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Systematic Review

Characteristics and Clinical Ocular Manifestations in Patients with Acute Corneal Graft Rejection after Receiving the COVID-19 Vaccine: A Systematic Review

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Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo 113-0033, Japan
2
Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo 113-0033, Japan
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Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA
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Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki 852-8102, Japan
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Department of Health Services Research, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan
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Department of Hospital Administration, Juntendo University Graduate School of Medicine, Tokyo 113-0033, Japan
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AI Incubation Farm, Juntendo University Graduate School of Medicine, Tokyo 113-0033, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Cosimo Mazzotta
J. Clin. Med. 2022, 11(15), 4500; https://doi.org/10.3390/jcm11154500
Received: 20 June 2022 / Revised: 30 July 2022 / Accepted: 31 July 2022 / Published: 2 August 2022
This study aimed to determine the characteristics and clinical ocular manifestations of acute corneal graft rejection after coronavirus disease 2019 (COVID-19) vaccination. We conducted an online search of the PubMed and EMBASE databases. Data on recipients’ characteristics, corneal transplantation types, interval between vaccination and allograft rejection, clinical manifestations, and graft rejection medication were extracted. Thirteen articles on 21 patients (23 eyes) with acute corneal graft rejection after COVID-19 vaccination, published between April and December 2021, were included. The median (interquartile range) age at the onset of rejection was 68 (27–83) years. Types of transplantation included penetrating keratoplasty (12 eyes), Descemet membrane endothelial keratoplasty (six eyes), Descemet stripping automated endothelial keratoplasty (four eyes), and living-related conjunctival-limbal allograft (one eye). The interval between vaccination and rejection ranged from 1 day to 6 weeks. Corneal edema was the leading clinical manifestation (20 eyes), followed by keratic precipitates (14 eyes) and conjunctival or ciliary injection (14 eyes). Medications included frequently applied topical corticosteroids (12 eyes), followed by a combination of topical and oral corticosteroids (four eyes). In addition, the clinical characteristics of corneal allograft rejection after COVID-19 vaccination were identified. Corneal transplant recipients may require further vaccination, necessitating appropriate management and treatment. View Full-Text
Keywords: coronavirus disease 2019 (COVID-19); SARS-CoV-2; vaccine; corneal transplantation; corneal graft; immune response; tolerance; corneal graft rejection; systematic review coronavirus disease 2019 (COVID-19); SARS-CoV-2; vaccine; corneal transplantation; corneal graft; immune response; tolerance; corneal graft rejection; systematic review
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MDPI and ACS Style

Fujio, K.; Sung, J.; Nakatani, S.; Yamamoto, K.; Iwagami, M.; Fujimoto, K.; Shokirova, H.; Okumura, Y.; Akasaki, Y.; Nagino, K.; Midorikawa-Inomata, A.; Hirosawa, K.; Miura, M.; Huang, T.; Morooka, Y.; Kuwahara, M.; Murakami, A.; Inomata, T. Characteristics and Clinical Ocular Manifestations in Patients with Acute Corneal Graft Rejection after Receiving the COVID-19 Vaccine: A Systematic Review. J. Clin. Med. 2022, 11, 4500. https://doi.org/10.3390/jcm11154500

AMA Style

Fujio K, Sung J, Nakatani S, Yamamoto K, Iwagami M, Fujimoto K, Shokirova H, Okumura Y, Akasaki Y, Nagino K, Midorikawa-Inomata A, Hirosawa K, Miura M, Huang T, Morooka Y, Kuwahara M, Murakami A, Inomata T. Characteristics and Clinical Ocular Manifestations in Patients with Acute Corneal Graft Rejection after Receiving the COVID-19 Vaccine: A Systematic Review. Journal of Clinical Medicine. 2022; 11(15):4500. https://doi.org/10.3390/jcm11154500

Chicago/Turabian Style

Fujio, Kenta, Jaemyoung Sung, Satoru Nakatani, Kazuko Yamamoto, Masao Iwagami, Keiichi Fujimoto, Hurramhon Shokirova, Yuichi Okumura, Yasutsugu Akasaki, Ken Nagino, Akie Midorikawa-Inomata, Kunihiko Hirosawa, Maria Miura, Tianxiang Huang, Yuki Morooka, Mizu Kuwahara, Akira Murakami, and Takenori Inomata. 2022. "Characteristics and Clinical Ocular Manifestations in Patients with Acute Corneal Graft Rejection after Receiving the COVID-19 Vaccine: A Systematic Review" Journal of Clinical Medicine 11, no. 15: 4500. https://doi.org/10.3390/jcm11154500

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