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Polyunsaturated Fatty Acids Mediated Regulation of Membrane Biochemistry and Tumor Cell Membrane Integrity

1
Department of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur 495009, Chhattisgarh, India
2
Department of Pharmacology & Toxicology, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia
3
Department of Pharmaceutical Sciences, Assam University, Silchar 788011, Assam, India
*
Authors to whom correspondence should be addressed.
Academic Editors: Tanima Bose and Terry Hébert
Membranes 2021, 11(7), 479; https://doi.org/10.3390/membranes11070479
Received: 14 May 2021 / Revised: 5 June 2021 / Accepted: 24 June 2021 / Published: 28 June 2021
(This article belongs to the Special Issue Membrane Channel of Cells)
Particular dramatic macromolecule proteins are responsible for various cellular events in our body system. Lipids have recently recognized a lot more attention of scientists for understanding the relationship between lipid and cellular function and human health However, a biological membrane is formed with a lipid bilayer, which is called a P–L–P design. Our body system is balanced through various communicative signaling pathways derived from biological membrane proteins and lipids. In the case of any fatal disease such as cancer, the biological membrane compositions are altered. To repair the biological membrane composition and prevent cancer, dietary fatty acids, such as omega-3 polyunsaturated fatty acids, are essential in human health but are not directly synthesized in our body system. In this review, we will discuss the alteration of the biological membrane composition in breast cancer. We will highlight the role of dietary fatty acids in altering cellular composition in the P–L–P bilayer. We will also address the importance of omega-3 polyunsaturated fatty acids to regulate the membrane fluidity of cancer cells. View Full-Text
Keywords: biological membrane; breast cancer; polyunsaturated fatty acid; membrane remodeling; P–L–P membrane channel; ALA and GLA biological membrane; breast cancer; polyunsaturated fatty acid; membrane remodeling; P–L–P membrane channel; ALA and GLA
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MDPI and ACS Style

Mukerjee, S.; Saeedan, A.S.; Ansari, M.N.; Singh, M. Polyunsaturated Fatty Acids Mediated Regulation of Membrane Biochemistry and Tumor Cell Membrane Integrity. Membranes 2021, 11, 479. https://doi.org/10.3390/membranes11070479

AMA Style

Mukerjee S, Saeedan AS, Ansari MN, Singh M. Polyunsaturated Fatty Acids Mediated Regulation of Membrane Biochemistry and Tumor Cell Membrane Integrity. Membranes. 2021; 11(7):479. https://doi.org/10.3390/membranes11070479

Chicago/Turabian Style

Mukerjee, Souvik, Abdulaziz S. Saeedan, Mohd. N. Ansari, and Manjari Singh. 2021. "Polyunsaturated Fatty Acids Mediated Regulation of Membrane Biochemistry and Tumor Cell Membrane Integrity" Membranes 11, no. 7: 479. https://doi.org/10.3390/membranes11070479

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