Next Article in Journal
Analyses of Swallowing Function and Its Related Factors in Community-Dwelling Elderly Patients: A Case-Control Study
Previous Article in Journal
Role of Annual Influenza Vaccination against Lung Cancer in Type 2 Diabetic Patients from a Population-Based Cohort Study
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
JCM
Volume 10
Issue 15
10.3390/jcm10153436
Review Report
jcm-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
Article
Peer-Review Record

Longitudinal Changes in Body Composition of Long-Term Survivors of Pancreatic Head Cancer and Factors Affecting the Changes

J. Clin. Med. 2021, 10(15), 3436; https://doi.org/10.3390/jcm10153436
by Hyun-Ho Kong 1,†, Kyung-Won Kim 2,†, You-Sun Ko 2, Song-Cheol Kim 3, Jae-Hoon Lee 3, Ki-Byung Song 3, Dae-Wook Hwang 3,*,‡ and Won Kim 4,*,‡
Reviewer 1: Anonymous
Reviewer 2: Anonymous
J. Clin. Med. 2021, 10(15), 3436; https://doi.org/10.3390/jcm10153436
Submission received: 8 July 2021 / Revised: 26 July 2021 / Accepted: 30 July 2021 / Published: 2 August 2021
(This article belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Round 1

Reviewer 1 Report

I think your study is very meaningful.

It is interesting that even long survivors did not recover to their preoperative condition.

  • Please describe why did you exclude patients with pancreatic body or tail cancer.
  • "Results" and "Discussion" about Figure 4(a)

The % change of SKM at 18 and 24 months in the recurrence group may reflect a decrease of SKM in patients who have already relapsed.  If you show the % change of SKM at 3, 6, 9, 12 months before the recurrence date, it could be clear the decrease of SKM would be a predictive marker of recurrence.

  • Figure 3 and 4

The % change at 0 months is not “0”. I didn’t understand why?

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

This manuscript by Kong et al describes changes in body composition of long-term survivors of pancreatic head cancer. Only few studies have addressed this topic. This is an interesting and well-designed study; however, we have the following concerns regarding the manuscript.

 

(Major)

The authors limited indications to only pancreatic head cancer cases. The authors should provide an explanation as to why cases of pancreatic body and tail cancer were not included.

 

The authors demonstrated that decreases in body composition failed to recover even 3 years after surgery. There may be several reasons why body composition did not recover in the present study, even in cases without recurrence.

 

One of the factors underlying decreasing body composition may be tumor recurrence. The reviewer suggests that the recurrence may cause decreasing body composition and may confound the results of the present study. Accordingly, this finding may not identify cases of pancreatic cancer with a good prognosis.

 

In figure 3, cases with sarcopenia had decreased subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) compared to skeletal muscle (SKM). Although adipose tissues in cases with sarcopenia had small volumes, the authors should describe potential reasons for the differences observed between sarcopenic and normal cases.

 

 

 

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Back to TopTop