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Volume 8
Issue 3
10.3390/vaccines8030496
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Article

A Zika Vaccine Generated Using the Chimeric Insect-Specific Binjari Virus Platform Protects against Fetal Brain Infection in Pregnant Mice

by
Jessamine E. Hazlewood
1,
Daniel J. Rawle
1,
Bing Tang
1,
Kexin Yan
1,
Laura J. Vet
2,
Eri Nakayama
3,
Jody Hobson-Peters
2,4,
Roy A. Hall
2,4,* and
Andreas Suhrbier
1,4,*
1
Inflammation Biology Group, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia
2
School of Chemistry and Molecular Biosciences, University of Queensland, St. Lucia, QLD 4072, Australia
3
Department of Virology I, National Institute of Infectious Diseases, Tokyo 162-0052, Japan
4
Australian Infectious Diseases Research Centre, Brisbane, QLD 4006, Australia
*
Authors to whom correspondence should be addressed.
Vaccines 2020, 8(3), 496; https://doi.org/10.3390/vaccines8030496
Submission received: 12 August 2020 / Revised: 31 August 2020 / Accepted: 31 August 2020 / Published: 2 September 2020
(This article belongs to the Special Issue Virus-Like Particle & Nanoparticle Vaccines against Viral Infections)
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Abstract

Zika virus (ZIKV) is the etiological agent of congenital Zika syndrome (CZS), a spectrum of birth defects that can lead to life-long disabilities. A range of vaccines are in development with the target population including pregnant women and women of child-bearing age. Using a recently described chimeric flavivirus vaccine technology based on the novel insect-specific Binjari virus (BinJV), we generated a ZIKV vaccine (BinJ/ZIKA-prME) and illustrate herein its ability to protect against fetal brain infection. Female IFNAR−/− mice were vaccinated once with unadjuvanted BinJ/ZIKA-prME, were mated, and at embryonic day 12.5 were challenged with ZIKVPRVABC59. No infectious ZIKV was detected in maternal blood, placenta, or fetal heads in BinJ/ZIKA-prME-vaccinated mice. A similar result was obtained when the more sensitive qRT PCR methodology was used to measure the viral RNA. BinJ/ZIKA-prME vaccination also did not result in antibody-dependent enhancement of dengue virus infection or disease. BinJ/ZIKA-prME thus emerges as a potential vaccine candidate for the prevention of CSZ.
Keywords: vaccine; Binjari; Zika; dengue; mouse model vaccine; Binjari; Zika; dengue; mouse model

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MDPI and ACS Style

Hazlewood, J.E.; Rawle, D.J.; Tang, B.; Yan, K.; Vet, L.J.; Nakayama, E.; Hobson-Peters, J.; Hall, R.A.; Suhrbier, A. A Zika Vaccine Generated Using the Chimeric Insect-Specific Binjari Virus Platform Protects against Fetal Brain Infection in Pregnant Mice. Vaccines 2020, 8, 496. https://doi.org/10.3390/vaccines8030496

AMA Style

Hazlewood JE, Rawle DJ, Tang B, Yan K, Vet LJ, Nakayama E, Hobson-Peters J, Hall RA, Suhrbier A. A Zika Vaccine Generated Using the Chimeric Insect-Specific Binjari Virus Platform Protects against Fetal Brain Infection in Pregnant Mice. Vaccines. 2020; 8(3):496. https://doi.org/10.3390/vaccines8030496

Chicago/Turabian Style

Hazlewood, Jessamine E., Daniel J. Rawle, Bing Tang, Kexin Yan, Laura J. Vet, Eri Nakayama, Jody Hobson-Peters, Roy A. Hall, and Andreas Suhrbier. 2020. "A Zika Vaccine Generated Using the Chimeric Insect-Specific Binjari Virus Platform Protects against Fetal Brain Infection in Pregnant Mice" Vaccines 8, no. 3: 496. https://doi.org/10.3390/vaccines8030496

APA Style

Hazlewood, J. E., Rawle, D. J., Tang, B., Yan, K., Vet, L. J., Nakayama, E., Hobson-Peters, J., Hall, R. A., & Suhrbier, A. (2020). A Zika Vaccine Generated Using the Chimeric Insect-Specific Binjari Virus Platform Protects against Fetal Brain Infection in Pregnant Mice. Vaccines, 8(3), 496. https://doi.org/10.3390/vaccines8030496

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