Next Article in Journal
Does the Addition of Pain Neurophysiology Education to a Therapeutic Exercise Program Improve Physical Function in Women with Fibromyalgia Syndrome? Secondary Analysis of a Randomized Controlled Trial
Previous Article in Journal
Will New Drugs Replace Transplants for Chronic Lymphocytic Leukaemia?
Article

Warning Signals of Post-Exertional Malaise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Retrospective Analysis of 197 Patients

1
Department of Internal Medicine and Clinical Immunology, Angers University Hospital, 49933 Angers, France
2
Department of general medicine, Faculty of Medicine of Angers, 49045 Angers, France
*
Author to whom correspondence should be addressed.
Academic Editor: Nathaniel Watson
J. Clin. Med. 2021, 10(11), 2517; https://doi.org/10.3390/jcm10112517
Received: 24 March 2021 / Revised: 20 May 2021 / Accepted: 4 June 2021 / Published: 7 June 2021
(This article belongs to the Section Clinical Neurology)
Post-exertional malaise (PEM), the key feature of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), is characterized by baseline symptom exacerbation after exposure to a stressor, and some patients can experience new or non-typical symptoms. We hypothesized that new or non-typical symptoms occurring long enough before onset of baseline symptom exacerbation could be warning signals predicting PEM. Adult ME/CFS patients who attended the internal medicine department of Angers University Hospital (France) between October 2011 and December 2019 were included in a retrospective medical records review. Patients who experienced one or more new or non-typical symptoms before baseline symptom exacerbation were compared with the rest of the study population for PEM features, epidemiological characteristics, fatigue features, and comorbidities. New or non-typical symptoms preceded baseline symptom exacerbation in 27/197 (13.7%) patients, and the most frequent ones were mood disorders (37%). When compared to the rest of the study population, only PEM intensity was significantly lower in these patients (p = 0.004), even after adjustment for sex and age at disease onset (p = 0.007). New or non-typical symptoms preceding baseline symptom exacerbation in some ME/CFS patients could be warning signals for PEM. Their identification could help preventing PEM occurrences or reducing their intensity leading to improving disease prognosis. View Full-Text
Keywords: myalgic encephalomyelitis/chronic fatigue syndrome; post-exertional malaise; warning signal; prevention myalgic encephalomyelitis/chronic fatigue syndrome; post-exertional malaise; warning signal; prevention
Show Figures

Figure 1

MDPI and ACS Style

Ghali, A.; Lacout, C.; Ghali, M.; Gury, A.; Delattre, E.; Lavigne, C.; Urbanski, G. Warning Signals of Post-Exertional Malaise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Retrospective Analysis of 197 Patients. J. Clin. Med. 2021, 10, 2517. https://doi.org/10.3390/jcm10112517

AMA Style

Ghali A, Lacout C, Ghali M, Gury A, Delattre E, Lavigne C, Urbanski G. Warning Signals of Post-Exertional Malaise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Retrospective Analysis of 197 Patients. Journal of Clinical Medicine. 2021; 10(11):2517. https://doi.org/10.3390/jcm10112517

Chicago/Turabian Style

Ghali, Alaa, Carole Lacout, Maria Ghali, Aline Gury, Estelle Delattre, Christian Lavigne, and Geoffrey Urbanski. 2021. "Warning Signals of Post-Exertional Malaise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Retrospective Analysis of 197 Patients" Journal of Clinical Medicine 10, no. 11: 2517. https://doi.org/10.3390/jcm10112517

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop