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The Role of Myeloid-Derived Suppressor Cells (MDSCs) in Graft-versus-Host Disease (GVHD)

Hematology Department—BMT Unit, G Papanicolaou Hospital, 57010 Thessaloniki, Greece
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Academic Editors: Helen A. Papadaki and Håkon Reikvam
J. Clin. Med. 2021, 10(10), 2050; https://doi.org/10.3390/jcm10102050
Received: 8 March 2021 / Revised: 2 May 2021 / Accepted: 6 May 2021 / Published: 11 May 2021
(This article belongs to the Special Issue Myeloid-Derived Suppressor Cells (MDSCs) in Haematology)
Background: Myeloid-derived suppressor cells (MDSCs) are implicated in the complex interplay involving graft-versus-leukemia (GVL) effects and graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (allo-HCT) in hematologic malignancies. Methods: A review of literature through PubMed was undertaken to summarize the published evidence on the pathophysiology and clinical implications of MDSCs in allo-HCT. Literature sources published in English since 1978 were searched, using the terms Natural Suppressor (NS) cells, MDSCs, GVHD, and allo-HCT. Results: In vivo studies demonstrated that MDSCs derived from mobilization protocols could strongly suppress allo-responses mediated by T cells and enhance T-Reg activity, thus inhibiting GVHD toxicity. However, the influence of MDSCs on the GVL effect is not fully defined. Conclusions: The induction or maintenance of MDSC suppressive function would be advantageous in suppressing inflammation associated with GVHD. Pathways involved in MDSC metabolism and the inflammasome signaling are a promising field of study to elucidate the function of MDSCs in the pathogenesis of GVHD and translate these findings to a clinical setting. View Full-Text
Keywords: NS cells; MDSCs; allo-HCT; GVHD; GVL NS cells; MDSCs; allo-HCT; GVHD; GVL
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MDPI and ACS Style

Demosthenous, C.; Sakellari, I.; Douka, V.; Papayanni, P.G.; Anagnostopoulos, A.; Gavriilaki, E. The Role of Myeloid-Derived Suppressor Cells (MDSCs) in Graft-versus-Host Disease (GVHD). J. Clin. Med. 2021, 10, 2050. https://doi.org/10.3390/jcm10102050

AMA Style

Demosthenous C, Sakellari I, Douka V, Papayanni PG, Anagnostopoulos A, Gavriilaki E. The Role of Myeloid-Derived Suppressor Cells (MDSCs) in Graft-versus-Host Disease (GVHD). Journal of Clinical Medicine. 2021; 10(10):2050. https://doi.org/10.3390/jcm10102050

Chicago/Turabian Style

Demosthenous, Christos, Ioanna Sakellari, Vassiliki Douka, Penelope G. Papayanni, Achilles Anagnostopoulos, and Eleni Gavriilaki. 2021. "The Role of Myeloid-Derived Suppressor Cells (MDSCs) in Graft-versus-Host Disease (GVHD)" Journal of Clinical Medicine 10, no. 10: 2050. https://doi.org/10.3390/jcm10102050

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