Findings of Brain Magnetic Resonance Imaging in Girls with Central Precocious Puberty Compared with Girls with Chronic or Recurrent Headache
Abstract
:1. Introduction
2. Subjects and Methods
2.1. Patients and Settings
2.2. Measurements
2.3. Brain MRI
- (1)
- Normal;
- (2)
- Positive:
- (a)
- incidental: non-hypothalamic–pituitary (non-H–P) or H–P lesions (mild intracranial alterations not involving the H–P region), which are not considered associated with CPP or headache;
- (b)
- pathological: lesions known to be the cause of or associated with CPP or headache.
2.4. Statistical Analysis
3. Results
3.1. MRI Findings of Girls with CPP
3.2. Comparison of Brain MRI Findings between Girls with CPP and Girls with Headache
3.3. Brain MRI Findings Based on Age at Pubertal Onset in Girls with CPP
3.4. Follow-Up Brain MRI
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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MRI Findings | All Patients (n = 295) |
---|---|
Incidental non-hypothalamic-pituitary legion | |
Neuroglial cyst | 1 (0.3) |
Callosal lipoma | 1 (0.3) |
Tornwaldt’s cyst | 1 (1.3) |
Non-neoplastic cyst | 3 (1.0) |
Nodule of thalamus | 1 (0.3) |
Subependymal gray matter | 1 (0.3) |
Incidental hypothalamic-pituitary legion | |
Rathke cleft cyst | 7 (2.4) |
Arachnoid cyst | 6 (2.0) |
Microadenoma | 5 (1.7) |
Pituitary hypoplasia | 4 (1.4) |
Cyst of pituitary pars intermedia | 3 (1.0) |
Pineal gland cyst | 3 (1.0) |
Pituitary hyperplasia | 2 (0.7) |
Pathological lesion | |
Hypothalamic tuber cinereum hamartoma | 1 (0.3) |
MRI Findings | All Patients (n = 205) |
---|---|
Incidental non-hypothalamic-pituitary legion | |
Neuroepithelial cyst at the temporal region | 1 (0.5) |
Empty sella configuration | 1 (0.5) |
Non-neoplastic cyst | 1 (0.5) |
Partial agenesis of the corpus callosum | 1 (0.5) |
Ventricular dilatation | 2 (1.0) |
Enlarged perivascular space | 1 (0.5) |
Vascular anomalies | 1 (0.5) |
Developmental venous anomaly | 4 (2.0) |
Incidental hypothalamic-pituitary lesion | |
Arachnoid cyst | 7 (3.4) |
Microadenoma | 2 (1.0) |
Rathke cleft cyst | 2 (1.0) |
Pineal gland cyst | 1 (0.5) |
Pathological lesion | |
Moyamoya disease | 1 (0.5) |
MRI Findings | <6 years (n = 33) | 6–6.9 years (n = 148) | 7–7.9 years (n = 114) | p-Value |
---|---|---|---|---|
Normal (n = 256) | 25 (75.8%) | 128 (86.5%) | 103 (90.4%) | NA |
Positive findings (n = 39) | 8 (24.2%) | 20 (13.5%) | 11 (9.6%) | 0.09 |
Incidental findings (n = 38) | 7 (21.2%) | 20 (13.5%) | 11 (9.6%) | 0.21 |
Non-H–P region (n = 7) | 1 (3.0%) | 4 (2.7%) | 3 (2.6%) | >0.99 |
H–P region (n = 31) | 6 (18.2%) | 16 (10.8%) | 8 (7.0%) | 0.16 |
Pathological findings (n = 1) | 1 (3.0%) | 0 | 0 | NA |
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Kim, S.-H.; Ahn, M.B.; Cho, W.K.; Cho, K.S.; Jung, M.H.; Suh, B.-K. Findings of Brain Magnetic Resonance Imaging in Girls with Central Precocious Puberty Compared with Girls with Chronic or Recurrent Headache. J. Clin. Med. 2021, 10, 2206. https://doi.org/10.3390/jcm10102206
Kim S-H, Ahn MB, Cho WK, Cho KS, Jung MH, Suh B-K. Findings of Brain Magnetic Resonance Imaging in Girls with Central Precocious Puberty Compared with Girls with Chronic or Recurrent Headache. Journal of Clinical Medicine. 2021; 10(10):2206. https://doi.org/10.3390/jcm10102206
Chicago/Turabian StyleKim, Shin-Hee, Moon Bae Ahn, Won Kyoung Cho, Kyoung Soon Cho, Min Ho Jung, and Byung-Kyu Suh. 2021. "Findings of Brain Magnetic Resonance Imaging in Girls with Central Precocious Puberty Compared with Girls with Chronic or Recurrent Headache" Journal of Clinical Medicine 10, no. 10: 2206. https://doi.org/10.3390/jcm10102206
APA StyleKim, S.-H., Ahn, M. B., Cho, W. K., Cho, K. S., Jung, M. H., & Suh, B.-K. (2021). Findings of Brain Magnetic Resonance Imaging in Girls with Central Precocious Puberty Compared with Girls with Chronic or Recurrent Headache. Journal of Clinical Medicine, 10(10), 2206. https://doi.org/10.3390/jcm10102206