An Outbreak of COVID-19 among mRNA-Vaccinated Nursing Home Residents

Round 1

Reviewer 1 Report

Thank you for allowing me to review the case report entitled, “An outbreak of COVID-19 among mRNA-vaccinated nursing home residents” by Faggiano et al.   I believe it presents important information about responsiveness to COVID vaccination in a particularly vulnerable population.

Minor Changes:

1. Line 12: “20 of whom fully vaccinated” should read “20 of whom were fully vaccinated”
2. Line 26: “prioritize” should read prioritized”
3. Line 39:”is matter of discussion” should read “is a matter of discussion”
4. Lines 39-47: This seems like it might fit better into a discussion than as a part of the introduction.
5. Line 65: “once identified the first case” should read “once the first case was identified”
6. Line 70: when you say on the same day, do you mean March 19?  I would clarify
7. Line 70: “performed to all staff” should read “performed on all staff”
8. Line 70: “confirmed the SARS-CoV-2” should read “confirmed SARS-coV-2”
9. Line 74: you say that 4 of the positive guests were vaccinated.  How long had it been between vaccination and infection?
10. Line 121: Would consider an alternative work for “resumed”. Maybe “presented”
11. Lines 173-177: Would consider reformatting to be clearer.
12. Line 179: consider say “vaccination of nursing home guests”. Rather than “vaccination of nursing homes.”
13. Line 188: would consider removing the work “too”

Author Response

Dear reviewer,

thank you for your comments and suggestions.

Response to Reviewer 1 Comments

Point 1: Line 12: “20 of whom fully vaccinated” should read “20 of whom were fully vaccinated”

Thank you, I have made the correction

 Point 2: Line 26: “prioritize” should read prioritized”

Thank you, I have made the correction

Point 3: Line 39:”is matter of discussion” should read “is a matter of discussion”

Thank you, I have made the correction

Point 4: Lines 39-47: This seems like it might fit better into a discussion than as a part of the introduction.

I moved the text in the discussion section

Point 5: Line 65: “once identified the first case” should read “once the first case was identified”

Thank you, I have made the correction

 Point 6: Line 70: when you say on the same day, do you mean March 19?  I would clarify

Yes, it’s March 19. I specified it in the text

Point 7: Line 70: “performed to all staff” should read “performed on all staff”

Thank you, I have made the correction

Point 8: Line 70: “confirmed the SARS-CoV-2” should read “confirmed SARS-coV-2”

Thank you, I have made the correction

Point 9: Line 74: you say that 4 of the positive guests were vaccinated.  How long had it been between vaccination and infection?

It is specified in lines 64-66. All the vaccinated guests received the vaccination in January and early February

Point 10: Line 121: Would consider an alternative work for “resumed”. Maybe “presented”

Thank you, I have made the correction

Point 11: Lines 173-177: Would consider reformatting to be clearer.

Moving before these lines the text cited on point 4 I think this section is clearer.

Point 12: Line 179: consider say “vaccination of nursing home guests”. Rather than “vaccination of nursing homes.”

Thank you, I have made the correction

 Point 13: Line 188: would consider removing the work “too”
Thank you, I have made the correction

Best regards

Maicol Rossi

Reviewer 2 Report

I have few minor comments to revise before accepting this case report for publication.

Line 35: Please explain the abbreviation RCTs

Line 73: What was the procedure used for identification of English variant? Was it from whole genome sequencing? Or RT-PCR specific for English variant?

Line 87: Is it 3 positive healthcare workers or 4? Table 1 total indicates 3.

Line 181: Reproduction rate? I suggest to use replication rate

Line 182: What is the wild-type strain?

Reference section needs formatting.

Author Response

Dear reviewer,

thank you for your comments and suggestions.

Response to Reviewer 2 Comments

Point 1: Line 35: Please explain the abbreviation RCTs

I inserted the explanation of the abbreviation

Point 2: Line 73: What was the procedure used for identification of English variant? Was it from whole genome sequencing? Or RT-PCR specific for English variant?

It was from whole genome sequencing. I modified the text

Point 3: Line 87: Is it 3 positive healthcare workers or 4? Table 1 total indicates 3.

I’m sorry for the mistake in table 1. The healthcare workers were 4.

Point 4: Line 181: Reproduction rate? I suggest to use replication rate

Thank you, I have made the correction

Point 5: Line 182: What is the wild-type strain?

I clarified in the text

Point 6: Reference section needs formatting.

I checked and formatted were needed

Best regards

Maicol Rossi