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Article

Association between Timing of Epinephrine Administration and Outcomes of Traumatic Out-of-Hospital Cardiac Arrest following Traffic Collisions

1
Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, 2-15 Yamada-oka, Suita 565-0871, Japan
2
Division of Environmental Medicine and Population Sciences, Department of Social Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita 565-0871, Japan
3
Department of Food Science, Faculty of Home Economics, Otsuma Women’s University, 12 Sanban-cho, Chiyoda-ku, Tokyo 102-8357, Japan
4
Department of Emergency Medicine, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto 602-8566, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Andrea Igoren Guaricci
J. Clin. Med. 2022, 11(12), 3564; https://doi.org/10.3390/jcm11123564
Received: 10 May 2022 / Revised: 28 May 2022 / Accepted: 20 June 2022 / Published: 20 June 2022
(This article belongs to the Special Issue Ventricular Arrhythmias and Sudden Cardiac Death (SCD))
The effects of epinephrine administration timing on patients with out-of-hospital cardiac arrest (OHCA) following traffic collisions are unknown. We analyzed the 2013–2019 All-Japan Utstein Registry data of 2024 such patients aged ≥18 years who were resuscitated by emergency medical service (EMS) personnel or bystanders and then transported to medical institutions. Time from 119 call to epinephrine administration was classified into quartiles: Q1 (6–21 min), Q2 (22–26 min), Q3 (27–34 min), and Q4 (35–60 min). Multivariable logistic regression analysis was used to assess the effects of epinephrine administration timing on one-month survival after OHCA. Overall, the one-month survival rates were 3.2% (15/466) in Q1, 1.1% (5/472) in Q2, 1.9% (11/577) in Q3, and 0.2% (1/509) in Q4. Additionally, the one-month survival rate decreased significantly in the Q4 group (adjusted odds ratio, 0.07; 95% confidence interval, 0.01–0.57) compared with the Q1 group, and the probability of one-month survival decreased as the time from the EMS call to epinephrine administration increased (p-value for trend = 0.009). Only four patients (0.9% [4/466]) with the earliest epinephrine administration showed a good neurological outcome. View Full-Text
Keywords: traffic collision; mortality; out-of-hospital cardiac arrest; trauma; Japan traffic collision; mortality; out-of-hospital cardiac arrest; trauma; Japan
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MDPI and ACS Style

Hosomi, S.; Kitamura, T.; Sobue, T.; Zha, L.; Kiyohara, K.; Matsuyama, T.; Oda, J. Association between Timing of Epinephrine Administration and Outcomes of Traumatic Out-of-Hospital Cardiac Arrest following Traffic Collisions. J. Clin. Med. 2022, 11, 3564. https://doi.org/10.3390/jcm11123564

AMA Style

Hosomi S, Kitamura T, Sobue T, Zha L, Kiyohara K, Matsuyama T, Oda J. Association between Timing of Epinephrine Administration and Outcomes of Traumatic Out-of-Hospital Cardiac Arrest following Traffic Collisions. Journal of Clinical Medicine. 2022; 11(12):3564. https://doi.org/10.3390/jcm11123564

Chicago/Turabian Style

Hosomi, Sanae, Tetsuhisa Kitamura, Tomotaka Sobue, Ling Zha, Kosuke Kiyohara, Tasuku Matsuyama, and Jun Oda. 2022. "Association between Timing of Epinephrine Administration and Outcomes of Traumatic Out-of-Hospital Cardiac Arrest following Traffic Collisions" Journal of Clinical Medicine 11, no. 12: 3564. https://doi.org/10.3390/jcm11123564

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