Predictors of Effectiveness of Platelet-Rich Plasma Therapy for Knee Osteoarthritis: A Retrospective Cohort Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patients
2.2. Outcomes
2.3. PRP Preparation
2.4. PRP Injection
2.5. Radiological Analyses
2.6. Statistical Analyses
3. Results
3.1. Patient Characteristics
3.2. Observed Outcomes after PRP According to Patient-Oriented Outcomes and Severity of KOA
3.3. Influence of Malalignment on Effectiveness of PRP Therapy in Severe (KL Grade 4) KOA
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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KL Classification | Total | KL Grade 2 | KL Grade 3 | KL Grade 4 |
---|---|---|---|---|
Number of knees | 517 | 125 | 176 | 216 |
Age (years) | 70.0 (69.1–70.9) | 65.4 (63.4–67.5) | 70.3 (69.1–71.5) | 73.2 (71.9–74.4) |
Sex, male/female (number of patients) | 135/382 | 43/72 | 42/134 | 43/173 |
Height (cm) | 157.6 (157.6–159.2) | 162.6 (160.9–164.3) | 158.5 (157.2–159.8) | 155.8 (154.7–156.9) |
Body weight (kg) | 62.4 (60.5–62.7) | 63.6 (60.9–66.2) | 61.5 (59.7–63.3) | 60.5 (58.9–62.1) |
Body mass index (kg/m2) | 25.0 (24.1–24.8) | 23.8 (23.1–24.5) | 24.4 (23.8–24.9) | 24.9 (24.3–25.4) |
Femorotibial angle (degrees) | 180.6 (180.0–181.0) | 177.5 (176.8–178.1) | 179.4 (178.7–180.0) | 183.2 (182.3–184.1) |
Platelet count (whole blood, ×109/L) | 221.4 (213.9–224.7) | 219.3 (208.8–229.7) | 221.1 (212.1–230.1) | 218.1 (209.0–227.1) |
Platelet count (PRP, ×109/L) | 475.4 (447.7–478.3) | 461.8 (429.4–494.2) | 463.2 (437.1–489.3) | 459.0 (434.7–483.3) |
Predictors | Univariate | Multivariate | ||
---|---|---|---|---|
OR (95% CI) | p-Value | OR (95% CI) | p-Value | |
Age | 0.99 (0.97–1.01) | 0.12 | 0.99 (0.97–1.01) | 0.53 |
Sex | 1.08 (0.72–1.62) | 0.71 | 1.09 (0.68–1.78) | 0.71 |
Body weight | 0.98 (0.97–1.00) | 0.15 | 0.98 (0.97–1.00) | 0.10 |
Kellgren–Lawrence classification | 0.58 (0.45–0.73) | <0.001 | 0.58 (0.45–0.75) | <0.001 |
Platelet count | 1.00 (0.99–1.00) | 0.57 | 1.00 (0.99–1.00) | 0.74 |
Femorotibial Angle, Degrees | Responder Rate (Responders/Number of Patients) |
---|---|
<175 | 12/20 (60.0%, 36.5–83.5) |
175–179 | 18/21 (85.7%, 69.4–102.0) |
180–184 | 39/78 (50.0%, 38.7–61.3) |
185–189 | 32/65 (49.2%, 36.7–61.7) |
≥190 | 9/32 (28.1%, 11.7–44.6) |
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Saita, Y.; Kobayashi, Y.; Nishio, H.; Wakayama, T.; Fukusato, S.; Uchino, S.; Momoi, Y.; Ikeda, H.; Kaneko, K. Predictors of Effectiveness of Platelet-Rich Plasma Therapy for Knee Osteoarthritis: A Retrospective Cohort Study. J. Clin. Med. 2021, 10, 4514. https://doi.org/10.3390/jcm10194514
Saita Y, Kobayashi Y, Nishio H, Wakayama T, Fukusato S, Uchino S, Momoi Y, Ikeda H, Kaneko K. Predictors of Effectiveness of Platelet-Rich Plasma Therapy for Knee Osteoarthritis: A Retrospective Cohort Study. Journal of Clinical Medicine. 2021; 10(19):4514. https://doi.org/10.3390/jcm10194514
Chicago/Turabian StyleSaita, Yoshitomo, Yohei Kobayashi, Hirofumi Nishio, Takanori Wakayama, Shin Fukusato, Sayuri Uchino, Yasumasa Momoi, Hiroshi Ikeda, and Kazuo Kaneko. 2021. "Predictors of Effectiveness of Platelet-Rich Plasma Therapy for Knee Osteoarthritis: A Retrospective Cohort Study" Journal of Clinical Medicine 10, no. 19: 4514. https://doi.org/10.3390/jcm10194514
APA StyleSaita, Y., Kobayashi, Y., Nishio, H., Wakayama, T., Fukusato, S., Uchino, S., Momoi, Y., Ikeda, H., & Kaneko, K. (2021). Predictors of Effectiveness of Platelet-Rich Plasma Therapy for Knee Osteoarthritis: A Retrospective Cohort Study. Journal of Clinical Medicine, 10(19), 4514. https://doi.org/10.3390/jcm10194514