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Perspective

Dissolvable Microneedle Patches to Enable Increased Access to Vaccines against SARS-CoV-2 and Future Pandemic Outbreaks

1
Hope Clinic of the Emory Vaccine Center, Division of Infectious Diseases, Department of Medicine, School of Medicine, Emory University, 500 Irvin Court, Suite 200, Decatur, Atlanta, GA 30030, USA
2
School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Vita Golubovskaya, Emmanuel Datan and Vasso Apostolopoulos
Vaccines 2021, 9(4), 320; https://doi.org/10.3390/vaccines9040320
Received: 26 February 2021 / Revised: 25 March 2021 / Accepted: 30 March 2021 / Published: 1 April 2021
(This article belongs to the Special Issue Advances in Vaccine Development and Immunotherapies)
Vaccines are an essential component of pandemic preparedness but can be limited due to challenges in production and logistical implementation. While vaccine candidates were rapidly developed against severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), immunization campaigns remain an obstacle to achieving herd immunity. Dissolvable microneedle patches are advantageous for many possible reasons: improved immunogenicity; dose-sparing effects; expected low manufacturing cost; elimination of sharps; reduction of vaccine wastage; no need for reconstitution; simplified supply chain, with reduction of cold chain supply through increased thermostability; ease of use, reducing the need for healthcare providers; and greater acceptability compared to traditional hypodermic injections. When applied to coronavirus disease 2019 (COVID-19) and future pandemic outbreaks, microneedle patches have great potential to improve vaccination globally and save many lives. View Full-Text
Keywords: dissolvable microneedle patch; drug delivery; skin vaccination; vaccine delivery; equity dissolvable microneedle patch; drug delivery; skin vaccination; vaccine delivery; equity
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MDPI and ACS Style

O’Shea, J.; Prausnitz, M.R.; Rouphael, N. Dissolvable Microneedle Patches to Enable Increased Access to Vaccines against SARS-CoV-2 and Future Pandemic Outbreaks. Vaccines 2021, 9, 320. https://doi.org/10.3390/vaccines9040320

AMA Style

O’Shea J, Prausnitz MR, Rouphael N. Dissolvable Microneedle Patches to Enable Increased Access to Vaccines against SARS-CoV-2 and Future Pandemic Outbreaks. Vaccines. 2021; 9(4):320. https://doi.org/10.3390/vaccines9040320

Chicago/Turabian Style

O’Shea, Jesse; Prausnitz, Mark R.; Rouphael, Nadine. 2021. "Dissolvable Microneedle Patches to Enable Increased Access to Vaccines against SARS-CoV-2 and Future Pandemic Outbreaks" Vaccines 9, no. 4: 320. https://doi.org/10.3390/vaccines9040320

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