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Review

COVID-19 and Pregnancy: Vertical Transmission and Inflammation Impact on Newborns

1
Université de Paris, NeuroDiderot, Inserm, 75019 Paris, France
2
INSERM U1184, CEA, IDMIT Department, Immunology of Viral, Auto-Immune, Hematological and Bacterial Diseases (IMVA-HB), Université Paris-Saclay, 92265 Fontenay-aux-Roses, France
*
Author to whom correspondence should be addressed.
Academic Editor: Ralph A. Tripp
Vaccines 2021, 9(4), 391; https://doi.org/10.3390/vaccines9040391
Received: 28 February 2021 / Revised: 8 April 2021 / Accepted: 10 April 2021 / Published: 15 April 2021
(This article belongs to the Special Issue Immune Ontogeny and Vaccination in Early Life)
The COVID-19 pandemic is ongoing and we are still compiling new findings to decipher and understand SARS-CoV-2 infection during pregnancy. No reports encompass any conclusive confirmation of vertical transmission. Nevertheless, cases of fetal distress and multiple organ failure have been reported, as well as rare cases of fetal demise. While clinicians and scientists continue to seek proof of vertical transmission, they miss the greater point, namely the cause of preterm delivery. In this review, we suggest that the cause might not be due to the viral infection but the fetal exposure to maternal inflammation or cytokine storm that translates into a complication of COVID-19. This statement is extrapolated from previous experience with infections and inflammation which were reported to be fatal by increasing the risk of preterm delivery and causing abnormal neonatal brain development and resulting in neurological disorders like atypical behavioral phenotype or autistic syndrome. Given the potentially fatal consequences on neonate health, we highlight the urgent need for an animal model to study vertical transmission. The preclinical model will allow us to make the link between SARS-COV-2 infection, inflammation and long-term follow-up of child brain development. View Full-Text
Keywords: COVID-19; fetus; newborn; transmission; immunity; inflammation; preterm delivery; central nervous system; neurodevelopmental disorders COVID-19; fetus; newborn; transmission; immunity; inflammation; preterm delivery; central nervous system; neurodevelopmental disorders
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MDPI and ACS Style

Joma, M.; Fovet, C.-M.; Seddiki, N.; Gressens, P.; Laforge, M. COVID-19 and Pregnancy: Vertical Transmission and Inflammation Impact on Newborns. Vaccines 2021, 9, 391. https://doi.org/10.3390/vaccines9040391

AMA Style

Joma M, Fovet C-M, Seddiki N, Gressens P, Laforge M. COVID-19 and Pregnancy: Vertical Transmission and Inflammation Impact on Newborns. Vaccines. 2021; 9(4):391. https://doi.org/10.3390/vaccines9040391

Chicago/Turabian Style

Joma, Mohamed, Claire-Maelle Fovet, Nabila Seddiki, Pierre Gressens, and Mireille Laforge. 2021. "COVID-19 and Pregnancy: Vertical Transmission and Inflammation Impact on Newborns" Vaccines 9, no. 4: 391. https://doi.org/10.3390/vaccines9040391

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