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Review

Modulation of Gut Microbiota for the Prevention and Treatment of COVID-19

by 1 and 1,2,*
1
Medlab Clinical, Research Department, Sydney 2015, Australia
2
Faculty of Medicine and Health, The University of Sydney, Sydney 2006, Australia
*
Author to whom correspondence should be addressed.
Academic Editor: Anastasios Koulaouzidis
J. Clin. Med. 2021, 10(13), 2903; https://doi.org/10.3390/jcm10132903
Received: 16 May 2021 / Revised: 26 June 2021 / Accepted: 28 June 2021 / Published: 29 June 2021
(This article belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
The gut microbiota is well known to exert multiple benefits on human health including protection from disease causing pathobiont microbes. It has been recognized that healthy intestinal microbiota is of great importance in the pathogenesis of COVID-19. Gut dysbiosis caused by various reasons is associated with severe COVID-19. Therefore, the modulation of gut microbiota and supplementation of commensal bacterial metabolites could reduce the severity of COVID-19. Many approaches have been studied to improve gut microbiota in COVID-19 including probiotics, bacterial metabolites, and prebiotics, as well as nutraceuticals and trace elements. So far, 19 clinical trials for testing the efficacy of probiotics and synbiotics in COVID-19 prevention and treatment are ongoing. In this narrative review, we summarize the effects of various approaches on the prevention and treatment of COVID-19 and discuss associated mechanisms. View Full-Text
Keywords: COVID-19; intestinal dysbiosis; butyrate; probiotics; nutraceuticals COVID-19; intestinal dysbiosis; butyrate; probiotics; nutraceuticals
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MDPI and ACS Style

Chen, J.; Vitetta, L. Modulation of Gut Microbiota for the Prevention and Treatment of COVID-19. J. Clin. Med. 2021, 10, 2903. https://doi.org/10.3390/jcm10132903

AMA Style

Chen J, Vitetta L. Modulation of Gut Microbiota for the Prevention and Treatment of COVID-19. Journal of Clinical Medicine. 2021; 10(13):2903. https://doi.org/10.3390/jcm10132903

Chicago/Turabian Style

Chen, Jiezhong, and Luis Vitetta. 2021. "Modulation of Gut Microbiota for the Prevention and Treatment of COVID-19" Journal of Clinical Medicine 10, no. 13: 2903. https://doi.org/10.3390/jcm10132903

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