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Article

Alterations in Respiratory Function Test Three Months after Hospitalisation for COVID-19 Pneumonia: Value of Determining Nitric Oxide Diffusion

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Service of Pneumology, University Hospital Complex of Vigo, NeumoVigo I+i. Institute of Health Research South Galicia (IISGS), 36213 Vigo, Spain
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Service of Pneumology La Paz-IdiPAZ University Hospital, 28046 Madrid, Spain
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CIBER Respiratory Diseases (CIBERES), 28046 Madrid, Spain
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Department of Medicine, University Autónoma de Madrid, 28046 Madrid, Spain
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Infectious Diseases Unit, Service of Internal Medicine, University Hospital Complex of Vigo, 36213 Vigo, Spain
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Service of Radiodiagnosis, University Hospital Complex of Vigo, 36213 Vigo, Spain
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Department of Biochemistry, Genetics and Immunology, University of Vigo, 36310 Vigo, Spain
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Department of Preventive Medicine and Public Health, University of Santiago de Compostela, 15704 Santiago de Compostela, Spain
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Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 15704 Santiago de Compostela, Spain
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Author to whom correspondence should be addressed.
Academic Editor: Arschang Valipour
J. Clin. Med. 2021, 10(10), 2119; https://doi.org/10.3390/jcm10102119
Received: 22 March 2021 / Revised: 6 May 2021 / Accepted: 11 May 2021 / Published: 14 May 2021
(This article belongs to the Section Pulmonology)
Three to four months after hospitalisation for COVID-19 pneumonia, the most frequently described alteration in respiratory function tests (RFTs) is decreased carbon monoxide transfer capacity (DLCO). Methods: This is a prospective cohort study that included patients hospitalised because of SARS-CoV-2 pneumonia, three months after their discharge. A clinical evaluation, analytical parameters, chest X-ray, six-minute walk test, spirometry and DLCO–DLNO analysis were performed. Demographic variables, comorbidities, and variables related to the severity of the admission were recorded. Results: Two hundred patients completed the study; 59.5% men, age 62 years, 15.5% admitted to the intensive care unit. The most frequent functional alteration, in 27% of patients, was in the DLCO–DLNO combination. This alteration was associated with age, male sex, degree of dyspnoea, poorer perception of health, and limited ability for physical effort. These patients also presented higher levels of D-Dimer and more residual radiological alterations. In 42% of the patients with diffusion alterations, only reduced DLNO was presented, along with lower D-Dimer levels and less capillary volume involvement. The severity of the process was associated with the reduction in DLCO–DLNO. Conclusions: The most sensitive RFT for the detection of the sequelae of COVID-19 pneumonia was the combined measurement of DLCO–DLNO and this factor was related to patient health status and their capacity for physical exertion. In 40% of these cases, there was only a reduction in DLNO, a finding that may indicate less pulmonary vascular involvement. View Full-Text
Keywords: COVID-19; pneumonia; sequelae; respiratory function tests; diffusion capacity; DLCO; DLNO COVID-19; pneumonia; sequelae; respiratory function tests; diffusion capacity; DLCO; DLNO
MDPI and ACS Style

Núñez-Fernández, M.; Ramos-Hernández, C.; García-Río, F.; Torres-Durán, M.; Nodar-Germiñas, A.; Tilve-Gómez, A.; Rodríguez-Fernández, P.; Valverde-Pérez, D.; Ruano-Raviña, A.; Fernández-Villar, A. Alterations in Respiratory Function Test Three Months after Hospitalisation for COVID-19 Pneumonia: Value of Determining Nitric Oxide Diffusion. J. Clin. Med. 2021, 10, 2119. https://doi.org/10.3390/jcm10102119

AMA Style

Núñez-Fernández M, Ramos-Hernández C, García-Río F, Torres-Durán M, Nodar-Germiñas A, Tilve-Gómez A, Rodríguez-Fernández P, Valverde-Pérez D, Ruano-Raviña A, Fernández-Villar A. Alterations in Respiratory Function Test Three Months after Hospitalisation for COVID-19 Pneumonia: Value of Determining Nitric Oxide Diffusion. Journal of Clinical Medicine. 2021; 10(10):2119. https://doi.org/10.3390/jcm10102119

Chicago/Turabian Style

Núñez-Fernández, Marta, Cristina Ramos-Hernández, Francisco García-Río, María Torres-Durán, Andrés Nodar-Germiñas, Amara Tilve-Gómez, Paula Rodríguez-Fernández, Diana Valverde-Pérez, Alberto Ruano-Raviña, and Alberto Fernández-Villar. 2021. "Alterations in Respiratory Function Test Three Months after Hospitalisation for COVID-19 Pneumonia: Value of Determining Nitric Oxide Diffusion" Journal of Clinical Medicine 10, no. 10: 2119. https://doi.org/10.3390/jcm10102119

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