Admission Dehydration Status Portends Adverse Short-Term Mortality in Patients with Spontaneous Intracerebral Hemorrhage
Abstract
:1. Introduction
2. Materials and Methods
3. Statistics
4. Results
4.1. Patient Characteristics
4.2. Admission Dehydration Status
4.3. Multivariate Analysis
5. Discussion
6. Conclusions
7. Limitations
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Patients with Spontaneous ICH, n = 249 | |
---|---|
Median age (years, IQR) | 76 (65–82) |
Female sex | 128 (51%) |
Anticoagulation/antiplatelet medication prior ictus | 125 (50%) |
Pre-existing hypertension | 204 (82%) |
Pre-existing diuretic treatment | 77 (31%) |
Initial ICH score > 3 | 48 (19%) |
GCS ≥ 13 | 122 (49%) |
patient age ≥ 80 years | 83 (33%) |
infratentorial location | 37 (15%) |
ICH volume ≥ 30 mL | 105 (42%) |
presence of IVH | 114 (46%) |
Presence of clinical signs of herniation at admission | 41 (17%) |
MLS > 5 mm | 62 (25%) |
Surgical treatment | 65 (26%) |
Short-term mortality | 101 (41%) |
Non-Dehydration U/Cr ≤ 80, n = 173 | Dehydration U/Cr > 80, n = 76 | ||
---|---|---|---|
Median age (years, IQR) | 75 (63–82) | 76 (70–82) | p < 0.001 |
Female sex | 77 (45%) | 51 (67%) | p = 0.001, OR |
Anticoagulation/antiplatelet medication prior ictus | 86 (50%) | 39 (51%) | p = 0.9 |
Pre-existing hypertension | 140 (81%) | 64 (84%) | p = 0.6 |
Pre-existing diuretic treatment | 56 (32%) | 21 (28%) | p = 0.6 |
Supratentorial ICH location | 151 (87%) | 61 (80%) | p = 0.2 |
ICH volume ≥ 30 mL | 59 (34%) | 46 (61%) | p < 0.001, OR 3.0, 95% CI 1.7–5.2 |
Presence of IVH | 66 (38%) | 48 (63%) | p < 0.001, OR 2.8, 95% CI 1.6–4.9 |
Initial ICH score > 3 | 21 (12%) | 27 (36%) | p < 0.001, OR 3.9, 95% CI 2.1–7.7 |
Presence of clinical signs of herniation at admission | 21 (12%) | 20 (26%) | p = 0.009, OR 2.6, 95% CI 1.3–5.1 |
MLS > 5 mm | 32 (18%) | 30 (39%) | p = 0.001, OR 2.9, 95% CI 1.6–5.2 |
Short-term mortality | 53 (31%) | 48 (63%) | p < 0.001, OR 3.9, 95% CI 2.2–6.8 |
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Lehmann, F.; Schenk, L.M.; Bernstock, J.D.; Bode, C.; Borger, V.; Gessler, F.; Güresir, E.; Hamed, M.; Potthoff, A.-L.; Putensen, C.; et al. Admission Dehydration Status Portends Adverse Short-Term Mortality in Patients with Spontaneous Intracerebral Hemorrhage. J. Clin. Med. 2021, 10, 5939. https://doi.org/10.3390/jcm10245939
Lehmann F, Schenk LM, Bernstock JD, Bode C, Borger V, Gessler F, Güresir E, Hamed M, Potthoff A-L, Putensen C, et al. Admission Dehydration Status Portends Adverse Short-Term Mortality in Patients with Spontaneous Intracerebral Hemorrhage. Journal of Clinical Medicine. 2021; 10(24):5939. https://doi.org/10.3390/jcm10245939
Chicago/Turabian StyleLehmann, Felix, Lorena M. Schenk, Joshua D. Bernstock, Christian Bode, Valeri Borger, Florian Gessler, Erdem Güresir, Motaz Hamed, Anna-Laura Potthoff, Christian Putensen, and et al. 2021. "Admission Dehydration Status Portends Adverse Short-Term Mortality in Patients with Spontaneous Intracerebral Hemorrhage" Journal of Clinical Medicine 10, no. 24: 5939. https://doi.org/10.3390/jcm10245939
APA StyleLehmann, F., Schenk, L. M., Bernstock, J. D., Bode, C., Borger, V., Gessler, F., Güresir, E., Hamed, M., Potthoff, A.-L., Putensen, C., Schneider, M., Zimmermann, J., Vatter, H., Schuss, P., & Hadjiathanasiou, A. (2021). Admission Dehydration Status Portends Adverse Short-Term Mortality in Patients with Spontaneous Intracerebral Hemorrhage. Journal of Clinical Medicine, 10(24), 5939. https://doi.org/10.3390/jcm10245939