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Article

Do Redox Balance and Inflammatory Events Take Place in Mild Bronchiectasis? A Hint to Clinical Implications

1
Pulmonology Department-Muscle Wasting and Cachexia in Chronic Respiratory Diseases and Lung Cancer Research Group, IMIM-Hospital del Mar, Parc de Salut Mar, Health and Experimental Sciences Department (CEXS), Universitat Pompeu Fabra (UPF), Department of Medicine, Universitat Autònoma de Barcelona, Parc de Recerca Biomèdica de Barcelona (PRBB), 08003 Barcelona, Spain
2
Centro de Investigación en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), 08003 Barcelona, Spain
3
Laboratori de Referència de Catalunya, Clinical Microbiology and Parasitology Department, 08820 Barcelona, Spain
4
Radiology Department, Imatge Mèdica Intercentres-Parc de Salut Mar, Hospital del Mar, 08003 Barcelona, Spain
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Department of Thoracic Surgery, The First Affiliated Hospital of Nanchang University, Nanchang 330000, China
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Scientific and Technical Department, Hospital del Mar-IMIM, 08003 Barcelona, Spain
*
Author to whom correspondence should be addressed.
Academic Editors: Paul King, Lucy Morgan and Emmanuel Andrès
J. Clin. Med. 2021, 10(19), 4534; https://doi.org/10.3390/jcm10194534
Received: 9 July 2021 / Revised: 22 September 2021 / Accepted: 28 September 2021 / Published: 30 September 2021
(This article belongs to the Special Issue Bronchiectasis in Adults: Aetiology and New Therapies)
We hypothesized that in mild bronchiectasis patients, increased systemic inflammation and redox imbalance may take place and correlate with clinical parameters. In plasma samples from patients with very mild bronchiectasis, inflammatory cells and molecules and redox balance parameters were analyzed. In the patients, lung function and exercise capacity, nutritional status, bacterial colonization, and radiological extension were assessed. Correlations between biological and clinical variables were determined. Compared to healthy controls, levels of acute phase reactants, neutrophils, IgG, IgA, myeloperoxidase, protein oxidation, and GSH increased and lung function and exercise capacity were mildly reduced. GSH levels were even greater in ex-smoker and Pseudomona-colonized patients. Furthermore, radiological extension inversely correlated with airway obstruction and, disease severity, and positively correlated with neutrophil numbers in mild bronchiectasis patients with no nutritional abnormalities. In stable patients with mild bronchiectasis, several important inflammatory and oxidative stress events take place in plasma. These findings suggest that the extension of bronchiectasis probably plays a role in the development of redox imbalance and systemic inflammation in patients with mild bronchiectasis. These results have therapeutic implications in the management of bronchiectasis patients. View Full-Text
Keywords: non-CF bronchiectasis patients; prooxidants; antioxidants; acute phase reactants; myeloperoxidase; reduced glutathione; bronchiectasis severity scores non-CF bronchiectasis patients; prooxidants; antioxidants; acute phase reactants; myeloperoxidase; reduced glutathione; bronchiectasis severity scores
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MDPI and ACS Style

Qin, L.; Guitart, M.; Admetlló, M.; Esteban-Cucó, S.; Maiques, J.M.; Xia, Y.; Zha, J.; Carbullanca, S.; Duran, X.; Wang, X.; Barreiro, E. Do Redox Balance and Inflammatory Events Take Place in Mild Bronchiectasis? A Hint to Clinical Implications. J. Clin. Med. 2021, 10, 4534. https://doi.org/10.3390/jcm10194534

AMA Style

Qin L, Guitart M, Admetlló M, Esteban-Cucó S, Maiques JM, Xia Y, Zha J, Carbullanca S, Duran X, Wang X, Barreiro E. Do Redox Balance and Inflammatory Events Take Place in Mild Bronchiectasis? A Hint to Clinical Implications. Journal of Clinical Medicine. 2021; 10(19):4534. https://doi.org/10.3390/jcm10194534

Chicago/Turabian Style

Qin, Liyun, Maria Guitart, Mireia Admetlló, Sandra Esteban-Cucó, José María Maiques, Yingchen Xia, Jianhua Zha, Santiago Carbullanca, Xavier Duran, Xuejie Wang, and Esther Barreiro. 2021. "Do Redox Balance and Inflammatory Events Take Place in Mild Bronchiectasis? A Hint to Clinical Implications" Journal of Clinical Medicine 10, no. 19: 4534. https://doi.org/10.3390/jcm10194534

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