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Article

Effects of Statins on the Incidence and Mortality of Sepsis in Patients with New Cancer Diagnosis

1
Division of Pulmonary and Critical Care Medicine, Penn State Health Milton S Hershey Medical Center, Hershey, PA 17033, USA
2
Department of Public Health Sciences, Penn State Health Milton S Hershey Medical Center, Hershey, PA 17033, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Ekaterini Chatzaki
J. Clin. Med. 2021, 10(15), 3427; https://doi.org/10.3390/jcm10153427
Received: 13 June 2021 / Revised: 29 July 2021 / Accepted: 29 July 2021 / Published: 31 July 2021
(This article belongs to the Section Oncology)
Statins have been associated with improved survival in cancer patients and with decreased incidence and mortality of sepsis in different populations. Our objective was to assess whether newly diagnosed cancer patients on statins had decreased incidence and mortality of sepsis. We analyzed a US database and included 119,379 patients with a new cancer diagnosis (age 55 (50–60) years, 61% female), 19,468 of them (16%) receiving statins. Statins users were older and presented more comorbidities. After adjustment for baseline characteristics, statin use was associated with decreased death hazard (HR 0.897, 95% CI 0.851–0.945, p < 0.0001). The cumulative incidence of sepsis reached 10% at 5 years but statin use was not significantly associated with sepsis hazard (subdistribution hazard ratio 0.990, 95% CI 0.932–1.050, p = 0.73), including in sensitivity analyzes in patients with hematological malignancy or sepsis within 1 year. In patients subsequently hospitalized with sepsis, hospital mortality was 23% and statin use was not associated with mortality (odds ratio 0.952, 95% CI 0.829–1.091, p = 0.48), including in sensitivity analyzes in patients with septic shock and use of statins at the time of sepsis. In summary, treatment with statin at the time of new cancer diagnosis is not associated with a decreased incidence and mortality of sepsis. View Full-Text
Keywords: statin; sepsis; cancer statin; sepsis; cancer
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MDPI and ACS Style

Van de Louw, A.; Cohrs, A.; Leslie, D. Effects of Statins on the Incidence and Mortality of Sepsis in Patients with New Cancer Diagnosis. J. Clin. Med. 2021, 10, 3427. https://doi.org/10.3390/jcm10153427

AMA Style

Van de Louw A, Cohrs A, Leslie D. Effects of Statins on the Incidence and Mortality of Sepsis in Patients with New Cancer Diagnosis. Journal of Clinical Medicine. 2021; 10(15):3427. https://doi.org/10.3390/jcm10153427

Chicago/Turabian Style

Van de Louw, Andry, Austin Cohrs, and Douglas Leslie. 2021. "Effects of Statins on the Incidence and Mortality of Sepsis in Patients with New Cancer Diagnosis" Journal of Clinical Medicine 10, no. 15: 3427. https://doi.org/10.3390/jcm10153427

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