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Article

Anti-Obesity Medication Use in Children and Adolescents with Prader–Willi Syndrome: Case Review and Literature Search

1
Department of Pediatrics, Children’s Hospital Los Angeles, Los Angeles, CA 90027, USA
2
Center for Endocrinology, Children’s Hospital Los Angeles, Los Angeles, CA 90027, USA
3
Department of Pediatrics, Keck School of Medicine of University of Southern California, Los Angeles, CA 90033, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Assumpta Caixàs
J. Clin. Med. 2021, 10(19), 4540; https://doi.org/10.3390/jcm10194540
Received: 23 August 2021 / Revised: 24 September 2021 / Accepted: 24 September 2021 / Published: 30 September 2021
(This article belongs to the Collection Endocrinology and Metabolic Diseases: Prader-Willi Syndrome)
(1) Background: children with Prader-Willi syndrome (PWS) have high obesity rates due to hyperphagia and decreased metabolic rates. Although anti-obesity medications (AOMs) are prescribed to this population, there are no consensus guidelines on acceptability, safety, and efficacy. We present literature review and case series on AOMs in youth with PWS. (2) Methods: we performed PubMed review from January 2000 to April 2021 utilizing keywords: “Prader-Willi syndrome” or “PWS” and “medication” including: topiramate, metformin, phentermine, liraglutide, orlistat, oxytocin, semaglutide, naltrexone-bupropion. For our case series, patients were identified through retrospective chart reviews from a multi-disciplinary PWS clinic. Eligibility criteria: age ≤ 18 years, genetically confirmed PWS, AOM use for at least 16 weeks, and recent anthropometric data. (3) Results: a literature search yielded 14 articles (3 topiramate, 1 metformin, 4 liraglutide, 5 oxytocin, 1 naltrexone–bupropion). All studies reported improved hyperphagia with variable BMI effects. Ten adolescents met case series eligibility (mean age 13.2 ± 2.6 years, 40% female; AOMs: 6 metformin, 5 topiramate, 2 semaglutide, 3 liraglutide). After AOM course, 60% had decreased or stable BMI z-score. No significant side effects. (4) Conclusions: results suggest AOMs may be useful for weight management in youth with PWS. Additional studies are required to validate findings and support AOM treatment guidelines. View Full-Text
Keywords: Prader-Willi syndrome; anti-obesity medication; topiramate; metformin; oxytocin; semaglutide; liraglutide; naltrexone-bupropion Prader-Willi syndrome; anti-obesity medication; topiramate; metformin; oxytocin; semaglutide; liraglutide; naltrexone-bupropion
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MDPI and ACS Style

Goldman, V.E.; Naguib, M.N.; Vidmar, A.P. Anti-Obesity Medication Use in Children and Adolescents with Prader–Willi Syndrome: Case Review and Literature Search. J. Clin. Med. 2021, 10, 4540. https://doi.org/10.3390/jcm10194540

AMA Style

Goldman VE, Naguib MN, Vidmar AP. Anti-Obesity Medication Use in Children and Adolescents with Prader–Willi Syndrome: Case Review and Literature Search. Journal of Clinical Medicine. 2021; 10(19):4540. https://doi.org/10.3390/jcm10194540

Chicago/Turabian Style

Goldman, Victoria E., Monica N. Naguib, and Alaina P. Vidmar. 2021. "Anti-Obesity Medication Use in Children and Adolescents with Prader–Willi Syndrome: Case Review and Literature Search" Journal of Clinical Medicine 10, no. 19: 4540. https://doi.org/10.3390/jcm10194540

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