Comparison of Postoperative Gastrointestinal Motility of Sugammadex and Neostigmine in Patients Undergoing Robotic Thyroidectomy: A Retrospective Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Population
2.2. Clinical Practice
2.3. Data Collection and Outcomes
2.4. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Variables | Neostigmine (n = 60) | Sugammadex (n = 62) | p-Value |
---|---|---|---|
Age, years | 39 ± 10 | 37 ± 10 | 0.135 |
Female sex | 55 (92) | 60 (97) | 0.269 |
Body mass index, kg m−2 | 22.5 ± 3.2 | 23.1 ± 3.7 | 0.629 |
ASA physical status | 0.592 | ||
I | 46 (77) | 50 (81) | |
II | 14 (23) | 12 (19) | |
Co-morbidities | |||
Hypertension | 5 (8) | 1 (2) | 0.111 |
Diabetes mellitus | 1 (2) | 0 (0) | 0.492 |
Liver disease | 2 (3) | 1 (2) | 0.616 |
Preoperative laboratory value | |||
T3, pg/mL | 0.90 ± 0.13 | 0.96 ± 0.20 | 0.065 |
T4, ng/dL | 1.09 ± 0.22 | 1.09 ± 0.17 | 0.521 |
TSH, mIU/L | 1.67 ± 1.11 | 1.49 ± 0.92 | 0.538 |
Serum calcium, mg/dL | 9.51 ± 0.32 | 9.54 ± 0.31 | 0.580 |
Variables | Neostigmine (n = 60) | Sugammadex (n = 62) | p-Value |
---|---|---|---|
Duration of anesthesia, min | 149 ± 39 | 140 ± 31 | 0.120 |
Sevoflurane/desflurane | 3/57 (5/95) | 4/58 (6/94) | >0.999 |
Intraoperative administered remifentanil, µg | 494 ± 173 | 471 ± 171 | 0.472 |
Intraoperative administered rocuronium, mg | 55 ± 8 | 53 ± 13 | 0.287 |
Intraoperative use of opioid, n | 15 (25) | 27 (44) | 0.031 * |
Intraoperative total fluid intake, mL | 608 ± 154 | 608 ± 173 | 0.985 |
Subtotal/total thyroidectomy | 50/10 (83/17) | 54/8 (87/13) | 0.558 |
Duration of PACU stay, min | 37 ± 11 | 35 ± 9 | 0.193 |
Additional antiemetics in PACU, n | 2 (3) | 7 (11) | 0.164 |
Serum calcium at POD 1, mg/dL | 8.69 ± 0.36 | 8.72 ± 0.41 | 0.529 |
Hypocalcemia at POD 1, n | 10 (22) | 9 (21) | 0.883 |
Length of postoperative hospital stays, days | 3.1 ± 0.3 | 3.0 ± 0.3 | 0.363 |
Variables | Neostigmine (n = 60) | Sugammadex (n = 62) | p-Value |
---|---|---|---|
Patients who passed gas > 12 h | 35 (58) | 26 (42) | 0.070 |
Patients who passed gas ≤ 12 h | 25 (42) | 36 (58) | |
Patients who passed gas > 24 h | 17 (28) | 6 (10) | 0.008 * |
Patients who passed gas ≤ 24 h | 43 (72) | 56 (90) | |
Postoperative constipation | 16 (27) | 9 (15) | 0.097 |
Variables | Univariate | Multivariate | ||
---|---|---|---|---|
OR (95% CI) | p-Value | OR (95% CI) | p-Value | |
Group | ||||
Neostigmine | 1 | 1 | ||
Sugammadex | 3.69 (1.34–10.15) | 0.012 * | 4.60 (1.59–13.30) | 0.005 * |
Female sex | 0.71 (0.08–6.16) | 0.752 | ||
Age, year | 0.99 (0.94–1.03) | 0.520 | ||
Body mass index, kg m−2 | 1.12 (0.96–1.30) | 0.141 | ||
ASA physical status | ||||
I | 1 | |||
II | 0.55 (0.23–1.34) | 0.188 | ||
Anesthetic agent | ||||
Sevoflurane | 1 | |||
Desflurane | 0.74 (0.52–3.44) | 0.698 | ||
Remifentanil, 10 µg increase | 1.03 (0.99–1.06) | 0.115 | 1.03 (1.00–1.07) | 0.094 |
Intraoperative use of opioid | 0.78 (0.31–1.98) | 0.599 | 0.48 (0.17–1.36) | 0.169 |
Rocuronium, 1 mg increase | 1.02 (0.98–1.07) | 0.379 | ||
Type of thyroidectomy | ||||
Subtotal | 1 | |||
Total | 2.02 (0.43–9.50) | 0.371 | ||
Total fluid intake, 100 mL increase | 1.08 (0.81–1.44) | 0.591 | ||
Duration of anesthesia, 5 min increase | 1.00 (0.93–1.06) | 0.904 | ||
Duration of PACU stay, 5 min increase | 1.02 (0.98–1.06) | 0.376 |
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Lee, M.J.; Chun, D.-H.; Kong, H.J.; Shin, H.J.; Yang, S.; Kim, N.Y. Comparison of Postoperative Gastrointestinal Motility of Sugammadex and Neostigmine in Patients Undergoing Robotic Thyroidectomy: A Retrospective Study. J. Clin. Med. 2022, 11, 2930. https://doi.org/10.3390/jcm11102930
Lee MJ, Chun D-H, Kong HJ, Shin HJ, Yang S, Kim NY. Comparison of Postoperative Gastrointestinal Motility of Sugammadex and Neostigmine in Patients Undergoing Robotic Thyroidectomy: A Retrospective Study. Journal of Clinical Medicine. 2022; 11(10):2930. https://doi.org/10.3390/jcm11102930
Chicago/Turabian StyleLee, Min Jeong, Duk-Hee Chun, Hee Jung Kong, Hye Jung Shin, Sunmo Yang, and Na Young Kim. 2022. "Comparison of Postoperative Gastrointestinal Motility of Sugammadex and Neostigmine in Patients Undergoing Robotic Thyroidectomy: A Retrospective Study" Journal of Clinical Medicine 11, no. 10: 2930. https://doi.org/10.3390/jcm11102930
APA StyleLee, M. J., Chun, D.-H., Kong, H. J., Shin, H. J., Yang, S., & Kim, N. Y. (2022). Comparison of Postoperative Gastrointestinal Motility of Sugammadex and Neostigmine in Patients Undergoing Robotic Thyroidectomy: A Retrospective Study. Journal of Clinical Medicine, 11(10), 2930. https://doi.org/10.3390/jcm11102930