Next Article in Journal
Does Attentional Style Moderate the Relationship between Time Perspective and Social Network Addiction? A Cross-Sectional Study on a Sample of Social Networking Sites Users
Previous Article in Journal
Physical and Mental Health Impacts of the COVID-19 Pandemic among US Adults with Chronic Respiratory Conditions
Article

Prognostic Impact of Acute Cardiovascular Events in COVID-19 Hospitalized Patients—Results from the CORONA Germany Study

1
Department of Cardiology and Internal Intensive Care Medicine, Asklepios Hospital St. Georg, 20099 Hamburg, Germany
2
Asklepios Proresearch, Research Institute, 20099 Hamburg, Germany
3
Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary
4
Asklepios Hospitals GmbH & Co. KGaA, 20099 Hamburg, Germany
5
Department of Hematology, Oncology, Palliative Care Medicine and Rheumatology, Asklepios Hospital Altona, 22763 Hamburg, Germany
6
Department of Anesthesiology and Intensive Care Medicine, Asklepios Hospital St. Georg, 20099 Hamburg, Germany
7
Department of Internal Medicine—Cardiology and Pneumology, Asklepios Hospital Wandsbek, 22043 Hamburg, Germany
8
Department of Internal Medicine I—Gastroenterology, Oncology, Infectious Diseases, Asklepios Hospital Nord-Heidberg, 22417 Hamburg, Germany
9
Department of Oncology and Palliative Care Medicine, Asklepios Hospital Barmbek, 22307 Hamburg, Germany
10
Department of Anesthesiology and Intensive Care Medicine, Asklepios Hospital West, 22559 Hamburg, Germany
11
Department of Pneumology, Asklepios Hospital Harburg, 21075 Hamburg, Germany
*
Author to whom correspondence should be addressed.
Both authors contributed equally to the manuscript.
Academic Editors: Firat Duru and Eue-keun Choi
J. Clin. Med. 2021, 10(17), 3982; https://doi.org/10.3390/jcm10173982
Received: 4 July 2021 / Revised: 16 August 2021 / Accepted: 29 August 2021 / Published: 2 September 2021
(This article belongs to the Section Cardiovascular Medicine)
Background: Acute myocardial injury (AMJ), assessed by elevated levels of cardiac troponin, is associated with fatal outcome in coronavirus disease 2019 (COVID-19). However, the role of acute cardiovascular (CV) events defined by clinical manifestation rather than sole elevations of biomarkers is unclear in hospitalized COVID-19 patients. Objective: The aim of this study was to investigate acute clinically manifest CV events in hospitalized COVID-19 patients. Methods: From 1 March 2020 to 5 January 2021, we conducted a multicenter, prospective, epidemiological cohort study at six hospitals from Hamburg, Germany (a portion of the state-wide 45-center CORONA Germany cohort study) enrolling all hospitalized COVID-19 patients. Primary endpoint was occurrence of a clinically manifest CV-event. Results: In total, 132 CV-events occurred in 92 of 414 (22.2%) patients in the Hamburg-cohort: cardiogenic shock in 10 (2.4%), cardiopulmonary resuscitation in 12 (2.9%), acute coronary syndrome in 11 (2.7%), de-novo arrhythmia in 31 (7.5%), acute heart-failure in 43 (10.3%), myocarditis in 2 (0.5%), pulmonary-embolism in 11 (2.7%), thrombosis in 9 (2.2%) and stroke in 3 (0.7%). In the Hamburg-cohort, mortality was 46% (42/92) for patients with a CV-event and 33% (27/83) for patients with only AMJ without CV-event (OR 1.7, CI: (0.94–3.2), p = 0.077). Mortality was higher in patients with CV-events (Odds ratio(OR): 4.8, 95%-confidence-interval(CI): [2.9–8]). Age (OR 1.1, CI: (0.66–1.86)), atrial fibrillation (AF) on baseline-ECG (OR 3.4, CI: (1.74–6.8)), systolic blood-pressure (OR 0.7, CI: (0.53–0.96)), potassium (OR 1.3, CI: (0.99–1.73)) and C-reactive-protein (1.4, CI (1.04–1.76)) were associated with CV-events. Conclusion: Hospitalized COVID-19 patients with clinical manifestation of acute cardiovascular events show an almost five-fold increased mortality. In this regard, the emergence of arrhythmias is a major determinant. View Full-Text
Keywords: atrial fibrillation; troponin; cardiovascular disease; coronavirus; COVID-19 atrial fibrillation; troponin; cardiovascular disease; coronavirus; COVID-19
Show Figures

Figure 1

MDPI and ACS Style

Gunawardene, M.A.; Gessler, N.; Wohlmuth, P.; Heitmann, K.; Anders, P.; Jaquet, K.; Herborn, C.U.; Arnold, D.; Bein, B.; Bergmann, M.W.; Herrlinger, K.R.; Stang, A.; Schreiber, R.; Wesseler, C.; Willems, S. Prognostic Impact of Acute Cardiovascular Events in COVID-19 Hospitalized Patients—Results from the CORONA Germany Study. J. Clin. Med. 2021, 10, 3982. https://doi.org/10.3390/jcm10173982

AMA Style

Gunawardene MA, Gessler N, Wohlmuth P, Heitmann K, Anders P, Jaquet K, Herborn CU, Arnold D, Bein B, Bergmann MW, Herrlinger KR, Stang A, Schreiber R, Wesseler C, Willems S. Prognostic Impact of Acute Cardiovascular Events in COVID-19 Hospitalized Patients—Results from the CORONA Germany Study. Journal of Clinical Medicine. 2021; 10(17):3982. https://doi.org/10.3390/jcm10173982

Chicago/Turabian Style

Gunawardene, Melanie A., Nele Gessler, Peter Wohlmuth, Kathrin Heitmann, Philipp Anders, Kai Jaquet, Christoph U. Herborn, Dirk Arnold, Berthold Bein, Martin W. Bergmann, Klaus R. Herrlinger, Axel Stang, Ruediger Schreiber, Claas Wesseler, and Stephan Willems. 2021. "Prognostic Impact of Acute Cardiovascular Events in COVID-19 Hospitalized Patients—Results from the CORONA Germany Study" Journal of Clinical Medicine 10, no. 17: 3982. https://doi.org/10.3390/jcm10173982

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop