MDSC in Mice and Men: Mechanisms of Immunosuppression in Cancer

Vanhaver, Christophe; van der Bruggen, Pierre; Bruger, Annika M.

doi:10.3390/jcm10132872

Open AccessReview

MDSC in Mice and Men: Mechanisms of Immunosuppression in Cancer

by

Christophe Vanhaver

^1,*,

Pierre van der Bruggen

^1,2 and

Annika M. Bruger

^1,*

¹

De Duve Institute, Université Catholique de Louvain, Avenue Hippocrate 74, 1200 Brussels, Belgium

²

WELBIO, Avenue Hippocrate 74, 1200 Brussels, Belgium

^*

Authors to whom correspondence should be addressed.

J. Clin. Med. 2021, 10(13), 2872; https://doi.org/10.3390/jcm10132872

Submission received: 11 May 2021 / Revised: 16 June 2021 / Accepted: 18 June 2021 / Published: 28 June 2021

(This article belongs to the Special Issue Myeloid-Derived Suppressor Cells (MDSCs) in Haematology)

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Abstract

Myeloid-derived suppressor cells (MDSCs) expand during pathological conditions in both humans and mice and their presence is linked to poor clinical outcomes for cancer patients. Studying MDSC immunosuppression is restricted by MDSCs’ rarity, short lifespan, heterogeneity, poor viability after freezing and the lack of MDSC-specific markers. In this review, we will compare identification and isolation strategies for human and murine MDSCs. We will also assess what direct and indirect immunosuppressive mechanisms have been attributed to MDSCs. While some immunosuppressive mechanisms are well-documented in mice, e.g., generation of ROS, direct evidence is still lacking in humans. In future, bulk or single-cell genomics could elucidate which phenotypic and functional phenotypes MDSCs adopt in particular microenvironments and help to identify potential targets for therapy.

Keywords: MDSCs; myeloid-derived suppressor cells; T-cells; human; mouse; immunosuppressive assays; cancer biology; immunotherapy

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MDPI and ACS Style

Vanhaver, C.; van der Bruggen, P.; Bruger, A.M. MDSC in Mice and Men: Mechanisms of Immunosuppression in Cancer. J. Clin. Med. 2021, 10, 2872. https://doi.org/10.3390/jcm10132872

AMA Style

Vanhaver C, van der Bruggen P, Bruger AM. MDSC in Mice and Men: Mechanisms of Immunosuppression in Cancer. Journal of Clinical Medicine. 2021; 10(13):2872. https://doi.org/10.3390/jcm10132872

Chicago/Turabian Style

Vanhaver, Christophe, Pierre van der Bruggen, and Annika M. Bruger. 2021. "MDSC in Mice and Men: Mechanisms of Immunosuppression in Cancer" Journal of Clinical Medicine 10, no. 13: 2872. https://doi.org/10.3390/jcm10132872

APA Style

Vanhaver, C., van der Bruggen, P., & Bruger, A. M. (2021). MDSC in Mice and Men: Mechanisms of Immunosuppression in Cancer. Journal of Clinical Medicine, 10(13), 2872. https://doi.org/10.3390/jcm10132872

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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MDSC in Mice and Men: Mechanisms of Immunosuppression in Cancer

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