Effectiveness of 0.66% Povidone-Iodine Eye Drops on Ocular Surface Flora before Cataract Surgery: A Nationwide Microbiological Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Experimental Design
2.2. Participants
2.3. Collection of the Conjunctival Samples
2.4. Microbiological Determinations
2.5. Statistical Analysis
3. Results
3.1. Patients’ Descriptive Characteristics
3.2. Primary Outcome Results
Microbiological Results from Conjunctival Swabs
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Study Group | n = 106 | |
---|---|---|
Median (IQR) age, years | 74 (69–79) | |
Male, n (%) | 42 (39.6) | |
Treated eye, n (%) | Right | 51 (48.1) |
Left | 55 (51.9) |
T0 | T1 | p-Value | |
---|---|---|---|
Median (IQR) total bacteria load, treated eye, CFU/mL | 325 (140–700) | 0 (0–40) | <0.0001 |
Median (IQR) total bacteria load, untreated eye, CFU/mL | 290 (110–930) | 250 (90–700) | 0.29 |
Untreated Eye | Treated Eye | p-Value | |
---|---|---|---|
Median (IQR) total bacteria load at T0, CFU/mL | 290 (110–930) | 325 (140–700) | 0.54 |
Median (IQR) total bacteria load at T1, CFU/mL | 250 (90–700) | 0 (0–40) | <0.0001 |
Median (IQR) total load variation from T0 to T1 | −25 (−250; 170) | −315 (−680; −110) | <0.0001 |
Bacterial positivity (IQR) at T1 | 96 (90.6) | 41 (38.7) | <0.0001 |
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Musumeci, R.; Troiano, P.; Martinelli, M.; Piovella, M.; Carbonara, C.; Rossi, S.; Alessio, G.; Molteni, L.; Molteni, C.G.; Saderi, L.; et al. Effectiveness of 0.66% Povidone-Iodine Eye Drops on Ocular Surface Flora before Cataract Surgery: A Nationwide Microbiological Study. J. Clin. Med. 2021, 10, 2198. https://doi.org/10.3390/jcm10102198
Musumeci R, Troiano P, Martinelli M, Piovella M, Carbonara C, Rossi S, Alessio G, Molteni L, Molteni CG, Saderi L, et al. Effectiveness of 0.66% Povidone-Iodine Eye Drops on Ocular Surface Flora before Cataract Surgery: A Nationwide Microbiological Study. Journal of Clinical Medicine. 2021; 10(10):2198. https://doi.org/10.3390/jcm10102198
Chicago/Turabian StyleMusumeci, Rosario, Pasquale Troiano, Marianna Martinelli, Matteo Piovella, Claudio Carbonara, Scipione Rossi, Giovanni Alessio, Luisa Molteni, Claudio Giuseppe Molteni, Laura Saderi, and et al. 2021. "Effectiveness of 0.66% Povidone-Iodine Eye Drops on Ocular Surface Flora before Cataract Surgery: A Nationwide Microbiological Study" Journal of Clinical Medicine 10, no. 10: 2198. https://doi.org/10.3390/jcm10102198
APA StyleMusumeci, R., Troiano, P., Martinelli, M., Piovella, M., Carbonara, C., Rossi, S., Alessio, G., Molteni, L., Molteni, C. G., Saderi, L., Sotgiu, G., & Cocuzza, C. E. (2021). Effectiveness of 0.66% Povidone-Iodine Eye Drops on Ocular Surface Flora before Cataract Surgery: A Nationwide Microbiological Study. Journal of Clinical Medicine, 10(10), 2198. https://doi.org/10.3390/jcm10102198