Drugs and Vaccines Hypersensitivity in Children with Mastocytosis
Abstract
:1. Introduction
2. Findings in Anaphylactic Reactions
3. Drug Hypersensitivity Reactions in Mastocytosis
3.1. General Anesthesia
3.2. Local Anesthesia
3.3. Radiocontrast Media
3.4. Antibiotics
3.5. Nonsteroidal Anti-Inflammatory Drugs
3.6. Other Drugs
4. Vaccines for Infectious Diseases
5. Discussion
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Conflicts of Interest
References
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Authors | Patients with Reactions/Total Sample | Variant of Mastocytosis/Age of Diagnosis (Years) | Eliciting Vaccine (Number of Doses Received) | Reaction/Time Interval | Subsequent Vaccines/ Premedication |
---|---|---|---|---|---|
Zanoni et al. [66] | 7/102 (35 children) | Mastocytoma/0.5 Mastocytoma/0.4 Mastocytoma/2 Mastocytoma/0.6 MPCM/0.2 MPCM/0.5 DCM/0.4 | Hexavalent (1) Hexavalent (2) MenC (1) Hexavalent (3) PCV (2), MenC (1) HPV (1) Hexavalent (1,2), PCV (1, 2) | Urticaria and angioedema/20 min Local and facial flushing/20 min Fever and gastrointestinal clinical manifestations/24 h Injection site reaction and fever/8 h Fever/8 h Hives on arm and nasal obstruction/12 h Hives and itch on trunk and febrile convulsions/12 h | DTaP, IPV, HB, Hib, MMRV/not available Hexavalent/not available PCV/not available |
Parente et al. [69] | 4/72 children | MPCM/0.3 Mastocytoma/2 Mastocytoma/4 DCM/0.1 | Hexavalent (1) Hexavalent (1) Hexavalent (1) Hexavalent (1) | Bullous skin reaction/6–12 h Diffuse urticaria/1–4 h Diffuse urticaria/1–4 h Bullous skin reaction and mild bronchospasm/6–12 h | Other mandatory vaccines/oral antihistamines Other mandatory vaccines Other mandatory vaccines Other mandatory vaccines/oral antihistamines |
Bankova et al. [70] | 1 child | DCM | DTaP IPV HiB Rotavirus | Confluent blisters on the back, abdomen, and upper arms/a day later | Unknown/oral and topical sodium cromolyn |
Johansen et al. [71] | 1 child3/35 children | MPCM MPCM MPCM | DTaP IPV HiB Rotavirus DTaP All vaccines | Skin flushing, itch, blisters, gastrointestinal clinical manifestations/hours Skin flushing and pruritus/minutes Fever/hours | |
Sarcina et al. [64] | 1 child | MPCM | inactivated tetravalent influenza vaccine (2) | diffuse bullous cutaneous reaction/24 h | PCV13; V vaccines oral antihistamines and betamethasone (background therapy with ketotifen) |
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Mori, F.; Crisafulli, G.; Bianchi, A.; Bottau, P.; Caimmi, S.; Franceschini, F.; Liotti, L.; Paglialunga, C.; Saretta, F.; Caffarelli, C. Drugs and Vaccines Hypersensitivity in Children with Mastocytosis. J. Clin. Med. 2022, 11, 3153. https://doi.org/10.3390/jcm11113153
Mori F, Crisafulli G, Bianchi A, Bottau P, Caimmi S, Franceschini F, Liotti L, Paglialunga C, Saretta F, Caffarelli C. Drugs and Vaccines Hypersensitivity in Children with Mastocytosis. Journal of Clinical Medicine. 2022; 11(11):3153. https://doi.org/10.3390/jcm11113153
Chicago/Turabian StyleMori, Francesca, Giuseppe Crisafulli, Annamaria Bianchi, Paolo Bottau, Silvia Caimmi, Fabrizio Franceschini, Lucia Liotti, Claudia Paglialunga, Francesca Saretta, and Carlo Caffarelli. 2022. "Drugs and Vaccines Hypersensitivity in Children with Mastocytosis" Journal of Clinical Medicine 11, no. 11: 3153. https://doi.org/10.3390/jcm11113153