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Conflicts of Interest
References
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No Postural Instability n = 19 | Yes Postural Instability n = 12 | p *-Value | |||
---|---|---|---|---|---|
Clinical Characteristics | |||||
Initial Visit | |||||
Age, years | 60.6 ± 7.6 | 62.9 ± 9.8 | 0.459 | ||
Women, n (%) | 12 (63.2) | 4 (33.3) | 0.106 | ||
Duration of disease, years | 2.5 ± 1.2 | 3.8 ± 2.7 | 0.326 | ||
K-MMSE | 26.9 ± 3.6 | 26.3 ± 2.7 | 0.326 | ||
Education, years | 9.5 ± 5.0 | 11.5 ± 4.1 | 0.328 | ||
Orthostatic hypotension, n (%) | 0.280 | ||||
not checked | 4 (21.1) | 2 (16.7) | |||
no | 14 (73.7) | 7 (58.3) | |||
yes | 1 (5.3) | 3 (25.0) | |||
HY stage | 1.3 ± 0.7 | 2.3 ± 0.3 | 0.000 | ||
UPDRS III | 12.8 ± 8.3 | 20.0 ± 6.3 | 0.006 | ||
Item 27 | 0.1 ± 0.3 | 0.1 ± 0.3 | 0.921 | ||
Item 28 | 0.2 ± 0.4 | 0.5 ± 0.5 | 0.191 | ||
Item 29 | 0.1 ± 0.3 | 0.4 ± 0.5 | 0.152 | ||
Item 30 | 0.2 ± 0.4 | 0.6 ± 0.5 | 0.048 | ||
Total LEDD | 399.9 ± 210.8 | 424.8 ± 293.1 | 0.120 | ||
Follow-up visit | |||||
K-MMSE | 26.8 ± 3.6 | 25.7 ± 3.9 | 0.509 | ||
HY stage | 1.6 ± 0.4 | 2.5 ± 0.0 | 0.000 | ||
UPDRS III | 12.5 ± 6.4 | 19.3 ± 7.1 | 0.016 | ||
Item 27 | 0.1 ± 0.2 | 0.6 ± 0.5 | 0.012 | ||
Item 28 | 0.1 ± 0.2 | 0.9 ± 0.5 | 0.000 | ||
Item 29 | 0.1 ± 0.3 | 0.8 ± 0.5 | 0.002 | ||
Item 30 | 0.0 ± 0.0 | 1.0 ± 0.0 | - | ||
Total LEDD | 439.0 ± 174.5 | 507.3 ± 262.8 | 0.509 | ||
Dizziness severity | 0.3 ± 0.5 | 0.5 ± 0.5 | 0.412 | ||
Interval between initial and follow-up visit, months | 30.0 ± 8.6 | 25.7 ± 8.1 | 0.191 |
No Postural Instability n = 19 | Yes Postural Instability n = 12 | p *-Value | |||
---|---|---|---|---|---|
VEMP Parameters of Initial Visit | |||||
oVEMP | |||||
Left | |||||
N1 latency (ms) | 12.7 ± 1.2 | 12.4 ± 2.4 | 0.733 | ||
P1 latency (ms) | 17.3 ± 1.1 | 15.6 ± 2.7 | 0.186 | ||
N1-P1 amplitude (μV) | 2.4 ± 3.0 | 1.6 ± 1.1 | 0.795 | ||
Right | |||||
N1 latency (ms) | 13.0 ± 1.6 | 13.0 ± 2.7 | 0.979 | ||
P1 latency (ms) | 17.4 ± 1.1 | 16.2 ± 2.8 | 0.373 | ||
N1-P1 amplitude (μV) | 1.9 ± 1.6 | 1.4 ± 0.8 | 0.459 | ||
cVEMP | |||||
Left | |||||
P13 latency (ms) | 15.8 ± 3.8 | 14.7 ± 2.3 | 0.458 | ||
N23 latency (ms) | 24.0 ± 4.4 | 21.0 ± 1.7 | 0.013 | ||
P13-N23 amplitude (μV) | 123.4 ± 157.2 | 82.3 ± 61.5 | 0.412 | ||
Right | |||||
P13 latency (ms) | 16.2 ± 36.5 | 15.0 ± 2.0 | 0.604 | ||
N23 latency (ms) | 24.5 ± 4.7 | 21.3 ± 2.0 | 0.040 | ||
P13-N23 amplitude (μV) | 116.9 ± 98.5 | 72.2 ± 67.3 | 0.152 |
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Park, J.H.; Kim, M.S.; Kang, S.Y. Initial Vestibular Function May Be Associated with Future Postural Instability in Parkinson’s Disease. J. Clin. Med. 2022, 11, 5608. https://doi.org/10.3390/jcm11195608
Park JH, Kim MS, Kang SY. Initial Vestibular Function May Be Associated with Future Postural Instability in Parkinson’s Disease. Journal of Clinical Medicine. 2022; 11(19):5608. https://doi.org/10.3390/jcm11195608
Chicago/Turabian StylePark, Jeong Ho, Min Seung Kim, and Suk Yun Kang. 2022. "Initial Vestibular Function May Be Associated with Future Postural Instability in Parkinson’s Disease" Journal of Clinical Medicine 11, no. 19: 5608. https://doi.org/10.3390/jcm11195608
APA StylePark, J. H., Kim, M. S., & Kang, S. Y. (2022). Initial Vestibular Function May Be Associated with Future Postural Instability in Parkinson’s Disease. Journal of Clinical Medicine, 11(19), 5608. https://doi.org/10.3390/jcm11195608