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Volume 10
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10.3390/jcm10020242
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Article

Mortality and Transfusion Requirements in COVID-19 Hospitalized Italian Patients According to Severity of the Disease

by
Elvira Grandone
1,2,*,
Raffaele Pesavento
3,
Giovanni Tiscia
1,
Antonio De Laurenzo
1,
Davide Ceccato
3,
Maria Teresa Sartori
3,
Lucia Mirabella
4,
Gilda Cinnella
4,
Mario Mastroianno
5,
Lidia Dalfino
6,
Donatella Colaizzo
1,
Roberto Vettor
3,
Angelo Ostuni
7 and
Maurizio Margaglione
8
1
Thrombosis and Haemostasis Unit, Fondazione I.R.C.C.S. “Casa Sollievo della Sofferenza”, 71013 San Giovanni Rotondo, Italy
2
Ob/Gyn Department of the First I.M. Sechenov Moscow State Medical University, 119435 Moscow, Russia
3
Department of Internal Medicine, University of Padua, 35122 Padua, Italy
4
Department of Anesthesia and Intensive care, University of Foggia, 71122 Foggia, Italy
5
Scientific Direction, Fondazione I.R.C.C.S. “Casa Sollievo della Sofferenza”, 71013 San Giovanni Rotondo, Italy
6
Anesthesia and Intensive care Unit, University of Bari, 70121 Bari, Italy
7
Immunohematology and Transfusion Medicine Service, Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari, University of Bari “Aldo Moro”, Struttura Regionale Coordinamento, 70124 Bari, Italy
8
Medical Genetics, University of Foggia, 71122 Foggia, Italy
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2021, 10(2), 242; https://doi.org/10.3390/jcm10020242
Received: 11 December 2020 / Revised: 30 December 2020 / Accepted: 8 January 2021 / Published: 11 January 2021
(This article belongs to the Section Hematology)
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Abstract

There is paucity of data on the transfusion need and its impact on the overall mortality in patients with COVID-19. We explored mortality in hospitalized patients with COVID-19 who required transfusions. Information on clinical variables and in-hospital mortality were obtained from medical records of 422 patients admitted to medical wards or the Intensive Care Unit (ICU). In-hospital mortality occurred in 147 (34.8%) patients, 94 (63.9%) of whom were admitted to the ICU. The median fatalities age was 77 years (IQR 14). Overall, 100 patients (60 males) received transfusion during hospitalization. The overall mortality was significantly and independently associated with age, ICU admission, Chronic Kidney Disease (CKD), and the number of transfused Red Blood Cell (RBC) units. Specifically, CKD was associated with mortality in patients admitted to medical wards, whereas the number of transfused RBC units predicted mortality in those admitted to the ICU. Transfusion strongly interacted with the admission to ICU (OR: 9.9; 95% CI: 2.5–40.0). In patients with COVID-19, age is one of the strongest risk factors in predicting mortality independently of the disease’s severity. CKD confers a higher risk of mortality in patients admitted to medical wards. In those admitted to the ICU, the more RBC units are transfused, the more mortality increases. View Full-Text
Keywords: COVID-19; mortality; transfusion; medical ward; ICU COVID-19; mortality; transfusion; medical ward; ICU
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MDPI and ACS Style

Grandone, E.; Pesavento, R.; Tiscia, G.; De Laurenzo, A.; Ceccato, D.; Sartori, M.T.; Mirabella, L.; Cinnella, G.; Mastroianno, M.; Dalfino, L.; Colaizzo, D.; Vettor, R.; Ostuni, A.; Margaglione, M. Mortality and Transfusion Requirements in COVID-19 Hospitalized Italian Patients According to Severity of the Disease. J. Clin. Med. 2021, 10, 242. https://doi.org/10.3390/jcm10020242

AMA Style

Grandone E, Pesavento R, Tiscia G, De Laurenzo A, Ceccato D, Sartori MT, Mirabella L, Cinnella G, Mastroianno M, Dalfino L, Colaizzo D, Vettor R, Ostuni A, Margaglione M. Mortality and Transfusion Requirements in COVID-19 Hospitalized Italian Patients According to Severity of the Disease. Journal of Clinical Medicine. 2021; 10(2):242. https://doi.org/10.3390/jcm10020242

Chicago/Turabian Style

Grandone, Elvira, Raffaele Pesavento, Giovanni Tiscia, Antonio De Laurenzo, Davide Ceccato, Maria T. Sartori, Lucia Mirabella, Gilda Cinnella, Mario Mastroianno, Lidia Dalfino, Donatella Colaizzo, Roberto Vettor, Angelo Ostuni, and Maurizio Margaglione. 2021. "Mortality and Transfusion Requirements in COVID-19 Hospitalized Italian Patients According to Severity of the Disease" Journal of Clinical Medicine 10, no. 2: 242. https://doi.org/10.3390/jcm10020242

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