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Article

A Composite Membrane System with Gold Nanoparticles, Hydroxyapatite, and Fullerenol for Dual Interaction for Biomedical Purposes

1
Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Trojdena 4 St., 02-109 Warsaw, Poland
2
Institute of Paleobiology, Polish Academy of Sciences, Twarda 51/55 St., 02-109 Warsaw, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Enrico Drioli
Membranes 2021, 11(8), 565; https://doi.org/10.3390/membranes11080565
Received: 25 June 2021 / Revised: 19 July 2021 / Accepted: 23 July 2021 / Published: 27 July 2021
(This article belongs to the Special Issue Membrane Systems for Biomedical Engineering)
Background: Wound dressing plays a vital role in post-operative aftercare. There is the necessity to develop dressings for application on the border of soft and hard tissue. This study aimed to develop multifunctional polyelectrolyte layers enhanced by hydroxyapatite nanoparticles, gold nanoparticles (AuNPs), and/or fullerenol nanocomposites to achieve a wound dressing that could be applied on the bone-skin interface. Methods: Constructed shells were examined using TEM, STEM, and EDX techniques. The human osteoblasts or fibroblasts were immobilized within the shells. The systems morphology was assessed using SEM. The functioning of cells was determined by flow cytomery. Moreover, the internalization of AuNPs was assessed. Results: Involvement of fullerenol and/or hydroxyapatite nanoparticles influenced the immobilized cell systems morphology. Membranes with fullerenol and hydroxyapatite nanoparticles were observed to block the internalization of AuNPs by immobilized hFOB cells. Conclusions: The designed bilayer membranes incorporating fullerenol, and bacteriostatic elements, prevented the internalization of AuNPs by hFOB cells and ensured the proper counts and morphology of eukaryotic cells. The developed material can be recommended for dressings at the bone-skin interface. View Full-Text
Keywords: polyelectrolyte multilayered membranes; osteoblasts; fibroblasts polyelectrolyte multilayered membranes; osteoblasts; fibroblasts
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MDPI and ACS Style

Grzeczkowicz, A.; Drabik, M.; Lipko, A.; Bącal, P.; Kwiatkowska, A.; Kazimierczak, B.; Granicka, L.H. A Composite Membrane System with Gold Nanoparticles, Hydroxyapatite, and Fullerenol for Dual Interaction for Biomedical Purposes. Membranes 2021, 11, 565. https://doi.org/10.3390/membranes11080565

AMA Style

Grzeczkowicz A, Drabik M, Lipko A, Bącal P, Kwiatkowska A, Kazimierczak B, Granicka LH. A Composite Membrane System with Gold Nanoparticles, Hydroxyapatite, and Fullerenol for Dual Interaction for Biomedical Purposes. Membranes. 2021; 11(8):565. https://doi.org/10.3390/membranes11080565

Chicago/Turabian Style

Grzeczkowicz, Anna, Monika Drabik, Agata Lipko, Paweł Bącal, Angelika Kwiatkowska, Beata Kazimierczak, and Ludomira H. Granicka 2021. "A Composite Membrane System with Gold Nanoparticles, Hydroxyapatite, and Fullerenol for Dual Interaction for Biomedical Purposes" Membranes 11, no. 8: 565. https://doi.org/10.3390/membranes11080565

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