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Volume 11
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10.3390/jcm11154433
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Article

Time to Surgery Does Not Affect Overall or Disease-Free Survival of Patients with Primary Resectable PDAC

by
Anne Jacobsen
,
Mirianna Hobbs
,
Susanne Merkel
,
Anke Mittelstädt
,
Franziska Czubayko
,
Christian Krautz
,
Georg F. Weber
,
Robert Grützmann
and
Maximilian Brunner
*
Department of General and Visceral Surgery, Friedrich-Alexander-University (FAU Erlangen-Nuremberg), Krankenhausstrasse 12, 91054 Erlangen, Germany
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2022, 11(15), 4433; https://doi.org/10.3390/jcm11154433
Submission received: 20 July 2022 / Revised: 26 July 2022 / Accepted: 28 July 2022 / Published: 29 July 2022
(This article belongs to the Special Issue State-of-the-Art in Pancreatic Surgery)
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Abstract

(1) Background: Delay in therapy for pancreatic ductal adenocarcinoma (PDAC) may contribute to a worse outcome. The aim of this study was to investigate the prognostic value of time from diagnosis to surgery in patients undergoing upfront surgery for primarily resectable pancreatic carcinoma. (2) Methods: This retrospective single-center study included 214 patients who underwent primary resection of PDAC from January 2000 to December 2018 at University Hospital Erlangen. Using a minimum p-value approach, patients were stratified according to time to surgery (TtS) into two groups: TtS ≤ 23 days and TtS > 23 days. Postoperative outcome and long-term survival were compared. (3) Results: Median TtS was 25 days. The best cut-off for TtS was determined as 23 days. There were no differences regarding postoperative outcome or overall survival (OS) and disease-free survival (DFS) (OS: 23.8 vs. 20.4 months, p = 0.210, respectively, and DFS: 15.8 vs. 13.6 months, p = 0.187). Multivariate analysis revealed age, lymph node metastasis, tumor differentiation and resection status as significant independent prognostic predictors for OS and DFS. (4) Conclusions: A delay of surgery > 23 days after first diagnosis does not affect overall or disease-free survival of patients with primary resectable PDAC. However, the psychological impact of a delay to patients waiting for surgery should not be underestimated.
Keywords: pancreatic ductal adenocarcinoma; primary resection; overall survival; disease-free survival; time to surgery pancreatic ductal adenocarcinoma; primary resection; overall survival; disease-free survival; time to surgery

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MDPI and ACS Style

Jacobsen, A.; Hobbs, M.; Merkel, S.; Mittelstädt, A.; Czubayko, F.; Krautz, C.; Weber, G.F.; Grützmann, R.; Brunner, M. Time to Surgery Does Not Affect Overall or Disease-Free Survival of Patients with Primary Resectable PDAC. J. Clin. Med. 2022, 11, 4433. https://doi.org/10.3390/jcm11154433

AMA Style

Jacobsen A, Hobbs M, Merkel S, Mittelstädt A, Czubayko F, Krautz C, Weber GF, Grützmann R, Brunner M. Time to Surgery Does Not Affect Overall or Disease-Free Survival of Patients with Primary Resectable PDAC. Journal of Clinical Medicine. 2022; 11(15):4433. https://doi.org/10.3390/jcm11154433

Chicago/Turabian Style

Jacobsen, Anne, Mirianna Hobbs, Susanne Merkel, Anke Mittelstädt, Franziska Czubayko, Christian Krautz, Georg F. Weber, Robert Grützmann, and Maximilian Brunner. 2022. "Time to Surgery Does Not Affect Overall or Disease-Free Survival of Patients with Primary Resectable PDAC" Journal of Clinical Medicine 11, no. 15: 4433. https://doi.org/10.3390/jcm11154433

APA Style

Jacobsen, A., Hobbs, M., Merkel, S., Mittelstädt, A., Czubayko, F., Krautz, C., Weber, G. F., Grützmann, R., & Brunner, M. (2022). Time to Surgery Does Not Affect Overall or Disease-Free Survival of Patients with Primary Resectable PDAC. Journal of Clinical Medicine, 11(15), 4433. https://doi.org/10.3390/jcm11154433

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