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Extracellular miRNAs for the Management of Barrett’s Esophagus and Esophageal Adenocarcinoma: A Systematic Review

1
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
2
Department of Molecular and Cellular Medicine, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2021, 10(1), 117; https://doi.org/10.3390/jcm10010117
Received: 3 October 2020 / Revised: 26 December 2020 / Accepted: 28 December 2020 / Published: 31 December 2020
(This article belongs to the Special Issue New Advances in Gastroesophageal Reflux Disease)
Esophageal adenocarcinoma (EAC), the major histologic type of esophageal cancer (EC) in Western countries, is a disease with a poor prognosis, primarily due to usual diagnosis at an advanced stage. The prevalence of EAC has increased in recent years, both in Western countries and in Asia. Barrett’s esophagus (BE) is a precursor lesion of EAC. Therefore, early detection and proper management of BE and EAC is important to improve prognosis. Here, we systematically summarize current knowledge about the potential utility of extracellular microRNAs (miRNAs), which are thought to be non-invasive biomarkers for many diseases, for these purposes. A search of the PubMed and Embase databases identified 22 papers about extracellular miRNAs that have potential utility for management of EAC. Among them, 19 were EAC-related and ten were BE-related; some of these dealt with both conditions. The articles included studies reporting diagnosis, prognosis, and treatment responses. Multiple papers report dysregulation of miR-194-5p in BE and miR-21-5p, -25-3p, and -93-5p in EAC. Although it will take time to utilize these miRNAs in clinical practice, they are likely to be useful non-invasive markers in the future. View Full-Text
Keywords: esophageal cancer; GERD; miRNA; biomarker esophageal cancer; GERD; miRNA; biomarker
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MDPI and ACS Style

Inokuchi, K.; Ochiya, T.; Matsuzaki, J. Extracellular miRNAs for the Management of Barrett’s Esophagus and Esophageal Adenocarcinoma: A Systematic Review. J. Clin. Med. 2021, 10, 117. https://doi.org/10.3390/jcm10010117

AMA Style

Inokuchi K, Ochiya T, Matsuzaki J. Extracellular miRNAs for the Management of Barrett’s Esophagus and Esophageal Adenocarcinoma: A Systematic Review. Journal of Clinical Medicine. 2021; 10(1):117. https://doi.org/10.3390/jcm10010117

Chicago/Turabian Style

Inokuchi, Kazumi; Ochiya, Takahiro; Matsuzaki, Juntaro. 2021. "Extracellular miRNAs for the Management of Barrett’s Esophagus and Esophageal Adenocarcinoma: A Systematic Review" J. Clin. Med. 10, no. 1: 117. https://doi.org/10.3390/jcm10010117

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