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Review

Factors Affecting the Antibody Immunogenicity of Vaccines against SARS-CoV-2: A Focused Review

1
State Key Laboratory of Respiratory Disease, National Clinical Research Center of Respiratory Disease, Department of Allergy and Clinical Immunology, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510623, China
2
Department of Clinical Medicine, The Third Clinical School of Guangzhou Medical University, Guangzhou 510182, China
3
Faculty of Health Sciences, University of Macau, Taipa, Macau 999078, China
*
Author to whom correspondence should be addressed.
These authors contributed equally.
Academic Editor: Siddappa N. Byrareddy
Vaccines 2021, 9(8), 869; https://doi.org/10.3390/vaccines9080869
Received: 18 June 2021 / Revised: 11 July 2021 / Accepted: 2 August 2021 / Published: 5 August 2021
(This article belongs to the Special Issue Vaccination Strategies for COVID-19)
Vaccines are a crucial part of the global anti-pandemic effort against COVID-19. The effects of vaccines, as well as their common influencing factors, are the most important issues that we should focus on at this time. To this end, we review statistics on immunogenicity after vaccination, using neutralizing antibodies as the main reference index. Age, infection history, and virus variants are compared, and vaccination program recommendations are made accordingly. Suggestions are made to address concerns raised by the vaccines’ shortened development cycle, as well as the emergence of immunity escape of viral variants. Finally, a brief description and future prospects are provided based on the principle of the ADE effect and previous experience with similar viruses. View Full-Text
Keywords: COVID-19; vaccines; neutralizing antibody; variants; ADE COVID-19; vaccines; neutralizing antibody; variants; ADE
MDPI and ACS Style

Cheng, Z.J.; Xue, M.; Zheng, P.; Lyu, J.; Zhan, Z.; Hu, H.; Zhang, Y.; Zhang, X.D.; Sun, B. Factors Affecting the Antibody Immunogenicity of Vaccines against SARS-CoV-2: A Focused Review. Vaccines 2021, 9, 869. https://doi.org/10.3390/vaccines9080869

AMA Style

Cheng ZJ, Xue M, Zheng P, Lyu J, Zhan Z, Hu H, Zhang Y, Zhang XD, Sun B. Factors Affecting the Antibody Immunogenicity of Vaccines against SARS-CoV-2: A Focused Review. Vaccines. 2021; 9(8):869. https://doi.org/10.3390/vaccines9080869

Chicago/Turabian Style

Cheng, Zhangkai J., Mingshan Xue, Peiyan Zheng, Jiali Lyu, Zhiqing Zhan, Haisheng Hu, Yong Zhang, Xiaohua D. Zhang, and Baoqing Sun. 2021. "Factors Affecting the Antibody Immunogenicity of Vaccines against SARS-CoV-2: A Focused Review" Vaccines 9, no. 8: 869. https://doi.org/10.3390/vaccines9080869

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